PMID- 34165135
OWN - NLM
STAT- MEDLINE
DCOM- 20220119
LR  - 20220119
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 12
IP  - 15
DP  - 2021 Aug 2
TI  - Molecular mechanisms from insulin-mimetic effect of vitamin D: treatment 
      alternative in Type 2 diabetes mellitus.
PG  - 6682-6690
LID - 10.1039/d0fo03230a [doi]
AB  - Diabetes mellitus is a complex and multifactorial disease with a global 
      prevalence that exceeds 425 million people. Type 2 diabetes mellitus (T2DM) is 
      characterized by a state of insulin resistance, which leads to metabolic 
      alterations that aggravate the state of health of people. Vitamin D deficiency 
      appears to play an important role in the triggering mechanisms of insulin 
      resistance. In this review, an analysis is made of the biochemical mechanisms 
      associated with the insulin-mimetic effect of vitamin D, its supplementation 
      being a possible nutritional strategy for the T2DM treatment. The current 
      scientific evidence is extensive regarding the dose of vitamin D used for an 
      insulin-mimetic effect. However, clinical trials and systematic reviews show 
      statistical differences on glucose, insulin, and glycated hemoglobin levels of 
      patients with T2DM, associated with activation mechanisms of transcription 
      factors related to genes of the glucide metabolism and the insulin receptor, and 
      the regulation of intracellular Ca2+ insulin concentrations. Likewise, an 
      indirect mechanism associated with antioxidant and anti-inflammatory effects has 
      been shown that also leads to sensitivity to the insulin receptor. The use of a 
      specific dose of vitamin D could be an effective alternative in the T2DM 
      treatment, which would reduce the risk of complications derived from 
      hyperglycemia.
FAU - Torres Dominguez, Edwin A
AU  - Torres Dominguez EA
AD  - Universidad Latino, Periferico Norte, Merida, Yucatan, Mexico. 
      eemartinez.leo@gmail.com.
FAU - Meza Penafiel, Abigail
AU  - Meza Penafiel A
FAU - Gomez Pedraza, Arturo
AU  - Gomez Pedraza A
FAU - Martinez Leo, Edwin E
AU  - Martinez Leo EE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Blood Glucose/physiology
MH  - *Diabetes Mellitus, Type 2
MH  - Humans
MH  - *Insulin
MH  - Insulin Resistance/*physiology
MH  - *Vitamin D
MH  - Vitamin D Deficiency
EDAT- 2021/06/25 06:00
MHDA- 2022/01/20 06:00
CRDT- 2021/06/24 09:34
PHST- 2021/06/25 06:00 [pubmed]
PHST- 2022/01/20 06:00 [medline]
PHST- 2021/06/24 09:34 [entrez]
AID - 10.1039/d0fo03230a [doi]
PST - ppublish
SO  - Food Funct. 2021 Aug 2;12(15):6682-6690. doi: 10.1039/d0fo03230a.