PMID- 34165902
OWN - NLM
STAT- MEDLINE
DCOM- 20211220
LR  - 20231107
IS  - 2198-3844 (Electronic)
IS  - 2198-3844 (Linking)
VI  - 8
IP  - 12
DP  - 2021 Jun
TI  - Smart Cargo Delivery System based on Mesoporous Nanoparticles for Bone Disease 
      Diagnosis and Treatment.
PG  - e2004586
LID - 10.1002/advs.202004586 [doi]
LID - 2004586
AB  - Bone diseases constitute a major issue for modern societies as a consequence of 
      progressive aging. Advantages such as open mesoporous channel, high specific 
      surface area, ease of surface modification, and multifunctional integration are 
      the driving forces for the application of mesoporous nanoparticles (MNs) in bone 
      disease diagnosis and treatment. To achieve better therapeutic effects, it is 
      necessary to understand the properties of MNs and cargo delivery mechanisms, 
      which are the foundation and key in the design of MNs. The main types and 
      characteristics of MNs for bone regeneration, such as mesoporous silica (mSiO(2) 
      ), mesoporous hydroxyapatite (mHAP), mesoporous calcium phosphates (mCaPs) are 
      introduced. Additionally, the relationship between the cargo release mechanisms 
      and bone regeneration of MNs-based nanocarriers is elucidated in detail. 
      Particularly, MNs-based smart cargo transport strategies such as sustained cargo 
      release, stimuli-responsive (e.g., pH, photo, ultrasound, and multi-stimuli) 
      controllable delivery, and specific bone-targeted therapy for bone disease 
      diagnosis and treatment are analyzed and discussed in depth. Lastly, the 
      conclusions and outlook about the design and development of MNs-based cargo 
      delivery systems in diagnosis and treatment for bone tissue engineering are 
      provided to inspire new ideas and attract researchers' attention from 
      multidisciplinary areas spanning chemistry, materials science, and biomedicine.
CI  - (c) 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.
FAU - Pan, Panpan
AU  - Pan P
AD  - Department of Chemistry, Department of Gastroenterology, Zhongshan Hospital of 
      Fudan University, State Key Laboratory of Molecular Engineering of Polymers, 
      Fudan University, Shanghai, 200433, China.
FAU - Yue, Qin
AU  - Yue Q
AD  - Institute of Fundamental and Frontier Sciences, University of Electronic Science 
      and Technology of China, Chengdu, 610051, China.
FAU - Li, Juan
AU  - Li J
AD  - Department of Chemistry, Department of Gastroenterology, Zhongshan Hospital of 
      Fudan University, State Key Laboratory of Molecular Engineering of Polymers, 
      Fudan University, Shanghai, 200433, China.
FAU - Gao, Meiqi
AU  - Gao M
AD  - Department of Chemistry, Department of Gastroenterology, Zhongshan Hospital of 
      Fudan University, State Key Laboratory of Molecular Engineering of Polymers, 
      Fudan University, Shanghai, 200433, China.
FAU - Yang, Xuanyu
AU  - Yang X
AD  - Department of Chemistry, Department of Gastroenterology, Zhongshan Hospital of 
      Fudan University, State Key Laboratory of Molecular Engineering of Polymers, 
      Fudan University, Shanghai, 200433, China.
FAU - Ren, Yuan
AU  - Ren Y
AD  - Department of Chemistry, Department of Gastroenterology, Zhongshan Hospital of 
      Fudan University, State Key Laboratory of Molecular Engineering of Polymers, 
      Fudan University, Shanghai, 200433, China.
FAU - Cheng, Xiaowei
AU  - Cheng X
AD  - Department of Chemistry, Department of Gastroenterology, Zhongshan Hospital of 
      Fudan University, State Key Laboratory of Molecular Engineering of Polymers, 
      Fudan University, Shanghai, 200433, China.
FAU - Cui, Penglei
AU  - Cui P
AD  - Department of Orthopedic Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao 
      Tong University School of Medicine, Shanghai, 200092, China.
FAU - Deng, Yonghui
AU  - Deng Y
AUID- ORCID: 0000-0002-0657-9397
AD  - Department of Chemistry, Department of Gastroenterology, Zhongshan Hospital of 
      Fudan University, State Key Laboratory of Molecular Engineering of Polymers, 
      Fudan University, Shanghai, 200433, China.
AD  - State Key Lab of Transducer Technology, Shanghai Institute of Microsystem and 
      Information Technology, Chinese Academy of Sciences, Shanghai, 200050, China.
LA  - eng
GR  - 21875044/NSF/
GR  - 52073064/NSF/
GR  - 22005058/NSF/
GR  - 22005057/NSF/
GR  - 2020YFB2008600/National Key R&D Program of China/
GR  - 19XD1420300/Program of Shanghai Academic Research Leader/
GR  - 2020M670973/China Postdoctoral Science Foundation/
GR  - BX20200085/China Postdoctoral Science Foundation/
GR  - SKT1904/state key laboratory of Transducer Technology of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210316
PL  - Germany
TA  - Adv Sci (Weinh)
JT  - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
JID - 101664569
RN  - 0 (Drug Carriers)
SB  - IM
MH  - Bone Diseases/*diagnosis/*therapy
MH  - Bone Regeneration
MH  - Drug Carriers/chemistry
MH  - Drug Delivery Systems/*methods
MH  - Humans
MH  - Nanoparticles/chemistry
MH  - Tissue Engineering/*methods
PMC - PMC8224433
OTO - NOTNLM
OT  - bone targeting
OT  - diagnosis and treatment
OT  - mesoporous nanoparticle
OT  - smart cargo delivery
OT  - stimuli responsiveness
COIS- The authors declare no conflict of interest.
EDAT- 2021/06/25 06:00
MHDA- 2021/12/21 06:00
PMCR- 2021/03/16
CRDT- 2021/06/24 12:41
PHST- 2021/01/11 00:00 [revised]
PHST- 2020/11/27 00:00 [received]
PHST- 2021/06/24 12:41 [entrez]
PHST- 2021/06/25 06:00 [pubmed]
PHST- 2021/12/21 06:00 [medline]
PHST- 2021/03/16 00:00 [pmc-release]
AID - ADVS2491 [pii]
AID - 10.1002/advs.202004586 [doi]
PST - ppublish
SO  - Adv Sci (Weinh). 2021 Jun;8(12):e2004586. doi: 10.1002/advs.202004586. Epub 2021 
      Mar 16.