PMID- 34167924
OWN - NLM
STAT- MEDLINE
DCOM- 20220419
LR  - 20220809
IS  - 2254-8874 (Electronic)
IS  - 2254-8874 (Linking)
VI  - 222
IP  - 4
DP  - 2022 Apr
TI  - Meta-analysis evaluating the risk of respiratory tract infections and acute 
      respiratory distress syndrome with glucagon-like peptide-1 receptor agonists in 
      cardiovascular outcome trials: Useful implications for the COVID-19 pandemic.
PG  - 229-232
LID - S2254-8874(21)00101-6 [pii]
LID - 10.1016/j.rceng.2021.04.002 [doi]
AB  - Patients with type 2 diabetes mellitus (T2DM) are at increased risk for severe 
      coronavirus disease 2019 (COVID-19) and related mortality. Glucagon-like 
      peptide-1 receptor agonists (GLP-1-RAs) have significant cardiovascular and renal 
      benefits for patients with T2DM and related comorbidities. Their 
      anti-inflammatory properties could be beneficial in these patients. This work 
      provides less-biased estimates regarding the risk for respiratory tract 
      infections and acute respiratory distress syndrome by performing the first 
      significant meta-analysis of cardiovascular outcome trials in the literature. 
      Notably, GLP-1-RAs do not seem to increase the risk for respiratory tract 
      infection, pneumonia, or acute respiratory distress syndrome in patients with 
      T2DM and cardiovascular comorbidities.
CI  - Copyright (c) 2021 Elsevier Espana, S.L.U. and Sociedad Espanola de Medicina 
      Interna (SEMI). All rights reserved.
FAU - Patoulias, D
AU  - Patoulias D
AD  - Second Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, General Hospital "Hippokration", Thessaloniki, Greece. Electronic 
      address: dipatoulias@gmail.com.
FAU - Boulmpou, A
AU  - Boulmpou A
AD  - Third Department of Cardiology, Aristotle University of Thessaloniki, General 
      Hospital "Hippokration", Thessaloniki, Greece.
FAU - Imprialos, K
AU  - Imprialos K
AD  - Second Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, General Hospital "Hippokration", Thessaloniki, Greece.
FAU - Stavropoulos, K
AU  - Stavropoulos K
AD  - Second Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, General Hospital "Hippokration", Thessaloniki, Greece.
FAU - Papadopoulos, C
AU  - Papadopoulos C
AD  - Third Department of Cardiology, Aristotle University of Thessaloniki, General 
      Hospital "Hippokration", Thessaloniki, Greece.
FAU - Doumas, M
AU  - Doumas M
AD  - Second Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, General Hospital "Hippokration", Thessaloniki, Greece; Veterans 
      Affairs Medical Center, George Washington University, Washington, District of 
      Columbia, Columbia, United States.
LA  - eng
PT  - Case Reports
PT  - Meta-Analysis
DEP - 20210605
PL  - Spain
TA  - Rev Clin Esp (Barc)
JT  - Revista clinica espanola
JID - 101632437
RN  - 0 (Glucagon-Like Peptide-1 Receptor)
RN  - 0 (Hypoglycemic Agents)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - *COVID-19
MH  - *Cardiovascular Diseases/epidemiology/etiology
MH  - *Diabetes Mellitus, Type 2/chemically induced/complications/drug therapy
MH  - Glucagon-Like Peptide 1
MH  - Glucagon-Like Peptide-1 Receptor/agonists
MH  - Humans
MH  - Hypoglycemic Agents/adverse effects
MH  - Pandemics
MH  - *Respiratory Distress Syndrome/drug therapy
PMC - PMC8179096
OTO - NOTNLM
OT  - Agonistas del receptor del peptido similar al glucagon tipo 1
OT  - COVID-19
OT  - Diabetes mellitus tipo 2
OT  - Glucagon-like peptide-1 receptor agonists
OT  - Infeccion respiratoria
OT  - Neumonia
OT  - Pneumonia
OT  - Respiratory infection
OT  - Type 2 diabetes mellitus
EDAT- 2021/06/26 06:00
MHDA- 2022/04/20 06:00
PMCR- 2021/06/05
CRDT- 2021/06/25 05:50
PHST- 2021/03/22 00:00 [received]
PHST- 2021/04/13 00:00 [accepted]
PHST- 2021/06/26 06:00 [pubmed]
PHST- 2022/04/20 06:00 [medline]
PHST- 2021/06/25 05:50 [entrez]
PHST- 2021/06/05 00:00 [pmc-release]
AID - S2254-8874(21)00101-6 [pii]
AID - 10.1016/j.rceng.2021.04.002 [doi]
PST - ppublish
SO  - Rev Clin Esp (Barc). 2022 Apr;222(4):229-232. doi: 10.1016/j.rceng.2021.04.002. 
      Epub 2021 Jun 5.