PMID- 34168244
OWN - NLM
STAT- MEDLINE
DCOM- 20211105
LR  - 20240226
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jun 24
TI  - Genetic background influences the effect of thirdhand smoke exposure on anxiety 
      and memory in Collaborative Cross mice.
PG  - 13285
LID - 10.1038/s41598-021-92702-1 [doi]
LID - 13285
AB  - Growing evidence indicates that thirdhand smoke (THS) exposure induces many 
      adverse health effects. However, it is unclear how THS exposure affects behavior 
      and how host genetic background modulates phenotypic changes. Here we used the 
      Collaborative Cross (CC) mouse population-based model to assess behavioral 
      alterations immediately after THS exposure from 4 to 9 weeks of age. We first 
      measured anxiety-like behavior in six strains using light/dark box combined with 
      a custom multivariate mouse tracking system. We developed an anxiety risk scoring 
      system based on anxiety-related traits and then evaluated the THS impact on them. 
      THS exposure significantly decreased anxiety risk in CC019 (P = 0.002) and CC051 
      (P = 0.009), but increased anxiety risk in CC036 (P < 0.001), while the other 
      three strains did not show significant changes in anxiety-related traits. Such 
      differences were driven by female mice for the six measures of anxiety-like 
      behavior. Memory potential was measured in the same cohort of mice using the 
      passive avoidance assay. Both THS-exposed male and female CC019 mice displayed 
      significant memory loss compared to controls while no significant changes were 
      found in the other five strains. This study provides strong evidence that THS 
      exposure leads to strain-dependent changes in anxiety-like behavior and memory, 
      suggesting that host genetic variations play a critical role in individual 
      susceptibility to THS-induced effects.
FAU - He, Li
AU  - He L
AD  - Department of Internal Hematology, Zhongnan Hospital of Wuhan University, Wuhan, 
      430071, Hubei, China.
FAU - Wang, Pin
AU  - Wang P
AD  - Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital 
      of Nanjing University Medical School, Nanjing, 210008, Jiangsu, China.
FAU - Schick, Suzyann F
AU  - Schick SF
AD  - Division of Occupational and Environmental Medicine, Department of Medicine, 
      University of California, San Francisco, CA, 94143, USA.
FAU - Huang, Abel
AU  - Huang A
AD  - Division of Occupational and Environmental Medicine, Department of Medicine, 
      University of California, San Francisco, CA, 94143, USA.
FAU - Jacob, Peyton 3rd
AU  - Jacob P 3rd
AD  - Division of Cardiology, Department of Medicine, Clinical Pharmacology Program, 
      University of California, San Francisco, CA, 94143, USA.
FAU - Yang, Xu
AU  - Yang X
AD  - School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, 
      China.
FAU - Xia, Yankai
AU  - Xia Y
AD  - School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, 
      China.
FAU - Snijders, Antoine M
AU  - Snijders AM
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA, 94720, USA.
FAU - Mao, Jian-Hua
AU  - Mao JH
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA, 94720, USA.
FAU - Chang, Hang
AU  - Chang H
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA, 94720, USA. HChang@lbl.gov.
FAU - Hang, Bo
AU  - Hang B
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA, 94720, USA. Bo_Hang@lbl.gov.
LA  - eng
GR  - P30 DA012393/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210624
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Animals
MH  - Anxiety/*etiology/genetics
MH  - Collaborative Cross Mice/genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Memory/*drug effects
MH  - Risk Factors
MH  - Tobacco Smoke Pollution/*adverse effects
MH  - Mice
PMC - PMC8225773
COIS- The authors declare no competing interests.
EDAT- 2021/06/26 06:00
MHDA- 2021/11/06 06:00
PMCR- 2021/06/24
CRDT- 2021/06/25 06:36
PHST- 2021/02/18 00:00 [received]
PHST- 2021/06/08 00:00 [accepted]
PHST- 2021/06/25 06:36 [entrez]
PHST- 2021/06/26 06:00 [pubmed]
PHST- 2021/11/06 06:00 [medline]
PHST- 2021/06/24 00:00 [pmc-release]
AID - 10.1038/s41598-021-92702-1 [pii]
AID - 92702 [pii]
AID - 10.1038/s41598-021-92702-1 [doi]
PST - epublish
SO  - Sci Rep. 2021 Jun 24;11(1):13285. doi: 10.1038/s41598-021-92702-1.