PMID- 34169425
OWN - NLM
STAT- MEDLINE
DCOM- 20211222
LR  - 20211222
IS  - 2523-899X (Electronic)
IS  - 2523-899X (Linking)
VI  - 41
IP  - 3
DP  - 2021 Jun
TI  - Ligustrazine Attenuates Hyperhomocysteinemia-induced Alzheimer-like Pathologies 
      in Rats.
PG  - 548-554
LID - 10.1007/s11596-021-2379-1 [doi]
AB  - Ligustrazine, an alkaloid extracted from the traditional Chinese herbal medicine 
      Ligusticum Chuanxiong Hort, has been clinically applied to treat the 
      cerebrovascular diseases. Hyperhomocysteinemia (Hhcy) is an independent risk 
      factor for Alzheimer's disease (AD). Memory deficits can be caused by Hhcy via 
      pathologies of AD-like tau and amyloid-beta (Abeta) in the hippocampus. Here, we 
      investigated whether homocysteine (Hcy) can induce AD-like pathologies and the 
      effects of ligustrazine on these pathologies. The Hcy rat model was constructed 
      by 14-day Hcy injection via vena caudalis, and rats were treated with daily 
      intragastric administration of ligustrazine at the same time. We found that the 
      pathologies of tau and Abeta were induced by Hcy in the hippocampus, while the 
      Hcy-induced tau hyperphosphorylation and Abeta accumulation could be markedly 
      attenuated by simultaneous ligustrazine treatment. Our data demonstrate that 
      ligustrazine may be used as a promising neuroprotective agent to treat the 
      Hcy-induced AD-like pathologies.
CI  - (c) 2021. Huazhong University of Science and Technology.
FAU - Zhang, Qing
AU  - Zhang Q
AD  - Laboratory of Neurological Diseases, the Affiliated Changzhou No. 2 People's 
      Hospital of Nanjing Medical University, Changzhou, 213003, China.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Pediatrics, the Affiliated Changzhou No. 2 People's Hospital of 
      Nanjing Medical University, Changzhou, 213003, China.
FAU - Zhu, Liang
AU  - Zhu L
AD  - Department of Anesthesiology, the Affiliated Changzhou No. 2 People's Hospital of 
      Nanjing Medical University, Changzhou, 213003, China.
FAU - Jiang, Shi-Jie
AU  - Jiang SJ
AD  - Department of Orthopedics, the Affiliated Changzhou No. 2 People's Hospital of 
      Nanjing Medical University, Changzhou, 213003, China.
FAU - Liu, Juan
AU  - Liu J
AD  - Department of Endocrinology, the Affiliated Changzhou No. 2 People's Hospital of 
      Nanjing Medical University, Changzhou, 213003, China.
FAU - Wang, Lin-Xiao
AU  - Wang LX
AD  - Laboratory of Neurological Diseases, the Affiliated Changzhou No. 2 People's 
      Hospital of Nanjing Medical University, Changzhou, 213003, China. suwlx@163.com.
FAU - Qin, Xi-Hu
AU  - Qin XH
AD  - Department of General Surgery, the Affiliated Changzhou No. 2 People's Hospital 
      of Nanjing Medical University, Changzhou, 213000, China. zcfmlm@njmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210625
PL  - China
TA  - Curr Med Sci
JT  - Current medical science
JID - 101729993
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Pyrazines)
RN  - V80F4IA5XG (tetramethylpyrazine)
SB  - IM
MH  - Alzheimer Disease/*drug therapy/etiology/genetics/pathology
MH  - Amyloid beta-Peptides
MH  - Animals
MH  - Brain/drug effects/pathology
MH  - Disease Models, Animal
MH  - Hippocampus/drug effects/metabolism
MH  - Humans
MH  - Hyperhomocysteinemia/complications/*drug therapy/genetics/pathology
MH  - Memory Disorders/*drug therapy/etiology/genetics/pathology
MH  - Neurons/drug effects/pathology
MH  - Neuroprotective Agents/pharmacology
MH  - Phosphorylation/drug effects
MH  - Pyrazines/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - cognitive impairment
OT  - hyperhomocysteinemia
OT  - ligustrazine
OT  - phosphorylated tau
EDAT- 2021/06/26 06:00
MHDA- 2021/12/24 06:00
CRDT- 2021/06/25 07:02
PHST- 2020/10/31 00:00 [received]
PHST- 2020/11/26 00:00 [accepted]
PHST- 2021/06/26 06:00 [pubmed]
PHST- 2021/12/24 06:00 [medline]
PHST- 2021/06/25 07:02 [entrez]
AID - 10.1007/s11596-021-2379-1 [pii]
AID - 10.1007/s11596-021-2379-1 [doi]
PST - ppublish
SO  - Curr Med Sci. 2021 Jun;41(3):548-554. doi: 10.1007/s11596-021-2379-1. Epub 2021 
      Jun 25.