PMID- 34169461
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20220531
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
VI  - 74
IP  - 2
DP  - 2021 Nov
TI  - Association of diabetes-related variants in ADCY5 and CDKAL1 with neonatal 
      insulin, C-peptide, and birth weight.
PG  - 318-331
LID - 10.1007/s12020-021-02799-7 [doi]
AB  - BACKGROUND AND PURPOSE: Neonates at the highest and lowest percentiles of birth 
      weight present an increased risk of developing metabolic diseases in adult life. 
      While environmental events in utero may play an important role in this 
      association, some genetic variants are associated both with birth weight and type 
      2 diabetes mellitus (T2DM), suggesting a genetic link between intrauterine growth 
      and metabolism in adult life. Variants rs11708067 in ADCY5 and rs7754840 in 
      CDKAL1 are associated with low birth weight, risk of T2DM, and lower insulin 
      secretion in adults. We aimed to investigate whether, besides birth weight, these 
      polymorphisms were related to insulin secretion at birth. METHODS: A cohort of 
      218 healthy term newborns from uncomplicated pregnancies were evaluated for 
      anthropometric and biochemical variables. Cord blood insulin and C-peptide were 
      analyzed by ELISA. Genotyping of rs11708067 in ADCY5 and rs7754840 in CDKAL1 was 
      performed. RESULTS: Newborns carrying the A allele of ADCY5 rs11708067 had lower 
      cord blood insulin and C-peptide, even after adjusting by maternal glycemia, 
      HbA1c, and pregestational BMI. Lower birth weight was found for AA-AG genotypes 
      compared to GG, but no differences were seen in adjusted birth weight or z-score. 
      Variant rs7754840 in CDKAL1 was not associated with birth weight, neonatal 
      insulin, or C-peptide for any genotype or genetic model. CONCLUSIONS: The variant 
      rs11708067 in ADCY5 is associated with lower neonatal insulin and C-peptide 
      concentrations. Our results suggest that the genetic influence on insulin 
      secretion may be evident from birth, even in healthy newborns, independently of 
      maternal glycemia and BMI.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Aguilera-Venegas, Ivette-Guadalupe
AU  - Aguilera-Venegas IG
AD  - Medical Sciences Department, Health Sciences Division, University of Guanajuato, 
      Guanajuato, Mexico.
FAU - Mora-Pena, Julia-Del-Socorro
AU  - Mora-Pena JD
AD  - Medical Sciences Department, Health Sciences Division, University of Guanajuato, 
      Guanajuato, Mexico.
FAU - Velazquez-Villafana, Marion
AU  - Velazquez-Villafana M
AD  - Medical Sciences Department, Health Sciences Division, University of Guanajuato, 
      Guanajuato, Mexico.
FAU - Gonzalez-Dominguez, Martha-Isabel
AU  - Gonzalez-Dominguez MI
AD  - Universidad de la Cienega del Estado de Michoacan de Ocampo, Trayectoria de 
      Ingenieria en Nanotecnologia, Sahuayo, Michoacan, Mexico.
FAU - Barbosa-Sabanero, Gloria
AU  - Barbosa-Sabanero G
AD  - Medical Sciences Department, Health Sciences Division, University of Guanajuato, 
      Guanajuato, Mexico.
FAU - Gomez-Zapata, Hector-Manuel
AU  - Gomez-Zapata HM
AD  - UMAE No. 48 IMSS, Leon, Guanajuato, Mexico.
FAU - Lazo-de-la-Vega-Monroy, Maria-Luisa
AU  - Lazo-de-la-Vega-Monroy ML
AUID- ORCID: 0000-0001-7646-2605
AD  - Medical Sciences Department, Health Sciences Division, University of Guanajuato, 
      Guanajuato, Mexico. mlazo@ugto.mx.
LA  - eng
PT  - Journal Article
DEP - 20210624
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (C-Peptide)
RN  - 0 (Insulin)
RN  - EC 2.1.1.- (tRNA Methyltransferases)
RN  - EC 2.8.4.5 (CDKAL1 protein, human)
RN  - EC 4.6.1.1 (Adenylyl Cyclases)
RN  - EC 4.6.1.1 (adenylyl cyclase type V)
SB  - IM
MH  - Adenylyl Cyclases/*genetics
MH  - Adult
MH  - Birth Weight
MH  - C-Peptide
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - *Insulin
MH  - Pregnancy
MH  - *tRNA Methyltransferases/genetics
OTO - NOTNLM
OT  - ADCY5
OT  - Birth weight
OT  - CDKAL1
OT  - Neonatal insulin
EDAT- 2021/06/26 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/06/25 07:02
PHST- 2020/12/02 00:00 [received]
PHST- 2021/06/09 00:00 [accepted]
PHST- 2021/06/26 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/06/25 07:02 [entrez]
AID - 10.1007/s12020-021-02799-7 [pii]
AID - 10.1007/s12020-021-02799-7 [doi]
PST - ppublish
SO  - Endocrine. 2021 Nov;74(2):318-331. doi: 10.1007/s12020-021-02799-7. Epub 2021 Jun 
      24.