PMID- 34169498
OWN - NLM
STAT- MEDLINE
DCOM- 20211227
LR  - 20211227
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 53
IP  - 7
DP  - 2021 Jul
TI  - Resistin is Associated with Inflammation and Renal Function, but not with Insulin 
      Resistance in Type 2 Diabetes.
PG  - 478-484
LID - 10.1055/a-1492-3077 [doi]
AB  - The aim of the study was to investigate the association of adipokines (resistin, 
      leptin and adiponectin) with obesity, insulin resistance (IR) and inflammation in 
      type 2 diabetes mellitus (T2DM). A total of 284 patients with T2DM were included. 
      Concentrations of resistin, leptin, adiponectin, and inflammatory markers [high 
      sensitivity C-reactive protein (hsCRP), tumor necrosis factor alpha (TNF-alpha), and 
      interleukin 6 (IL-6)] were measured and homeostatic model assessment for IR 
      (HOMA-IR) index was calculated. Resistin correlated negatively with estimated 
      glomerular filtration rate (eGFR) and positively with hsCRP, TNF-alpha, IL-6, and 
      white blood cell count (WBC). Leptin correlated positively with HOMA-IR, whereas 
      adiponectin correlated negatively. Leptin also correlated positively with body 
      mass index (BMI), waist circumference, IL-6, WBC and negatively with eGFR. 
      Adiponectin correlated negatively with waist circumference, WBC, and eGFR. 
      Multivariate logistic regression indicated lower eGFR and higher WBC and IL-6 as 
      independent predictive factors of resistin concentration above the upper quartile 
      (CAQ3), whereas female sex and higher BMI and HOMA-IR of leptin CAQ3, and lower 
      HOMA-IR and older age of adiponectin CAQ3. In conclusion, in contrast to leptin 
      and adiponectin, in T2DM patients, resistin is not associated with BMI and IR, 
      but with inflammation and worse kidney function.
CI  - Thieme. All rights reserved.
FAU - Rzepa, Lukasz
AU  - Rzepa L
AD  - 1st Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, 
      Poland.
FAU - Peller, Michal
AU  - Peller M
AD  - 1st Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, 
      Poland.
FAU - Eyileten, Ceren
AU  - Eyileten C
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Warsaw, Poland.
FAU - Rosiak, Marek
AU  - Rosiak M
AD  - Department of Cardiology and Hypertension, Central Clinical Hospital, Warsaw, 
      Poland.
FAU - Kondracka, Agnieszka
AU  - Kondracka A
AD  - Department of Internal Diseases and Endocrinology, Medical University of Warsaw, 
      Warsaw, Poland.
FAU - Mirowska-Guzel, Dagmara
AU  - Mirowska-Guzel D
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Warsaw, Poland.
FAU - Opolski, Grzegorz
AU  - Opolski G
AD  - 1st Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, 
      Poland.
FAU - Filipiak, Krzysztof J
AU  - Filipiak KJ
AD  - 1st Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, 
      Poland.
FAU - Postula, Marek
AU  - Postula M
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Warsaw, Poland.
FAU - Kaplon-Cieslicka, Agnieszka
AU  - Kaplon-Cieslicka A
AD  - 1st Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, 
      Poland.
LA  - eng
PT  - Journal Article
DEP - 20210624
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (LEP protein, human)
RN  - 0 (Leptin)
RN  - 0 (RETN protein, human)
RN  - 0 (Resistin)
SB  - IM
MH  - Adipokines/blood
MH  - Adiponectin/genetics/metabolism
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/*blood
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - *Glomerular Filtration Rate
MH  - Humans
MH  - Inflammation/etiology/metabolism/*pathology
MH  - *Insulin Resistance
MH  - Kidney Function Tests
MH  - Leptin/genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Resistin/genetics/*metabolism
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/06/26 06:00
MHDA- 2021/12/28 06:00
CRDT- 2021/06/25 07:03
PHST- 2021/06/26 06:00 [pubmed]
PHST- 2021/12/28 06:00 [medline]
PHST- 2021/06/25 07:03 [entrez]
AID - 10.1055/a-1492-3077 [doi]
PST - ppublish
SO  - Horm Metab Res. 2021 Jul;53(7):478-484. doi: 10.1055/a-1492-3077. Epub 2021 Jun 
      24.