PMID- 34170301
OWN - NLM
STAT- MEDLINE
DCOM- 20211210
LR  - 20211214
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 106
IP  - 11
DP  - 2021 Oct 21
TI  - Effects of Proton Pump Inhibitors on Glycemic Control and Incident Diabetes: A 
      Systematic Review and Meta-analysis.
PG  - 3354-3366
LID - 10.1210/clinem/dgab353 [doi]
AB  - CONTEXT: Whether proton pump inhibitors (PPI) can improve glycemic control among 
      individuals with diabetes or decrease the risk of incident diabetes in the 
      general population is unclear. OBJECTIVE: To evaluate the impact of PPI therapy 
      on glycemic control among individuals with diabetes and the risk of diabetes 
      among those without diabetes. RESULTS: PubMed, Embase, Scopus, and 
      ClinicalTrials.gov were searched from inception to November 21, 2020. We included 
      studies comparing glycosylated hemoglobin (HbA1c) or fasting blood glucose (FBG) 
      among individuals with diabetes treated with and without PPI therapy as an add-on 
      to standard therapy. Studies evaluating the risk of incident diabetes among 
      individuals taking PPI were assessed. We performed dual independent review, data 
      extraction, and quality assessment. Weighted mean differences between groups or 
      relative risks were imputed using random-effects models. RESULTS: Seven studies 
      (n = 342) for glycemic control and 5 studies (n = 244 439) for risk of incident 
      diabetes were included. Compared with standard therapy, add-on PPI was associated 
      with a significant decrease in HbA1c (WMD, -0.36 %; 95% CI, -0.68 to -0.05; 
      P = 0.025) and FBG (WMD, -10.0 mg/dL; 95% CI, -19.4 to -0.6; P = 0.037). PPI use 
      did not reduce the risk of incident diabetes (pooled RR, 1.10; 95% CI, 0.89 to 
      1.34; P = 0.385). CONCLUSION: Add-on PPI improved glycemic indices among 
      individuals with diabetes but did not alter the risk of incident diabetes. The 
      effects of PPI on glycemic control should be considered when prescribing antacids 
      to patients with diabetes.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Peng, Carol Chiung-Hui
AU  - Peng CC
AUID- ORCID: 0000-0003-2352-6374
AD  - Department of Internal Medicine, University of Maryland Medical Center Midtown 
      Campus, Baltimore, MarylandUSA.
FAU - Tu, Yu-Kang
AU  - Tu YK
AUID- ORCID: 0000-0002-2461-474X
AD  - Institute of Epidemiology and Preventive Medicine, College of Public Health, 
      National Taiwan University, TaipeiTaiwan.
AD  - Department of Dentistry, National Taiwan University Hospital and School of 
      Dentistry, National Taiwan University, TaipeiTaiwan.
AD  - Research Center of Big Data and Meta-analysis, Wan Fang Hospital, Taipei Medical 
      University, TaipeiTaiwan.
FAU - Lee, Gin Yi
AU  - Lee GY
AD  - Department of Medicine, Danbury Hospital, Danbury, ConnecticutUSA.
FAU - Chang, Rachel Huai-En
AU  - Chang RH
AUID- ORCID: 0000-0002-5880-9537
AD  - Johns Hopkins Bloomberg School of Public Health, Baltimore, MarylandUSA.
FAU - Huang, Yuting
AU  - Huang Y
AUID- ORCID: 0000-0001-9986-5124
AD  - Department of Internal Medicine, University of Maryland Medical Center Midtown 
      Campus, Baltimore, MarylandUSA.
FAU - Bukhari, Khulood
AU  - Bukhari K
AUID- ORCID: 0000-0001-7343-0501
AD  - Department of Internal Medicine, University of Maryland Medical Center Midtown 
      Campus, Baltimore, MarylandUSA.
FAU - Tsai, Yao-Chou
AU  - Tsai YC
AUID- ORCID: 0000-0002-2833-5609
AD  - Department of Urology, School of Medicine, College of Medicine, Taipei Medical 
      University, TaipeiTaiwan.
AD  - Department of Urology, Taipei Medical University Hospital, Taipei Medical 
      University, TaipeiTaiwan.
FAU - Fu, Yunting
AU  - Fu Y
AD  - Health Sciences and Human Services Library, University of Maryland, Baltimore, 
      MDUSA.
FAU - Huang, Huei-Kai
AU  - Huang HK
AUID- ORCID: 0000-0003-3612-653X
AD  - Institute of Epidemiology and Preventive Medicine, College of Public Health, 
      National Taiwan University, TaipeiTaiwan.
AD  - Departments of Family Medicine and Medical Research, Hualien Tzu Chi Hospital, 
      Buddhist Tzu Chi Medical Foundation, HualienTaiwan.
FAU - Munir, Kashif M
AU  - Munir KM
AUID- ORCID: 0000-0002-1075-1284
AD  - Division of Endocrinology, Diabetes and Nutrition, University of Maryland School 
      of Medicine, Baltimore, MarylandUSA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Diabetes Mellitus/*drug therapy/epidemiology
MH  - Glycemic Control/*methods
MH  - Humans
MH  - Prognosis
MH  - Proton Pump Inhibitors/*therapeutic use
OTO - NOTNLM
OT  - diabetes mellitus
OT  - glucose-lowering effect
OT  - incretin
OT  - proton pump inhibitor
EDAT- 2021/06/26 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/06/25 12:18
PHST- 2021/02/27 00:00 [received]
PHST- 2021/06/26 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/06/25 12:18 [entrez]
AID - 6298561 [pii]
AID - 10.1210/clinem/dgab353 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2021 Oct 21;106(11):3354-3366. doi: 
      10.1210/clinem/dgab353.