PMID- 34170412
OWN - NLM
STAT- MEDLINE
DCOM- 20220329
LR  - 20220701
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 37
IP  - 1
DP  - 2022 Jan
TI  - Maternal antibiotic exposure during pregnancy is a risk factor for 
      community-acquired urinary tract infection caused by extended-spectrum 
      beta-lactamase-producing bacteria in infants.
PG  - 163-170
LID - 10.1007/s00467-021-05163-z [doi]
AB  - BACKGROUND: This study aimed to investigate the risk factors for 
      community-acquired urinary tract infection (UTI) caused by extended-spectrum 
      beta-lactamase (ESBL)-positive bacteria in infants. METHODS: We retrospectively 
      reviewed the medical records of infants aged < 1 year with first UTI from 2018 to 
      2019 at two tertiary centers in Korea. Data analyzed included clinical findings, 
      birth history, delivery mode, milk type, use of postpartum care center, and 
      previous use of antibiotics both in the patient and mother. RESULTS: Of 265 
      patients, 62 (23.4%) were diagnosed with first UTI caused by ESBL-positive 
      bacteria at the median age of 3.6 (interquartile range (IQR) 2.3-5.4) months. 
      Maternal use of antibiotics during pregnancy (29.0 vs. 10.3%, p < 0.001) and 
      Klebsiella species (19.4% vs. 4.9%, p < 0.001) were significantly associated with 
      ESBL-positive UTIs and remained valid in the multivariate analysis (odds ratio 
      [OR], 3.40; 95% confidence interval [CI] 1.61-7.19, p = 0.001, and OR 5.26; 95% 
      CI 2.03-13.13, p = 0.001, respectively). Previous antibiotic exposure of 
      patients, previous hospitalization, prematurity, delivery mode, milk type, and 
      use of postpartum care center were not significantly different between 
      ESBL-positive and ESBL-negative groups. With respect to the clinical course of 
      UTI, the ESBL-positive group presented a higher number of blood leukocytes (p = 
      0.041) and longer hospital stay (p < 0.001) than the ESBL-negative group. 
      CONCLUSIONS: About one-fourth of infantile UTI cases were ESBL-positive. Prenatal 
      antibiotic exposure of mothers and Klebsiella species were associated with 
      community-acquired UTI caused by ESBL-positive bacteria.
CI  - (c) 2021. IPNA.
FAU - Kim, Ji Hyun
AU  - Kim JH
AD  - Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, 
      Republic of Korea.
AD  - Department of Pediatrics, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Lee, Juyoung
AU  - Lee J
AUID- ORCID: 0000-0001-7548-2284
AD  - Department of Pediatrics, Inha University Hospital, Incheon, Republic of Korea.
FAU - Kim, Dong Hyun
AU  - Kim DH
AUID- ORCID: 0000-0001-9883-0229
AD  - Department of Pediatrics, Inha University Hospital, Incheon, Republic of Korea.
FAU - Park, Ji Young
AU  - Park JY
AUID- ORCID: 0000-0002-6777-0494
AD  - Department of Pediatrics, Chung-Ang University Hospital, Seoul, Republic of 
      Korea.
FAU - Lee, Hyunju
AU  - Lee H
AUID- ORCID: 0000-0003-0107-0724
AD  - Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, 
      Republic of Korea.
AD  - Department of Pediatrics, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kang, Hee Gyung
AU  - Kang HG
AUID- ORCID: 0000-0001-8323-5320
AD  - Department of Pediatrics, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
AD  - Department of Pediatrics, Seoul National University Children's Hospital, Seoul, 
      Republic of Korea.
AD  - Kidney Research Institute, Medical Research Center, Seoul National University 
      College of Medicine, Seoul, Republic of Korea.
AD  - Wide River Institute of Immunology, Seoul National University, Hongcheon, 
      Republic of Korea.
FAU - Ahn, Yo Han
AU  - Ahn YH
AUID- ORCID: 0000-0002-8185-4408
AD  - Department of Pediatrics, Seoul National University College of Medicine, Seoul, 
      Republic of Korea. yhahn@snu.ac.kr.
AD  - Department of Pediatrics, Seoul National University Children's Hospital, Seoul, 
      Republic of Korea. yhahn@snu.ac.kr.
AD  - Kidney Research Institute, Medical Research Center, Seoul National University 
      College of Medicine, Seoul, Republic of Korea. yhahn@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210625
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Anti-Bacterial Agents)
RN  - EC 3.5.2.6 (beta-Lactamases)
SB  - IM
CIN - Pediatr Nephrol. 2022 May;37(5):1167-1168. PMID: 35118537
MH  - *Anti-Bacterial Agents/adverse effects
MH  - Bacteria/enzymology
MH  - *Community-Acquired Infections/epidemiology/microbiology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Urinary Tract Infections/epidemiology/microbiology
MH  - beta-Lactamases/metabolism
OTO - NOTNLM
OT  - Infants
OT  - Klebsiella
OT  - Multiple antibacterial drug resistance
OT  - Prenatal care
OT  - Risk factors
OT  - Urinary tract infection
EDAT- 2021/06/26 06:00
MHDA- 2022/03/30 06:00
CRDT- 2021/06/25 12:21
PHST- 2021/01/29 00:00 [received]
PHST- 2021/05/28 00:00 [accepted]
PHST- 2021/05/23 00:00 [revised]
PHST- 2021/06/26 06:00 [pubmed]
PHST- 2022/03/30 06:00 [medline]
PHST- 2021/06/25 12:21 [entrez]
AID - 10.1007/s00467-021-05163-z [pii]
AID - 10.1007/s00467-021-05163-z [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2022 Jan;37(1):163-170. doi: 10.1007/s00467-021-05163-z. Epub 
      2021 Jun 25.