PMID- 34170455
OWN - NLM
STAT- MEDLINE
DCOM- 20211108
LR  - 20211108
IS  - 2095-0225 (Electronic)
IS  - 2095-0217 (Linking)
VI  - 15
IP  - 5
DP  - 2021 Oct
TI  - Outcomes of haploidentical bone marrow transplantation in patients with severe 
      aplastic anemia-II that progressed from non-severe acquired aplastic anemia.
PG  - 718-727
LID - 10.1007/s11684-020-0807-4 [doi]
AB  - Severe aplastic anemia II (SAA-II) progresses from non-severe aplastic anemia 
      (NSAA). The unavailability of efficacious treatment has prompted the need for 
      haploidentical bone marrow transplantation (haplo-BMT) in patients lacking a 
      human leukocyte antigen (HLA)-matched donor. This study aimed to investigate the 
      efficacy of haplo-BMT for patients with SAA-II. Twenty-two patients were included 
      and followed up, and FLU/BU/CY/ATG was used as conditioning regimen. Among these 
      patients, 21 were successfully engrafted, 19 of whom survived after haplo-BMT. 
      Four patients experienced grade II-IV aGvHD, including two with grade III-IV 
      aGvHD. Six patients experienced chronic GvHD, among whom four were mild and two 
      were moderate. Twelve patients experienced infections during BMT. One was 
      diagnosed with post-transplant lymphoproliferative disorder and one with probable 
      EBV disease, and both recovered after rituximab infusion. Haplo-BMT achieved 
      3-year overall survival and disease-free survival rate of 86.4% +/- 0.73% after a 
      median follow-up of 42 months, indicating its effectiveness as a salvage therapy. 
      These promising outcomes may support haplo-BMT as an alternative treatment 
      strategy for patients with SAA-II lacking HLA-matched donors.
CI  - (c) 2021. Higher Education Press.
FAU - Liu, Hongchen
AU  - Liu H
AD  - Department of Hematology, Liaoning Medical Center for Hematopoietic Stem Cell 
      Transplantation, Dalian Key Laboratory of Hematology, Liaoning Key Laboratory of 
      Hematopoietic Stem Cell Transplantation and Translational Medicine, Diamond Bay 
      Institute of Hematology, the Second Hospital of Dalian Medical University, 
      Dalian, 116027, China.
FAU - Zheng, Xiaoli
AU  - Zheng X
AD  - Department of Hematology, Air Force Medical Center, PLA, Beijing, 100142, China.
FAU - Zhang, Chengtao
AU  - Zhang C
AD  - Department of Hematology, Liaoning Medical Center for Hematopoietic Stem Cell 
      Transplantation, Dalian Key Laboratory of Hematology, Liaoning Key Laboratory of 
      Hematopoietic Stem Cell Transplantation and Translational Medicine, Diamond Bay 
      Institute of Hematology, the Second Hospital of Dalian Medical University, 
      Dalian, 116027, China.
FAU - Xie, Jiajun
AU  - Xie J
AD  - Department of Hematology, Liaoning Medical Center for Hematopoietic Stem Cell 
      Transplantation, Dalian Key Laboratory of Hematology, Liaoning Key Laboratory of 
      Hematopoietic Stem Cell Transplantation and Translational Medicine, Diamond Bay 
      Institute of Hematology, the Second Hospital of Dalian Medical University, 
      Dalian, 116027, China.
FAU - Gao, Beibei
AU  - Gao B
AD  - Department of Hematology, Liaoning Medical Center for Hematopoietic Stem Cell 
      Transplantation, Dalian Key Laboratory of Hematology, Liaoning Key Laboratory of 
      Hematopoietic Stem Cell Transplantation and Translational Medicine, Diamond Bay 
      Institute of Hematology, the Second Hospital of Dalian Medical University, 
      Dalian, 116027, China.
FAU - Shao, Jing
AU  - Shao J
AD  - Department of Hematology, Liaoning Medical Center for Hematopoietic Stem Cell 
      Transplantation, Dalian Key Laboratory of Hematology, Liaoning Key Laboratory of 
      Hematopoietic Stem Cell Transplantation and Translational Medicine, Diamond Bay 
      Institute of Hematology, the Second Hospital of Dalian Medical University, 
      Dalian, 116027, China.
AD  - Department of Environmental Health and Toxicology, Liaoning Medical Center for 
      Hematopoietic Stem Cell Transplantation, Liaoning Key Laboratory of Hematopoietic 
      Stem Cell Transplantation and Translational Medicine, School of Public Health, 
      Dalian Medical University, Dalian, 116044, China.
FAU - Yang, Yan
AU  - Yang Y
AD  - Department of Hematology, Liaoning Medical Center for Hematopoietic Stem Cell 
      Transplantation, Dalian Key Laboratory of Hematology, Liaoning Key Laboratory of 
      Hematopoietic Stem Cell Transplantation and Translational Medicine, Diamond Bay 
      Institute of Hematology, the Second Hospital of Dalian Medical University, 
      Dalian, 116027, China. yangyanxyfs@sina.com.
FAU - Wang, Hengxiang
AU  - Wang H
AD  - Department of Hematology, Air Force Medical Center, PLA, Beijing, 100142, China. 
      wanghengxiang123@aliyun.com.
FAU - Yan, Jinsong
AU  - Yan J
AD  - Department of Hematology, Liaoning Medical Center for Hematopoietic Stem Cell 
      Transplantation, Dalian Key Laboratory of Hematology, Liaoning Key Laboratory of 
      Hematopoietic Stem Cell Transplantation and Translational Medicine, Diamond Bay 
      Institute of Hematology, the Second Hospital of Dalian Medical University, 
      Dalian, 116027, China. yanjsdmu@126.com.
LA  - eng
PT  - Journal Article
DEP - 20210625
PL  - China
TA  - Front Med
JT  - Frontiers of medicine
JID - 101549428
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Anemia, Aplastic/therapy
MH  - Bone Marrow Transplantation
MH  - *Graft vs Host Disease
MH  - HLA Antigens
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Transplantation Conditioning
OTO - NOTNLM
OT  - haploidentical bone marrow transplantation
OT  - non-severe acquired aplastic anemia
OT  - outcomes
OT  - severe aplastic anemia
EDAT- 2021/06/26 06:00
MHDA- 2021/11/09 06:00
CRDT- 2021/06/25 12:23
PHST- 2020/01/22 00:00 [received]
PHST- 2020/05/29 00:00 [accepted]
PHST- 2021/06/26 06:00 [pubmed]
PHST- 2021/11/09 06:00 [medline]
PHST- 2021/06/25 12:23 [entrez]
AID - 10.1007/s11684-020-0807-4 [pii]
AID - 10.1007/s11684-020-0807-4 [doi]
PST - ppublish
SO  - Front Med. 2021 Oct;15(5):718-727. doi: 10.1007/s11684-020-0807-4. Epub 2021 Jun 
      25.