PMID- 34171070
OWN - NLM
STAT- MEDLINE
DCOM- 20211028
LR  - 20220531
IS  - 2066-8279 (Electronic)
IS  - 1220-0522 (Print)
IS  - 1220-0522 (Linking)
VI  - 61
IP  - 4
DP  - 2020 Oct-Dec
TI  - The immunoexpression of MMP-1 and MMP-13 in eyelid basal cell carcinoma.
PG  - 1221-1226
LID - 10.47162/RJME.61.4.23 [doi]
AB  - Basal cell carcinoma (BCC) is the most frequent human malignancy and at the same 
      time the most frequent periocular malignancy, representing almost 80% of all 
      non-melanoma skin cancers and 90% of eyelid cancers. The study included 50 cases 
      of eyelid BCC, out of which 41 were nodular BCC (NBCC) and nine were infiltrative 
      BCC (IBCC), with various Breslow scores (BS) and primary tumor (pT) category. We 
      analyzed the immunoexpression of matrix metalloproteinases (MMPs) 1 and 13 in the 
      tumoral epithelial component (TEC) and inflammatory stromal component (ISC) of 
      BCC in relation to the two histopathological parameters. The immunoreaction for 
      MMP-1 was identified in 41 (82%) cases and for MMP-13 in 46 (92%) cases both in 
      the TEC and ISC of both types of BCC. The statistical analysis revealed that both 
      collagenases had positive/high scores significantly associated with advanced BS. 
      For MMP-1, there were statistical associations in TEC related to IBCC and high pT 
      category, while MMP-13 only revealed statistical association in ISC with high pT. 
      The presence of collagenase MMP-1 and MMP-13 expression in a high number of 
      cases, both in TEC and ISC, confirms their intervention in the tumor progression 
      and proposes these MMPs as potential targets in antineoplastic therapy.
FAU - Mercut, Irina Maria
AU  - Mercut IM
AD  - Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania; 
      astepan76@yahoo.com.
FAU - Simionescu, Cristiana Eugenia
AU  - Simionescu CE
FAU - Stepan, Alex Emilian
AU  - Stepan AE
FAU - Andreiana, Bianca Catalina
AU  - Andreiana BC
FAU - Ciurea, Ana Maria
AU  - Ciurea AM
FAU - Mercut, Razvan
AU  - Mercut R
FAU - Ciurea, Marius Eugen
AU  - Ciurea ME
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Rom J Morphol Embryol
JT  - Romanian journal of morphology and embryology = Revue roumaine de morphologie et 
      embryologie
JID - 9112454
RN  - EC 3.4.24.- (Matrix Metalloproteinase 13)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
SB  - IM
MH  - *Carcinoma, Basal Cell
MH  - Eyelids
MH  - Humans
MH  - Matrix Metalloproteinase 1
MH  - Matrix Metalloproteinase 13
MH  - *Skin Neoplasms
PMC - PMC8343475
COIS- The authors declare that they have no conflict of interests.
EDAT- 2021/06/26 06:00
MHDA- 2021/10/29 06:00
PMCR- 2020/10/01
CRDT- 2021/06/25 17:22
PHST- 2021/06/25 17:22 [entrez]
PHST- 2021/06/26 06:00 [pubmed]
PHST- 2021/10/29 06:00 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - 61042012211226 [pii]
AID - 10.47162/RJME.61.4.23 [doi]
PST - ppublish
SO  - Rom J Morphol Embryol. 2020 Oct-Dec;61(4):1221-1226. doi: 10.47162/RJME.61.4.23.