PMID- 34171325
OWN - NLM
STAT- MEDLINE
DCOM- 20210804
LR  - 20210804
IS  - 1873-7528 (Electronic)
IS  - 0149-7634 (Linking)
VI  - 128
DP  - 2021 Sep
TI  - Neurobiological correlates of cue-reactivity in alcohol-use disorders: A 
      voxel-wise meta-analysis of fMRI studies.
PG  - 294-310
LID - S0149-7634(21)00273-6 [pii]
LID - 10.1016/j.neubiorev.2021.06.031 [doi]
AB  - Altered brain responses to alcohol-associated stimuli are a neural hallmark of 
      alcohol-use disorder (AUD) and a promising target for pharmacotherapy. However, 
      findings in cue-reactivity based functional MRI (fMRI) studies are inconclusive. 
      To investigate the neural substrates of cue-reactivity and their relevance to 
      treatment outcomes, alcohol craving and relapse in AUD patients, we performed 
      five meta-analyses using signed differential mapping software. Our meta-analysis 
      revealed that alcohol cues evoke greater cue-reactivity than neutral cues in the 
      mesocorticolimbic circuit and lower reactivity in the parietal and temporal 
      regions in AUD patients. Compared to controls, AUD individuals displayed 
      hyperactivations in the medial prefrontal cortex and anterior/middle part of the 
      cingulate cortex. After receiving AUD treatment, AUD patients exhibited greater 
      activations in the precentral gyrus but reduced activations in the bilateral 
      caudate nucleus, insula, right DLPFC, and left superior frontal gyrus. No 
      significant results were found in cue-reactivity correlates of alcohol craving 
      and relapse. Our results implicate cue-induced abnormalities in 
      corticostriatal-limbic circuits may underline the pathophysiology of AUD, and 
      have translational value for treatment development.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Zeng, Jianguang
AU  - Zeng J
AD  - School of Economics and Business Administration, Chongqing University, Chongqing, 
      400044, China.
FAU - Yu, Shuxian
AU  - Yu S
AD  - School of Economics and Business Administration, Chongqing University, Chongqing, 
      400044, China.
FAU - Cao, Hengyi
AU  - Cao H
AD  - Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, 
      Hempstead, NY, USA; Division of Psychiatry Research, Zucker Hillside Hospital, 
      Glen Oaks, NY, USA.
FAU - Su, Yueyue
AU  - Su Y
AD  - School of Public Policy and Administration, Chongqing University, Chongqing, 
      400044, China.
FAU - Dong, Zaiquan
AU  - Dong Z
AD  - Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital of 
      Sichuan University, Chengdu, 610041, China.
FAU - Yang, Xun
AU  - Yang X
AD  - School of Public Policy and Administration, Chongqing University, Chongqing, 
      400044, China. Electronic address: yangxunjg@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210623
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - *Alcoholism/diagnostic imaging
MH  - Brain/diagnostic imaging
MH  - Cues
MH  - Ethanol
MH  - Humans
MH  - *Magnetic Resonance Imaging
OTO - NOTNLM
OT  - Alcohol-use disorder
OT  - Cue-reactivity
OT  - Mesocorticolimbic circuit
OT  - Meta
OT  - fMRI
EDAT- 2021/06/26 06:00
MHDA- 2021/08/05 06:00
CRDT- 2021/06/25 20:11
PHST- 2021/02/22 00:00 [received]
PHST- 2021/05/31 00:00 [revised]
PHST- 2021/06/19 00:00 [accepted]
PHST- 2021/06/26 06:00 [pubmed]
PHST- 2021/08/05 06:00 [medline]
PHST- 2021/06/25 20:11 [entrez]
AID - S0149-7634(21)00273-6 [pii]
AID - 10.1016/j.neubiorev.2021.06.031 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2021 Sep;128:294-310. doi: 
      10.1016/j.neubiorev.2021.06.031. Epub 2021 Jun 23.