PMID- 34174799
OWN - NLM
STAT- MEDLINE
DCOM- 20221130
LR  - 20221130
IS  - 1303-6165 (Electronic)
IS  - 1300-0144 (Linking)
VI  - 51
IP  - 5
DP  - 2021 Oct
TI  - Serum antiganglioside antibodies in patients with autoimmune limbic encephalitis.
PG  - 2570-2574
LID - 10.3906/sag-2101-348 [doi]
AB  - BACKGROUND: Ganglioside antibodies are identified not only in patients with 
      inflammatory neuropathies but also several central nervous system disorders and 
      paraneoplastic neuropathies. Our aim was to investigate whether ganglioside 
      antibodies are found in autoimmune encephalitis patients and may function as a 
      diagnostic and prognostic biomarker. METHODS: Sera and cerebrospinal fluid (CSF) 
      samples of 33 patients fulfilling the criteria for probable autoimmune 
      encephalitis were collected within the first week of clinical manifestation. None 
      of the patients had evident symptoms and findings of peripheral polyneuropathy. 
      Well-characterized antineuronal and paraneoplastic antibodies were investigated 
      in sera and CSF and antiganglioside (antiGM1, GM2, GM3, GD1a, GD1b, GT1b, and 
      GQ1b) IgG and IgM antibodies were measured in sera using commercial immunoblots. 
      RESULTS: Twenty-eight of 33 autoimmune encephalitis patients displayed antibodies 
      against neuronal surface or onco-neural antigens with N-methyl-D-aspartate 
      receptor (NMDAR), glutamic acid decarboxylase (GAD) and Hu antibodies being the 
      most prevalent. While no antiganglioside IgG antibodies were found, 4 patients (2 
      anti-NMDAR+, 1 anti-GAD+ and 1 antibody negative) with autoimmune limbic 
      encephalitis displayed anti-GM1, anti-GM2, anti-GM3 or anti-GQ1b IgM antibodies. 
      There was no apparent association between antiganglioside positivity and clinical 
      and demographic features. DISCUSSION: Serum ganglioside IgM antibodies may 
      infrequently emerge during the clinical course of autoimmune limbic encephalitis 
      without evident polyneuropathy. Absence of the IgG response suggests that these 
      antibodies might have developed as a hyperacute immune response to neuro-axonal 
      destruction. Nevertheless, potential impact of ganglioside antibodies on axonal 
      degeneration and neuronal loss in limbic encephalitis pends to be further 
      investigated.
FAU - Oktar, Ayla Culha
AU  - Oktar AC
AD  - Department of Neurology, Haseki Training and Research Hospital, Istanbul, Turkey.
FAU - Selcuk, Ozlem
AU  - Selcuk O
AD  - Department of Neurology, Haseki Training and Research Hospital, Istanbul, Turkey.
FAU - Tunc, Cansu Elmas
AU  - Tunc CE
AD  - Department of Neurology, Haseki Training and Research Hospital, Istanbul, Turkey.
FAU - Isildak, Senol
AU  - Isildak S
AD  - Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, 
      Istanbul University, Istanbul, Turkey.
FAU - Sanli, Elif
AU  - Sanli E
AD  - Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, 
      Istanbul University, Istanbul, Turkey.
FAU - Yilmaz, Vuslat
AU  - Yilmaz V
AD  - Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, 
      Istanbul University, Istanbul, Turkey.
FAU - Tuzun, Birgul Bastan
AU  - Tuzun BB
AD  - Department of Neurology, Haseki Training and Research Hospital, Istanbul, Turkey.
FAU - Kurtuncu, Murat
AU  - Kurtuncu M
AD  - Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Cokar, Ayse Ozlem
AU  - Cokar AO
AD  - Department of Neurology, Haseki Training and Research Hospital, Istanbul, Turkey.
FAU - Tuzun, Erdem
AU  - Tuzun E
AD  - Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, 
      Istanbul University, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20211021
PL  - Turkey
TA  - Turk J Med Sci
JT  - Turkish journal of medical sciences
JID - 9441758
RN  - 0 (Gangliosides)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Immunoglobulin G)
RN  - Autoimmune limbic encephalitis
SB  - IM
MH  - Humans
MH  - *Limbic Encephalitis
MH  - Gangliosides
MH  - Immunoglobulin M
MH  - Immunoglobulin G
MH  - *Polyneuropathies
OTO - NOTNLM
OT  - Ganglioside
OT  - antibody
OT  - autoimmune encephalitis
OT  - autoimmunity
OT  - paraneoplastic
EDAT- 2021/06/28 06:00
MHDA- 2022/12/01 06:00
CRDT- 2021/06/27 00:08
PHST- 2021/01/28 00:00 [received]
PHST- 2021/06/24 00:00 [accepted]
PHST- 2021/06/28 06:00 [pubmed]
PHST- 2022/12/01 06:00 [medline]
PHST- 2021/06/27 00:08 [entrez]
AID - 10.3906/sag-2101-348 [doi]
PST - ppublish
SO  - Turk J Med Sci. 2021 Oct;51(5):2570-2574. doi: 10.3906/sag-2101-348. Epub 2021 
      Oct 21.