PMID- 34174839
OWN - NLM
STAT- MEDLINE
DCOM- 20210702
LR  - 20210702
IS  - 1471-2334 (Electronic)
IS  - 1471-2334 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Jun 26
TI  - Frosted branch angiitis due to cytomegalovirus-associated unmasking immune 
      reconstitution inflammatory syndrome: a case report and literature review.
PG  - 613
LID - 10.1186/s12879-021-06311-4 [doi]
LID - 613
AB  - BACKGROUND: Cytomegalovirus (CMV) retinitis is a common opportunistic infection 
      in patients with acquired immunodeficiency syndrome. The common funduscopic 
      manifestations are haemorrhagic necrotising variety and granular variety. Frosted 
      branch angiitis (FBA), as a special form, when it occurred after antiretroviral 
      therapy(ART), could possibly be associated with immune reconstitution. We report 
      a case of FBA secondary to CMV infection-associated unmasking immune 
      reconstitution inflammatory syndrome (IRIS). CASE PRESENTATION: A 27-year-old man 
      with human immunodeficiency virus infection developed FBA after 35 days of ART. 
      The left Aqueous humour (AqH) tested positive for CMV DNA, and the patient was 
      diagnosed with CMV retinitis. The degree of intraocular inflammation was 
      reflected by increased levels of interleukin (IL)-6 and IL-8 in AqH. After 
      anti-CMV treatment and continuous ART for several months, his FBA and vision 
      significantly improved. CMV DNA became undetectable in the left AqH, and the IL-6 
      and IL-8 levels in AqH decreased. CONCLUSION: FBA could be a sign of 
      CMV-associated unmasking IRIS. Anti-CMV treatment alone or combination with 
      steroid treatment may be administered, depending on the changes in CMV DNA load 
      and immunologic profile of AqH.
FAU - Tang, Shi
AU  - Tang S
AD  - Infectious Diseases Department, The First Affiliated Hospital of China Medical 
      University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, 
      Liaoning Province, China.
FAU - Zhao, Ning
AU  - Zhao N
AD  - Department of Ophthalmology, The First Affiliated Hospital of China Medical 
      University, Shenyang, Liaoning Province, China.
FAU - Wang, Li Yang
AU  - Wang LY
AD  - Department of Gastroenterology, The sixth People's Hospital of Shenyang, 
      Shenyang, Liaoning Province, China.
FAU - Wen, Ying
AU  - Wen Y
AUID- ORCID: 0000-0002-9775-6351
AD  - Infectious Diseases Department, The First Affiliated Hospital of China Medical 
      University, No. 155, Nanjing North Street, Heping District, Shenyang, 110001, 
      Liaoning Province, China. wenying666466@163.com.
LA  - eng
GR  - 3110119068 to W.Y./Double First Class University Plan/
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20210626
PL  - England
TA  - BMC Infect Dis
JT  - BMC infectious diseases
JID - 100968551
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/complications
MH  - Adult
MH  - Cytomegalovirus/immunology
MH  - Cytomegalovirus Retinitis/*complications/diagnosis/immunology
MH  - Diagnosis, Differential
MH  - HIV
MH  - HIV Infections/*complications/diagnosis/immunology/virology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/complications/*diagnosis
MH  - Male
MH  - Vasculitis/complications/*diagnosis/immunology
PMC - PMC8236202
OTO - NOTNLM
OT  - Anti-cytomegalovirus treatment
OT  - Case report
OT  - Frosted branch angiitis
OT  - Unmasking immune reconstitution inflammatory syndrome
COIS- The authors declare that they have no competing interests.
EDAT- 2021/06/28 06:00
MHDA- 2021/07/03 06:00
PMCR- 2021/06/26
CRDT- 2021/06/27 20:23
PHST- 2020/12/31 00:00 [received]
PHST- 2021/06/10 00:00 [accepted]
PHST- 2021/06/27 20:23 [entrez]
PHST- 2021/06/28 06:00 [pubmed]
PHST- 2021/07/03 06:00 [medline]
PHST- 2021/06/26 00:00 [pmc-release]
AID - 10.1186/s12879-021-06311-4 [pii]
AID - 6311 [pii]
AID - 10.1186/s12879-021-06311-4 [doi]
PST - epublish
SO  - BMC Infect Dis. 2021 Jun 26;21(1):613. doi: 10.1186/s12879-021-06311-4.