PMID- 34175588
OWN - NLM
STAT- MEDLINE
DCOM- 20220203
LR  - 20220203
IS  - 1878-5891 (Electronic)
IS  - 0378-5955 (Linking)
VI  - 408
DP  - 2021 Sep 1
TI  - Deficient sensory and cognitive processing in children with cochlear implants: An 
      event-related potential study.
PG  - 108295
LID - S0378-5955(21)00129-5 [pii]
LID - 10.1016/j.heares.2021.108295 [doi]
AB  - Compared with children having normal hearing (NH), those with cochlear implants 
      (CIs) perform poorly in spoken language comprehension which involves both 
      low-level acoustic encoding and higher-level cognitive processing. Here, we 
      performed an electroencephalography study to portray this brain dynamics of 
      speech perception in CI children. We presented a Mandarin Chinese monosyllable or 
      four-syllable idiom to CI and NH children, and infrequently varied its lexical 
      tone to form a novel monosyllable or pseudo-idiom in an oddball paradigm. The 
      tone contrast embedded in the monosyllables evoked similar mismatch negativities 
      (MMNs) in CI and NH children at an early stage (~200 ms). However, the amplitude 
      of the MMN evoked by the tone contrast in the idiom context was significantly 
      lower in CI children than in NH children. Furthermore, robust late discriminative 
      negativity (LDN) at a late stage (~500 ms) was found only in NH children, but not 
      in CI children. The MMN and LDN findings indicate deficits of low-level acoustic 
      encoding in a complex context (such as an idiom) and higher-level cognitive 
      processing in CI children, respectively. Both deficient sensory and cognitive 
      processing may contribute to the speech perception difficulties in CI children.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Hu, Zhe
AU  - Hu Z
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital 
      of USTC, Division of Life Sciences and Medicine, University of Science and 
      Technology of China, Hefei, Anhui, 230001, China.
FAU - Sun, Jia-Qiang
AU  - Sun JQ
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital 
      of USTC, Division of Life Sciences and Medicine, University of Science and 
      Technology of China, Hefei, Anhui, 230001, China.
FAU - Guan, Rui-Rui
AU  - Guan RR
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital 
      of USTC, Division of Life Sciences and Medicine, University of Science and 
      Technology of China, Hefei, Anhui, 230001, China; Auditory Research Laboratory, 
      School of Life Sciences, University of Science and Technology of China, Hefei, 
      Anhui, 230027, China.
FAU - Chen, Lin
AU  - Chen L
AD  - Auditory Research Laboratory, School of Life Sciences, University of Science and 
      Technology of China, Hefei, Anhui, 230027, China; CAS Key Laboratory of Brain 
      Function and Diseases, School of Life Sciences, University of Science and 
      Technology of China, Hefei, Anhui, 230027, China.
FAU - Sun, Jing-Wu
AU  - Sun JW
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital 
      of USTC, Division of Life Sciences and Medicine, University of Science and 
      Technology of China, Hefei, Anhui, 230001, China. Electronic address: 
      entsun@ustc.edu.cn.
FAU - Guo, Xiao-Tao
AU  - Guo XT
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital 
      of USTC, Division of Life Sciences and Medicine, University of Science and 
      Technology of China, Hefei, Anhui, 230001, China; CAS Key Laboratory of Brain 
      Function and Diseases, School of Life Sciences, University of Science and 
      Technology of China, Hefei, Anhui, 230027, China. Electronic address: 
      gxt2012@mail.ustc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210617
PL  - Netherlands
TA  - Hear Res
JT  - Hearing research
JID - 7900445
SB  - IM
MH  - Acoustic Stimulation
MH  - *Cochlear Implantation
MH  - *Cochlear Implants
MH  - Cognition
MH  - Electroencephalography
MH  - Evoked Potentials
MH  - Humans
MH  - *Speech Perception
OTO - NOTNLM
OT  - Cochlear implant
OT  - Idiom
OT  - Late discriminative negativity
OT  - Mismatch negativity
OT  - Monosyllable
OT  - Speech processing
COIS- Declarations of Competing Interest None.
EDAT- 2021/06/28 06:00
MHDA- 2022/02/04 06:00
CRDT- 2021/06/27 20:49
PHST- 2020/09/25 00:00 [received]
PHST- 2021/06/01 00:00 [revised]
PHST- 2021/06/07 00:00 [accepted]
PHST- 2021/06/28 06:00 [pubmed]
PHST- 2022/02/04 06:00 [medline]
PHST- 2021/06/27 20:49 [entrez]
AID - S0378-5955(21)00129-5 [pii]
AID - 10.1016/j.heares.2021.108295 [doi]
PST - ppublish
SO  - Hear Res. 2021 Sep 1;408:108295. doi: 10.1016/j.heares.2021.108295. Epub 2021 Jun 
      17.