PMID- 34176074
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
VI  - 74
IP  - 2
DP  - 2021 Nov
TI  - Risk of type 2 diabetes mellitus in polycystic ovary syndrome is associated with 
      obesity: a meta-analysis of observational studies.
PG  - 245-253
LID - 10.1007/s12020-021-02801-2 [doi]
AB  - PURPOSE: The exact risk of type 2 diabetes mellitus (T2DM) in women with 
      polycystic ovary syndrome (PCOS) is unknown. It is also unclear if obesity 
      independently increases T2DM risk in this population. The aim of this study was 
      to systematically review and synthesize the best available evidence regarding the 
      association between PCOS and T2DM, stratified according to obesity status. 
      METHODS: A comprehensive search was conducted in PubMed, CENTRAL and Scopus 
      databases up to October 31, 2020. Data are expressed as relative risk (RR) with 
      95% confidence interval (CI). The I(2) index was employed for heterogeneity. 
      RESULTS: The eligibility criteria were fulfilled by 23 studies (319,780 
      participants; 60,336 PCOS and 8847 type 2 diabetes cases). Women with PCOS 
      demonstrated a higher risk of T2DM than those without PCOS (RR 3.45, 95% CI, 
      2.95-4.05, p < 0.001; I(2) 81.6%). This risk remained significant both in studies 
      matched or unmatched for participants' age. With regard to body mass index (BMI), 
      the RR for developing T2DM in obese and non-obese PCOS women compared with their 
      non-PCOS counterparts was 3.24 (95% CI 2.25-4.65; p < 0.001; I(2) 30.9%) and 1.62 
      (95% CI 0.14-18.50; p = 0.70; I(2) 89.9%), respectively. The RR for developing 
      T2DM was 3.85 (95% CI 1.99-7.43; p < 0.001; I(2) 46.2%) in obese compared with 
      non-obese women with PCOS. This was also the case for overweight compared with 
      lean women with PCOS. CONCLUSIONS: Women with PCOS present an increased risk of 
      T2DM compared with non-PCOS women only if they are obese/overweight.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Anagnostis, Panagiotis
AU  - Anagnostis P
AUID- ORCID: 0000-0002-8949-4312
AD  - Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, 
      Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. 
      anagnwstis.pan@yahoo.gr.
FAU - Paparodis, Rodis D
AU  - Paparodis RD
AD  - Center for Diabetes and Endocrine Research, University of Toledo College of 
      Medicine and Life Sciences, Toledo, OH, USA.
FAU - Bosdou, Julia K
AU  - Bosdou JK
AD  - Unit for Human Reproduction, 1st Department of Obstetrics and Gynecology, Medical 
      School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
FAU - Bothou, Christina
AU  - Bothou C
AD  - Department of Endocrinology, Diabetology and Clinical Nutrition, University 
      Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland.
FAU - Macut, Djuro
AU  - Macut D
AD  - Clinic for Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, 
      University of Belgrade, Belgrade, Serbia.
FAU - Goulis, Dimitrios G
AU  - Goulis DG
AD  - Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, 
      Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
FAU - Livadas, Sarantis
AU  - Livadas S
AD  - Endocrine Unit, Metropolitan Hospital, Athens, Greece.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20210626
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
SB  - IM
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Obesity/complications/epidemiology
MH  - Overweight
MH  - *Polycystic Ovary Syndrome/complications/epidemiology
OTO - NOTNLM
OT  - Obesity
OT  - PCOS
OT  - Polycystic ovary syndrome
OT  - Type 2 diabetes mellitus
EDAT- 2021/06/28 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/06/27 21:09
PHST- 2021/04/26 00:00 [received]
PHST- 2021/06/13 00:00 [accepted]
PHST- 2021/06/28 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/06/27 21:09 [entrez]
AID - 10.1007/s12020-021-02801-2 [pii]
AID - 10.1007/s12020-021-02801-2 [doi]
PST - ppublish
SO  - Endocrine. 2021 Nov;74(2):245-253. doi: 10.1007/s12020-021-02801-2. Epub 2021 Jun 
      26.