PMID- 34177193
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230107
IS  - 0975-9476 (Print)
IS  - 0976-2809 (Electronic)
IS  - 0975-9476 (Linking)
VI  - 13
IP  - 1
DP  - 2022 Jan-Mar
TI  - Exploring AyuGenomics approach for understanding COVID-19 predisposition and 
      progression.
PG  - 100463
LID - S0975-9476(21)00111-X [pii]
LID - 10.1016/j.jaim.2021.06.003 [doi]
AB  - Recent reports on COVID-19 suggest that, the susceptibility to COVID-19 infection 
      and its progression have a genetic predisposition. Majorly associated genetic 
      variants are found in human leukocyte antigen (HLA), angiotensin convertase 
      enzyme (ACE; rs1799752: ACE2; rs73635825), and transmembrane protease serine 2 
      (TMPRSS-2; rs12329760) genes. Identifying highly prone population having these 
      variants is imperative for determining COVID-19 therapeutic strategies. Ayurveda 
      (Indian traditional system of medicine) concept of Prakriti holds potential to 
      predict genomic and phenotypic variations. Reported work on Prakriti correlates 
      HLA-DR alleles with three broad phenotypes (Tridosha) described in Ayurveda 
      (AyuGenomics). This is suggestive of differences in immune responses in 
      individuals with specific constitutions. Therefore, the reported studies provide 
      clues for clinically relevant hypotheses to be tested in systematic studies. The 
      proposed approach of Ayurveda-based phenotype screening may offer a way ahead to 
      design customized strategies for management of COVID-19 based on differences in 
      Prakriti, immune response, and drug response. However, this needs clinical 
      evaluation of the relation between Prakriti and genetic or phenotypic variants in 
      COVID-19 prone and resistant populations.
CI  - (c) 2021 The Authors.
FAU - Bhat, Vedika
AU  - Bhat V
AD  - AYUSH - Center of Excellence, Center for Complementary and Integrative Health, 
      Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, 
      Pune, 411 007, India.
FAU - Borse, Swapnil
AU  - Borse S
AD  - AYUSH - Center of Excellence, Center for Complementary and Integrative Health, 
      Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, 
      Pune, 411 007, India.
FAU - Chavan-Gautam, Preeti
AU  - Chavan-Gautam P
AD  - AYUSH - Center of Excellence, Center for Complementary and Integrative Health, 
      Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, 
      Pune, 411 007, India.
FAU - Joshi, Kalpana
AU  - Joshi K
AD  - Department of Biotechnology, Sinhgad College of Engineering, Affiliated to SPPU, 
      Pune, 411041, India. Electronic address: joshikalpana@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210617
PL  - United States
TA  - J Ayurveda Integr Med
JT  - Journal of Ayurveda and integrative medicine
JID - 101551404
PMC - PMC8221020
OTO - NOTNLM
OT  - AyuGenomics
OT  - Ayurveda
OT  - Genomics
OT  - Integrative medicine
OT  - Personalized medicine
OT  - SARS-CoV-2
EDAT- 2021/06/29 06:00
MHDA- 2021/06/29 06:01
PMCR- 2021/06/17
CRDT- 2021/06/28 05:49
PHST- 2021/03/06 00:00 [received]
PHST- 2021/04/24 00:00 [revised]
PHST- 2021/06/04 00:00 [accepted]
PHST- 2021/06/29 06:00 [pubmed]
PHST- 2021/06/29 06:01 [medline]
PHST- 2021/06/28 05:49 [entrez]
PHST- 2021/06/17 00:00 [pmc-release]
AID - S0975-9476(21)00111-X [pii]
AID - 100463 [pii]
AID - 10.1016/j.jaim.2021.06.003 [doi]
PST - ppublish
SO  - J Ayurveda Integr Med. 2022 Jan-Mar;13(1):100463. doi: 
      10.1016/j.jaim.2021.06.003. Epub 2021 Jun 17.