PMID- 34178865
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 2251-6581 (Print)
IS  - 2251-6581 (Electronic)
IS  - 2251-6581 (Linking)
VI  - 20
IP  - 1
DP  - 2021 Jun
TI  - Non-vascular contributing factors of diabetic foot ulcer severity in national 
      referral hospital of Indonesia.
PG  - 805-813
LID - 10.1007/s40200-021-00827-x [doi]
AB  - PURPOSE: Diabetic foot ulcer (DFU) is a common chronic complication of type 2 
      diabetes mellitus (T2DM) in Indonesia, with a prevalence of 7.3%. However, the 
      characteristics of these patients remain unclear. We investigated the 
      characteristics of patients with DFU without peripheral arterial disease (PAD) 
      and analyzed non-vascular factors related to severity of DFU in a tertiary care 
      national referral hospital in Indonesia. METHODS: This was a cross-sectional 
      study including 123 hemodynamically stable DFU patients without PAD recruited 
      from Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia from 
      2010-2015. RESULTS: DFU patients were predominantly over 50 years old (75.6%) and 
      diagnosed with T2DM for 5 years with poor glycemic control (82.7%) and peripheral 
      neuropathy (91.3%). Most patients had anemia (86.7%), leukocytosis (84.6%), and 
      were undernourished, as characterized by a low lipid profile (90.8%) and 
      hypoalbuminemia (83.7%). Most had extensive size of ulcer at the initial visit, 
      with a median size of 16.23 (2.92-60.16) cm(2). Ulcers were mostly located of the 
      forefoot (62.5%) and were caused by mechanical trauma (46.2%). Bivariate analysis 
      revealed that significant factors for the development of DFU were related to DFU 
      size, including duration of T2DM (p = 0.04), leukocyte levels (p =  < 0.01), and 
      thrombocyte levels (p =  < 0.01). Multivariate analysis showed leucocyte 
      (p = 0.03) and thrombocyte (p = 0.023) had significantly correlated with DFU 
      severity. CONCLUSION: Leucocyte and thrombocyte may be the greatest contributing 
      non-vascular factors for severity of DFU in Indonesia.
CI  - (c) Springer Nature Switzerland AG 2021.
FAU - Yunir, Em
AU  - Yunir E
AUID- ORCID: 0000-0002-2004-9050
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. 
      Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas 
      Indonesia, Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
AD  - Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical 
      Education and Research Institute, Faculty of Medicine, Universitas Indonesia, 
      Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
FAU - Tahapary, Dicky L
AU  - Tahapary DL
AUID- ORCID: 0000-0002-4048-5159
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. 
      Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas 
      Indonesia, Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
AD  - Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical 
      Education and Research Institute, Faculty of Medicine, Universitas Indonesia, 
      Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
FAU - Tarigan, Tri Juli Edi
AU  - Tarigan TJE
AUID- ORCID: 0000-0001-6086-700X
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. 
      Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas 
      Indonesia, Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
AD  - Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical 
      Education and Research Institute, Faculty of Medicine, Universitas Indonesia, 
      Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
FAU - Harbuwono, Dante Saksono
AU  - Harbuwono DS
AUID- ORCID: 0000-0002-6006-2719
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. 
      Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas 
      Indonesia, Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
AD  - Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical 
      Education and Research Institute, Faculty of Medicine, Universitas Indonesia, 
      Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
FAU - Oktavianda, Yoga Dwi
AU  - Oktavianda YD
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. 
      Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas 
      Indonesia, Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
FAU - Kristanti, Melly
AU  - Kristanti M
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. 
      Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas 
      Indonesia, Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
FAU - Iswati, Eni
AU  - Iswati E
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. 
      Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas 
      Indonesia, Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
FAU - Sarumpaet, Angela
AU  - Sarumpaet A
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. 
      Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas 
      Indonesia, Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
FAU - Soewondo, Pradana
AU  - Soewondo P
AUID- ORCID: 0000-0003-3674-7934
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. 
      Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas 
      Indonesia, Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
AD  - Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical 
      Education and Research Institute, Faculty of Medicine, Universitas Indonesia, 
      Jakarta, Indonesia. GRID: grid.9581.5. ISNI: 0000000120191471
LA  - eng
PT  - Journal Article
DEP - 20210612
PL  - Switzerland
TA  - J Diabetes Metab Disord
JT  - Journal of diabetes and metabolic disorders
JID - 101590741
PMC - PMC8212257
OTO - NOTNLM
OT  - Diabetic foot ulcer
OT  - Leucocyte
OT  - Non-vascular factor
OT  - Thrombocyte
COIS- Competing of interestThere is no conflict of interest in this research.
EDAT- 2021/06/29 06:00
MHDA- 2021/06/29 06:01
PMCR- 2022/06/12
CRDT- 2021/06/28 06:04
PHST- 2021/02/11 00:00 [received]
PHST- 2021/05/30 00:00 [accepted]
PHST- 2021/06/28 06:04 [entrez]
PHST- 2021/06/29 06:00 [pubmed]
PHST- 2021/06/29 06:01 [medline]
PHST- 2022/06/12 00:00 [pmc-release]
AID - 827 [pii]
AID - 10.1007/s40200-021-00827-x [doi]
PST - epublish
SO  - J Diabetes Metab Disord. 2021 Jun 12;20(1):805-813. doi: 
      10.1007/s40200-021-00827-x. eCollection 2021 Jun.