PMID- 34181081
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20211125
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 58
IP  - 12
DP  - 2021 Dec
TI  - Association of remnant cholesterol with chronic kidney disease in middle-aged and 
      elderly Chinese: a population-based study.
PG  - 1615-1625
LID - 10.1007/s00592-021-01765-z [doi]
AB  - AIMS: Limited data regarding the association between remnant cholesterol (RC) and 
      chronic kidney disease (CKD), largely based on an estimated glomerular filtration 
      rate (eGFR) of < 60 mL/min/1.73 m(2) (low eGFR), have yielded inconsistent 
      results, and no report has demonstrated the relationship of RC with CKD [defined 
      as low eGFR and/or albuminuria (defined as urinary albumin-to-creatinine ratio 
      (ACR) >/= 30 mg/g)] in Chinese general middle-aged and elderly population. Hence, 
      we aimed to investigate the association between RC and CKD in such population. 
      METHODS: In total, 7356 Chinese participants aged >/= 40 years were recruited from 
      five regional communities in Luzhou city between May 2011 and December 2011. 
      Fasting RC was calculated from the lipid profile measured by standard laboratory 
      procedures. Multivariate logistic regression models were used to evaluate the 
      possible association between RC and CKD. RESULTS: Participants in the highest 
      quartile of RC had higher body mass index, systolic and diastolic blood pressure, 
      total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), 
      fasting and 2-h postload blood glucose, glycated hemoglobin A1C, prevalence of 
      prediabetes, type 2 diabetes mellitus (T2DM), hypertension, CKD, albuminuria, low 
      eGFR, and lower high-density lipoprotein cholesterol (HDL-C) and eGFR compared 
      with those in the lowest quartile (all P for trend < 0.01). Multivariate logistic 
      regression analysis demonstrated that the risk of CKD gradually increased across 
      RC quartiles (P for trend < 0.01), and participants in the highest quartile of RC 
      were at a significantly increased risk of prevalent CKD compared to those in the 
      lowest quartile in total subjects (odds rate: 1.344, 95% confidence intervals 
      1.097-1.648, P < 0.01). In subgroup analysis, significant relation between RC 
      level and increased risk of prevalent CKD was detected in women, subjects with 
      overweight/obesity, non-prediabetes, hypertension, normal HDL-C, appropriate and 
      high LDL-C, and without cardiovascular disease (CVD) events after multiple 
      adjustments. CONCLUSIONS: Higher RC is independently associated with increased 
      risk of prevalent CKD, and RC might serve as a new risk biomarker for CKD in a 
      general middle-aged and elderly Chinese population, especially in women, subjects 
      with overweight/obesity, non-prediabetes, hypertension, normal HDL-C, appropriate 
      and high LDL-C, and without CVD events.
CI  - (c) 2021. Springer-Verlag Italia S.r.l., part of Springer Nature.
FAU - Yan, Pijun
AU  - Yan P
AUID- ORCID: 0000-0001-6692-2401
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, 646000, Sichuan, China.
FAU - Xu, Yong
AU  - Xu Y
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, 646000, Sichuan, China.
FAU - Miao, Ying
AU  - Miao Y
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, 646000, Sichuan, China.
FAU - Bai, Xue
AU  - Bai X
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, 646000, Sichuan, China.
FAU - Wu, Yuru
AU  - Wu Y
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, 646000, Sichuan, China.
FAU - Tang, Qian
AU  - Tang Q
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, 646000, Sichuan, China.
FAU - Zhang, Zhihong
AU  - Zhang Z
AD  - Department of General Medicine, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, 646000, Sichuan, China.
FAU - Yang, Jiong
AU  - Yang J
AD  - Southwest Medical University, Luzhou, 646000, Sichuan, China.
FAU - Wan, Qin
AU  - Wan Q
AD  - Department of Endocrinology, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, 646000, Sichuan, China. wanqin231@126.com.
LA  - eng
GR  - 2012ZX09303006-001/grants from the National Key New Drug Creation and 
      Manufacturing Program of Ministry of Science and Technology/
PT  - Journal Article
DEP - 20210628
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Aged
MH  - China/epidemiology
MH  - Cholesterol
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Middle Aged
MH  - *Renal Insufficiency, Chronic/epidemiology
MH  - Risk Factors
OTO - NOTNLM
OT  - Albuminuria
OT  - Chronic kidney disease
OT  - Estimated glomerular filtration rate
OT  - General population
OT  - Remnant cholesterol
EDAT- 2021/06/29 06:00
MHDA- 2021/11/26 06:00
CRDT- 2021/06/28 12:27
PHST- 2021/03/28 00:00 [received]
PHST- 2021/06/14 00:00 [accepted]
PHST- 2021/06/29 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2021/06/28 12:27 [entrez]
AID - 10.1007/s00592-021-01765-z [pii]
AID - 10.1007/s00592-021-01765-z [doi]
PST - ppublish
SO  - Acta Diabetol. 2021 Dec;58(12):1615-1625. doi: 10.1007/s00592-021-01765-z. Epub 
      2021 Jun 28.