PMID- 34182427
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1471-4973 (Electronic)
IS  - 1471-4892 (Linking)
VI  - 59
DP  - 2021 Aug
TI  - Exercise as a drug for glucose management and prevention in type 2 diabetes 
      mellitus.
PG  - 95-102
LID - S1471-4892(21)00067-9 [pii]
LID - 10.1016/j.coph.2021.05.006 [doi]
AB  - Physical inactivity and sedentary behavior are risk factors for type 2 diabetes 
      mellitus (T2DM). Therefore, physical exercise (PE) together with medical 
      treatment might be considered as a key strategy to counteract T2DM. Glycemic 
      control is a central objective in the prevention and management of T2DM, and PE 
      might be able to substantially affect the processes that determine it. Just like 
      a drug, exercise can be dosed based on the characteristics of the individual to 
      increase its benefits and reduce side effects. In this brief review, the 
      mechanisms underlying the effects of PE on glucose metabolism in muscle are 
      illustrated, and the effects of modulation of the parameters characterizing this 
      atypical "drug" on glucose homeostasis are described.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Sgro, Paolo
AU  - Sgro P
AD  - Department of Movement, Human and Health Sciences, University of Rome "Foro 
      Italico", Rome, Italy.
FAU - Emerenziani, Gian Pietro
AU  - Emerenziani GP
AD  - Department of Experimental and Clinical Medicine, University of Catanzaro "Magna 
      Graecia", Catanzaro, Italy.
FAU - Antinozzi, Cristina
AU  - Antinozzi C
AD  - Department of Movement, Human and Health Sciences, University of Rome "Foro 
      Italico", Rome, Italy.
FAU - Sacchetti, Massimo
AU  - Sacchetti M
AD  - Department of Movement, Human and Health Sciences, University of Rome "Foro 
      Italico", Rome, Italy.
FAU - Di Luigi, Luigi
AU  - Di Luigi L
AD  - Department of Movement, Human and Health Sciences, University of Rome "Foro 
      Italico", Rome, Italy. Electronic address: luigi.diluigi@uniroma4.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210626
PL  - England
TA  - Curr Opin Pharmacol
JT  - Current opinion in pharmacology
JID - 100966133
RN  - 0 (Pharmaceutical Preparations)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/drug therapy/prevention & control
MH  - Exercise
MH  - Glucose
MH  - Humans
MH  - *Pharmaceutical Preparations
COIS- Conflict of interest statement Nothing declared.
EDAT- 2021/06/29 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/06/28 20:30
PHST- 2021/03/25 00:00 [received]
PHST- 2021/05/19 00:00 [revised]
PHST- 2021/05/25 00:00 [accepted]
PHST- 2021/06/29 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/06/28 20:30 [entrez]
AID - S1471-4892(21)00067-9 [pii]
AID - 10.1016/j.coph.2021.05.006 [doi]
PST - ppublish
SO  - Curr Opin Pharmacol. 2021 Aug;59:95-102. doi: 10.1016/j.coph.2021.05.006. Epub 
      2021 Jun 26.