PMID- 34182994
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 1741-7007 (Electronic)
IS  - 1741-7007 (Linking)
VI  - 19
IP  - 1
DP  - 2021 Jun 28
TI  - Do all mice smell the same? Chemosensory cues from inbred and wild mouse strains 
      elicit stereotypic sensory representations in the accessory olfactory bulb.
PG  - 133
LID - 10.1186/s12915-021-01064-7 [doi]
LID - 133
AB  - BACKGROUND: For many animals, chemosensory cues are vital for social and 
      defensive interactions and are primarily detected and processed by the 
      vomeronasal system (VNS). These cues are often inherently associated with 
      ethological meaning, leading to stereotyped behaviors. Thus, one would expect 
      consistent representation of these stimuli across different individuals. However, 
      individuals may express different arrays of vomeronasal sensory receptors and may 
      vary in the pattern of connections between those receptors and projection neurons 
      in the accessory olfactory bulb (AOB). In the first part of this study, we 
      address the ability of individuals to form consistent representations despite 
      these potential sources of variability. The second part of our study is motivated 
      by the fact that the majority of research on VNS physiology involves the use of 
      stimuli derived from inbred animals. Yet, it is unclear whether neuronal 
      representations of inbred-derived stimuli are similar to those of more 
      ethologically relevant wild-derived stimuli. RESULTS: First, we compared sensory 
      representations to inbred, wild-derived, and wild urine stimuli in the AOBs of 
      males from two distinct inbred strains, using them as proxies for individuals. We 
      found a remarkable similarity in stimulus representations across the two strains. 
      Next, we compared AOB neuronal responses to inbred, wild-derived, and wild 
      stimuli, again using male inbred mice as subjects. Employing various measures of 
      neuronal activity, we show that wild-derived and wild stimuli elicit responses 
      that are broadly similar to those from inbred stimuli: they are not considerably 
      stronger or weaker, they show similar levels of sexual dimorphism, and when 
      examining population-level activity, cluster with inbred mouse stimuli. 
      CONCLUSIONS: Despite strain-specific differences and apparently random 
      connectivity, the AOB can maintain stereotypic sensory representations for broad 
      stimulus categories, providing a substrate for common stereotypical behaviors. In 
      addition, despite many generations of inbreeding, AOB representations capture the 
      key ethological features (i.e., species and sex) of wild-derived and wild 
      counterparts. Beyond these broad similarities, representations of stimuli from 
      wild mice are nevertheless distinct from those elicited by inbred mouse stimuli, 
      suggesting that laboratory inbreeding has indeed resulted in marked modifications 
      of urinary secretions.
FAU - Bansal, Rohini
AU  - Bansal R
AD  - Department of Medical Neurobiology, Institute for Medical Research Israel Canada, 
      Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
FAU - Nagel, Maximilian
AU  - Nagel M
AD  - Department of Chemosensation, Institute for Biology II, RWTH Aachen University, 
      Aachen, Germany.
FAU - Stopkova, Romana
AU  - Stopkova R
AD  - BIOCEV group, Department of Zoology, Faculty of Science, Charles University, 
      Prague, Czech Republic.
FAU - Sofer, Yizhak
AU  - Sofer Y
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
FAU - Kimchi, Tali
AU  - Kimchi T
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
FAU - Stopka, Pavel
AU  - Stopka P
AD  - BIOCEV group, Department of Zoology, Faculty of Science, Charles University, 
      Prague, Czech Republic.
FAU - Spehr, Marc
AU  - Spehr M
AD  - Department of Chemosensation, Institute for Biology II, RWTH Aachen University, 
      Aachen, Germany.
FAU - Ben-Shaul, Yoram
AU  - Ben-Shaul Y
AUID- ORCID: 0000-0002-0407-4221
AD  - Department of Medical Neurobiology, Institute for Medical Research Israel Canada, 
      Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. 
      yoramb@ekmd.huji.ac.il.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210628
PL  - England
TA  - BMC Biol
JT  - BMC biology
JID - 101190720
SB  - IM
MH  - Animals
MH  - Cues
MH  - Male
MH  - Mice
MH  - *Olfactory Bulb
MH  - Sensory Receptor Cells
MH  - Smell
MH  - Stereotyped Behavior
MH  - Vomeronasal Organ
PMC - PMC8240315
OTO - NOTNLM
OT  - Accessory olfactory bulb
OT  - Innate responses
OT  - Stimulus representations
OT  - Vomeronasal system
OT  - Wild mouse stimuli
COIS- The authors declare that they have no competing interests.
EDAT- 2021/06/30 06:00
MHDA- 2022/02/01 06:00
PMCR- 2021/06/28
CRDT- 2021/06/29 05:39
PHST- 2021/02/03 00:00 [received]
PHST- 2021/06/06 00:00 [accepted]
PHST- 2021/06/29 05:39 [entrez]
PHST- 2021/06/30 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/06/28 00:00 [pmc-release]
AID - 10.1186/s12915-021-01064-7 [pii]
AID - 1064 [pii]
AID - 10.1186/s12915-021-01064-7 [doi]
PST - epublish
SO  - BMC Biol. 2021 Jun 28;19(1):133. doi: 10.1186/s12915-021-01064-7.