PMID- 34183525
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 1531-6971 (Electronic)
IS  - 1070-5287 (Linking)
VI  - 27
IP  - 5
DP  - 2021 Sep 1
TI  - Interstitial pneumonia with autoimmune features: from research classification to 
      diagnosis.
PG  - 374-387
LID - 10.1097/MCP.0000000000000802 [doi]
AB  - PURPOSE OF REVIEW: The term interstitial pneumonia with autoimmune features 
      (IPAF) was first proposed by an international task force in 2015 as a research 
      classification to standardise nomenclature regarding patients with idiopathic 
      interstitial pneumonia and features of connective tissue disease. However, how 
      the use of this term and its proposed definition translates to clinical practice 
      remains uncertain. This review will provide a comprehensive overview of studies 
      of IPAF cohorts to date, discuss the consideration of IPAF as a distinct 
      diagnostic entity and outline a suggested approach to patient management. RECENT 
      FINDINGS: Considerable heterogeneity exists between published IPAF cohorts, with 
      some cohorts exhibiting similarities to those with connective tissue 
      disease-associated interstitial lung disease (CTD-ILD), and others more similar 
      to idiopathic interstitial pneumonias including idiopathic pulmonary fibrosis 
      (IPF). Little data exist to inform the management of patients who fulfil the IPAF 
      criteria. Preliminary data supports pragmatic management of these patients as 
      having a working clinical diagnosis of either idiopathic interstitial pneumonia 
      or CTD-ILD. Future research studies into this approach are required. SUMMARY: The 
      term IPAF, and its definition, have been of fundamental benefit to facilitating 
      research in this diverse patient group. However, to date, there remain many 
      unanswered questions regarding their natural histories and response to treatment.
CI  - Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Glenn, Laura M
AU  - Glenn LM
AD  - Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, 
      Camperdown, NSW, Australia.
AD  - The University of Sydney School of Medicine (Central Clinical School), Sydney, 
      NSW, Australia.
FAU - Pugashetti, Janelle V
AU  - Pugashetti JV
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal 
      Medicine, University of California, Davis, California, USA.
FAU - Oldham, Justin
AU  - Oldham J
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal 
      Medicine, University of California, Davis, California, USA.
FAU - Corte, Tamera J
AU  - Corte TJ
AD  - Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, 
      Camperdown, NSW, Australia.
AD  - The University of Sydney School of Medicine (Central Clinical School), Sydney, 
      NSW, Australia.
AD  - NHMRC Centre of Research Excellence in Pulmonary Fibrosis, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Pulm Med
JT  - Current opinion in pulmonary medicine
JID - 9503765
SB  - IM
MH  - *Autoimmune Diseases/diagnosis
MH  - *Connective Tissue Diseases/diagnosis
MH  - Humans
MH  - *Idiopathic Interstitial Pneumonias/diagnosis
MH  - *Idiopathic Pulmonary Fibrosis/diagnosis
MH  - *Lung Diseases, Interstitial/diagnosis
EDAT- 2021/06/30 06:00
MHDA- 2021/10/16 06:00
CRDT- 2021/06/29 05:55
PHST- 2021/06/30 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/06/29 05:55 [entrez]
AID - 00063198-202109000-00014 [pii]
AID - 10.1097/MCP.0000000000000802 [doi]
PST - ppublish
SO  - Curr Opin Pulm Med. 2021 Sep 1;27(5):374-387. doi: 10.1097/MCP.0000000000000802.