PMID- 34183688 OWN - NLM STAT- MEDLINE DCOM- 20211101 LR - 20240402 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 11 IP - 1 DP - 2021 Jun 28 TI - Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults. PG - 13394 LID - 10.1038/s41598-021-91038-0 [doi] LID - 13394 AB - Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and cognitive decline in older adults are still limited. 504 older adults (median age 75 years) who expressed memory complaints were selected from the Multidomain Alzheimer's Preventive Trial (MAPT) and were classified as normal cognition (NC) or mild cognitive impairment (MCI). Cognitive functions were measured as mini mental state examination (MMSE) and composite cognitive score (CCS) over a 4-year period. Plasma NfL was measured at the first or the second year of the MAPT. Mixed-effects linear models were performed to evaluate cross-sectional and longitudinal associations. In the whole population, higher plasma NfL was cross-sectionally associated with lower cognitive functions (MMSE: beta = - 0.007, 95% CI [- 0.013, - 0.001]; CCS: beta = - 0.003, 95% CI [- 0.006, - 0.001]). In adults with MCI, but not NC, higher plasma NfL was associated with lower CCS at the cross-sectional level (beta = - 0.003, 95% CI [- 0.005, - 0.0002]). The upper quartile NfL group further demonstrated more over time decline in CCS (beta = - 0.07, 95% CI [- 0.12, - 0.01]) under the MCI status. Plasma NfL can be a promising biomarker of progressive cognition decline in older adults with MCI. FAU - He, Lingxiao AU - He L AD - Gerontopole de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, 37 Allees Jules Guesdes, 31000, Toulouse, France. lingxiao.he@hotmail.com. FAU - Morley, John E AU - Morley JE AD - Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA. FAU - Aggarwal, Geetika AU - Aggarwal G AD - Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA. AD - Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University, St. Louis, MO, USA. FAU - Nguyen, Andrew D AU - Nguyen AD AD - Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA. AD - Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University, St. Louis, MO, USA. FAU - Vellas, Bruno AU - Vellas B AD - Gerontopole de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, 37 Allees Jules Guesdes, 31000, Toulouse, France. AD - CERPOP, Inserm 1295, Universite de Toulouse, UPS, 31000, Toulouse, France. FAU - de Souto Barreto, Philipe AU - de Souto Barreto P AD - Gerontopole de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, 37 Allees Jules Guesdes, 31000, Toulouse, France. AD - CERPOP, Inserm 1295, Universite de Toulouse, UPS, 31000, Toulouse, France. CN - MAPT/DSA Group LA - eng PT - Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210628 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Amyloid beta-Peptides) RN - 0 (Biomarkers) RN - 0 (Neurofilament Proteins) SB - IM MH - Aged MH - Aged, 80 and over MH - Alzheimer Disease/blood/pathology MH - Amyloid beta-Peptides/blood MH - Biomarkers/blood MH - Cognition/physiology MH - Cognitive Dysfunction/*blood/*pathology MH - Cross-Sectional Studies MH - Female MH - Humans MH - Intermediate Filaments/*metabolism MH - Male MH - Mental Status and Dementia Tests MH - Neurofilament Proteins/*blood PMC - PMC8238930 COIS- The authors declare no competing interests. FIR - Vellas, Bruno IR - Vellas B FIR - Guyonnet, Sophie IR - Guyonnet S FIR - Carrie, Isabelle IR - Carrie I FIR - Brigitte, Laureane IR - Brigitte L FIR - Faisant, Catherine IR - Faisant C FIR - Lala, Francoise IR - Lala F FIR - Delrieu, Julien IR - Delrieu J FIR - Villars, Helene IR - Villars H FIR - Combrouze, Emeline IR - Combrouze E FIR - Badufle, Carole IR - Badufle C FIR - Zueras, Audrey IR - Zueras A FIR - Andrieu, Sandrine IR - Andrieu S FIR - Cantet, Christelle IR - Cantet C FIR - Morin, Christophe IR - Morin C FIR - Van Kan, Gabor Abellan IR - Van Kan GA FIR - Dupuy, Charlotte IR - Dupuy C FIR - Rolland, Yves IR - Rolland Y FIR - Caillaud, Celine IR - Caillaud C FIR - Ousset, Pierre-Jean IR - Ousset PJ FIR - Lala, Francoise IR - Lala F FIR - Willis, Sherry IR - Willis S FIR - Belleville, Sylvie IR - Belleville S FIR - Gilbert, Brigitte IR - Gilbert B FIR - Fontaine, Francine IR - Fontaine F FIR - Dartigues, Jean-Francois IR - Dartigues JF FIR - Marcet, Isabelle IR - Marcet I FIR - Delva, Fleur IR - Delva F FIR - Foubert, Alexandra IR - Foubert A FIR - Cerda, Sandrine IR - Cerda S FIR - Marie-Noelle-Cuffi IR - Marie-Noelle-Cuffi FIR - Costes, Corinne IR - Costes C FIR - Rouaud, Olivier IR - Rouaud O FIR - Manckoundia, Patrick IR - Manckoundia P FIR - Quipourt, Valerie IR - Quipourt V FIR - Marilier, Sophie IR - Marilier S FIR - Franon, Evelyne IR - Franon E FIR - Bories, Lawrence IR - Bories L FIR - Pader, Marie-Laure IR - Pader ML FIR - Basset, Marie-France IR - Basset MF FIR - Lapoujade, Bruno IR - Lapoujade B FIR - Faure, Valerie IR - Faure V FIR - Tong, Michael Li Yung IR - Tong MLY FIR - Malick-Loiseau, Christine IR - Malick-Loiseau C FIR - Cazaban-Campistron, Evelyne IR - Cazaban-Campistron E FIR - Desclaux, Francoise IR - Desclaux F FIR - Blatge, Colette IR - Blatge C FIR - Dantoine, Thierry IR - Dantoine T FIR - Laubarie-Mouret, Cecile IR - Laubarie-Mouret C FIR - Saulnier, Isabelle IR - Saulnier I FIR - Clement, Jean-Pierre IR - Clement JP FIR - Picat, Marie-Agnes IR - Picat MA FIR - Bernard-Bourzeix, Laurence IR - Bernard-Bourzeix L FIR - Willebois, Stephanie IR - Willebois S FIR - Desormais, Ileana IR - Desormais I FIR - Cardinaud, Noelle IR - Cardinaud N FIR - Bonnefoy, Marc IR - Bonnefoy M FIR - Livet, Pierre IR - Livet P FIR - Rebaudet, Pascale IR - Rebaudet P FIR - Gedeon, Claire IR - Gedeon C FIR - Burdet, Catherine IR - Burdet C FIR - Terracol, Flavien IR - Terracol F FIR - Pesce, Alain IR - Pesce A FIR - Roth, Stephanie IR - Roth S FIR - Chaillou, Sylvie IR - Chaillou S FIR - Louchart, Sandrine IR - Louchart S FIR - Sudres, Kristel IR - Sudres K FIR - Lebrun, Nicolas IR - Lebrun N FIR - Barro-Belaygues, Nadege IR - Barro-Belaygues N FIR - Touchon, Jacques IR - Touchon J FIR - Bennys, Karim IR - Bennys K FIR - Gabelle, Audrey IR - Gabelle A FIR - Romano, Aurelia IR - Romano A FIR - Touati, Lynda IR - Touati L FIR - Marelli, Cecilia IR - Marelli C FIR - Pays, Cecile IR - Pays C FIR - Robert, Philippe IR - Robert P FIR - Le Duff, Franck IR - Le Duff F FIR - Gervais, Claire IR - Gervais C FIR - Gonfrier, Sebastien IR - Gonfrier S FIR - Gasnier, Yannick IR - Gasnier Y FIR - Bordes, Serge IR - Bordes S FIR - Begorre, Daniele IR - Begorre D FIR - Carpuat, Christian IR - Carpuat C FIR - Khales, Khaled IR - Khales K FIR - Lefebvre, Jean-Francois IR - Lefebvre JF FIR - Idrissi, Samira Misbah El IR - Idrissi SME FIR - Skolil, Pierre IR - Skolil P FIR - Salles, Jean-Pierre IR - Salles JP FIR - Dufouil, Carole IR - Dufouil C FIR - Lehericy, Stephane IR - Lehericy S FIR - Chupin, Marie IR - Chupin M FIR - Mangin, Jean-Francois IR - Mangin JF FIR - Bouhayia, Ali IR - Bouhayia A FIR - Allard, Michele IR - Allard M FIR - Ricolfi, Frederic IR - Ricolfi F FIR - Dubois, Dominique IR - Dubois D FIR - Martel, Marie Paule Bonceour IR - Martel MPB FIR - Cotton, Francois IR - Cotton F FIR - Bonafe, Alain IR - Bonafe A FIR - Chanalet, Stephane IR - Chanalet S FIR - Hugon, Francoise IR - Hugon F FIR - Bonneville, Fabrice IR - Bonneville F FIR - Cognard, Christophe IR - Cognard C FIR - Chollet, Francois IR - Chollet F FIR - Payoux, Pierre IR - Payoux P FIR - Voisin, Thierry IR - Voisin T FIR - Delrieu, Julien IR - Delrieu J FIR - Peiffer, Sophie IR - Peiffer S FIR - Hitzel, Anne IR - Hitzel A FIR - Allard, Michele IR - Allard M FIR - Zanca, Michel IR - Zanca M FIR - Monteil, Jacques IR - Monteil J FIR - Darcourt, Jacques IR - Darcourt J FIR - Molinier, Laurent IR - Molinier L FIR - Derumeaux, Helene IR - Derumeaux H FIR - Costa, Nadege IR - Costa N FIR - Perret, Bertrand IR - Perret B FIR - Vinel, Claire IR - Vinel C FIR - Caspar-Bauguil, Sylvie IR - Caspar-Bauguil S FIR - Olivier-Abbal, Pascale IR - Olivier-Abbal P FIR - Andrieu, Sandrine IR - Andrieu S FIR - Cantet, Christelle IR - Cantet C FIR - Coley, Nicola IR - Coley N EDAT- 2021/06/30 06:00 MHDA- 2021/11/03 06:00 PMCR- 2021/06/28 CRDT- 2021/06/29 06:06 PHST- 2021/02/10 00:00 [received] PHST- 2021/05/12 00:00 [accepted] PHST- 2021/06/29 06:06 [entrez] PHST- 2021/06/30 06:00 [pubmed] PHST- 2021/11/03 06:00 [medline] PHST- 2021/06/28 00:00 [pmc-release] AID - 10.1038/s41598-021-91038-0 [pii] AID - 91038 [pii] AID - 10.1038/s41598-021-91038-0 [doi] PST - epublish SO - Sci Rep. 2021 Jun 28;11(1):13394. doi: 10.1038/s41598-021-91038-0.