PMID- 34185501
OWN - NLM
STAT- MEDLINE
DCOM- 20210726
LR  - 20210726
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 13
IP  - 27
DP  - 2021 Jul 14
TI  - Bacterial Photoinactivation Using PLGA Electrospun Scaffolds.
PG  - 31406-31417
LID - 10.1021/acsami.1c02686 [doi]
AB  - The use of ultraviolet (UV) and blue irradiation to sterilize surfaces is well 
      established, but commercial applications would be enhanced if the light source is 
      replaced with ambient light. In this paper, it is shown that nanofibers can be 
      explored as an alternative methodology to UV and blue irradiation for bacterial 
      inactivation. It is demonstrated that this is indeed possible using spun 
      nanofibers of poly[lactic-co-(glycolic acid)] (PLGA). This work shows that PLGA 
      spun scaffolds can promote photoinactivation of Staphylococcus aureus and 
      Escherichia coli bacteria with ambient light or with laser irradiation at 630 nm. 
      With the optimized scaffold composition of PLGA85:15 nanofibers, the minimum 
      intensity required to kill the bacteria is much lower than in antimicrobial blue 
      light applications. The enhanced effect introduced by PLGA scaffolds is due to 
      their nanofiber structures since PLGA spun nanofibers were able to inactivate 
      both S. aureus and E. coli bacteria, but cast films had no effect. These findings 
      pave the way for an entirely different method to sterilize surfaces, which is 
      less costly and environmentally friendly than current procedures. In addition, 
      the scaffolds could also be used in cancer treatment with fewer side effects 
      since photosensitizers are not required.
FAU - Pereira, Aline O
AU  - Pereira AO
AD  - School of Arts, Sciences and Humanities, University of Sao Paulo (USP), Arlindo 
      Bettio Av., 1000, Sao Paulo 03828-000, Brazil.
FAU - Lopes, Isabella M I
AU  - Lopes IMI
AD  - School of Arts, Sciences and Humanities, University of Sao Paulo (USP), Arlindo 
      Bettio Av., 1000, Sao Paulo 03828-000, Brazil.
FAU - Silva, Thiago R
AU  - Silva TR
AD  - School of Arts, Sciences and Humanities, University of Sao Paulo (USP), Arlindo 
      Bettio Av., 1000, Sao Paulo 03828-000, Brazil.
FAU - Correa, Thaila Q
AU  - Correa TQ
AD  - Sao Carlos Institute of Physics, University of Sao Paulo (USP), Trabalhador 
      Sao-Carlense Av., 400, Sao Carlos 13560-970, Brazil.
FAU - Paschoalin, Rafaella T
AU  - Paschoalin RT
AD  - Sao Carlos Institute of Physics, University of Sao Paulo (USP), Trabalhador 
      Sao-Carlense Av., 400, Sao Carlos 13560-970, Brazil.
AD  - Nanotechnology National Laboratory for Agriculture (LNNA), Embrapa 
      Instrumentation, 15 de Novembro St., 1452, Sao Carlos 13560-970, Brazil.
FAU - Inada, Natalia M
AU  - Inada NM
AD  - Sao Carlos Institute of Physics, University of Sao Paulo (USP), Trabalhador 
      Sao-Carlense Av., 400, Sao Carlos 13560-970, Brazil.
FAU - Iermak, Ievgeniia
AU  - Iermak I
AUID- ORCID: 0000-0002-9922-3444
AD  - Sao Carlos Institute of Physics, University of Sao Paulo (USP), Trabalhador 
      Sao-Carlense Av., 400, Sao Carlos 13560-970, Brazil.
FAU - van Riel Neto, Francisco
AU  - van Riel Neto F
AD  - Institute of Physics, Federal University of Uberlandia (UFU), Joao Naves de Avila 
      Av., 2121, Uberlandia 38408-100, Brazil.
FAU - Araujo-Chaves, Juliana C
AU  - Araujo-Chaves JC
AD  - Center of Natural Sciences and HumanitiesFederal University of ABC (UFABC), dos 
      Estados Av., 5001, Santo Andre 09210-580, Brazil.
FAU - Marletta, Alexandre
AU  - Marletta A
AUID- ORCID: 0000-0003-1297-6839
AD  - Institute of Physics, Federal University of Uberlandia (UFU), Joao Naves de Avila 
      Av., 2121, Uberlandia 38408-100, Brazil.
FAU - Tozoni, Jose R
AU  - Tozoni JR
AD  - Institute of Physics, Federal University of Uberlandia (UFU), Joao Naves de Avila 
      Av., 2121, Uberlandia 38408-100, Brazil.
FAU - Mattoso, Luiz Henrique C
AU  - Mattoso LHC
AUID- ORCID: 0000-0001-7586-1014
AD  - Nanotechnology National Laboratory for Agriculture (LNNA), Embrapa 
      Instrumentation, 15 de Novembro St., 1452, Sao Carlos 13560-970, Brazil.
FAU - Bagnato, Vanderlei S
AU  - Bagnato VS
AD  - Sao Carlos Institute of Physics, University of Sao Paulo (USP), Trabalhador 
      Sao-Carlense Av., 400, Sao Carlos 13560-970, Brazil.
FAU - Nantes-Cardoso, Iseli L
AU  - Nantes-Cardoso IL
AUID- ORCID: 0000-0003-1434-3154
AD  - Center of Natural Sciences and HumanitiesFederal University of ABC (UFABC), dos 
      Estados Av., 5001, Santo Andre 09210-580, Brazil.
FAU - Oliveira, Osvaldo N Jr
AU  - Oliveira ON Jr
AUID- ORCID: 0000-0002-5399-5860
AD  - Sao Carlos Institute of Physics, University of Sao Paulo (USP), Trabalhador 
      Sao-Carlense Av., 400, Sao Carlos 13560-970, Brazil.
FAU - Campana, Patricia T
AU  - Campana PT
AUID- ORCID: 0000-0002-2337-6372
AD  - School of Arts, Sciences and Humanities, University of Sao Paulo (USP), Arlindo 
      Bettio Av., 1000, Sao Paulo 03828-000, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20210629
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
SB  - IM
MH  - *Electricity
MH  - Escherichia coli/drug effects/*physiology/radiation effects
MH  - Microbial Viability/*drug effects/radiation effects
MH  - Polylactic Acid-Polyglycolic Acid Copolymer/*chemistry/*pharmacology
MH  - Staphylococcus aureus/drug effects/*physiology/radiation effects
MH  - *Ultraviolet Rays
OTO - NOTNLM
OT  - PLGA
OT  - antimicrobial
OT  - bacterial photoinactivation
OT  - electrospun nanofibers
OT  - nanomaterial
EDAT- 2021/06/30 06:00
MHDA- 2021/07/27 06:00
CRDT- 2021/06/29 17:09
PHST- 2021/06/30 06:00 [pubmed]
PHST- 2021/07/27 06:00 [medline]
PHST- 2021/06/29 17:09 [entrez]
AID - 10.1021/acsami.1c02686 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2021 Jul 14;13(27):31406-31417. doi: 
      10.1021/acsami.1c02686. Epub 2021 Jun 29.