PMID- 34186077 OWN - NLM STAT- MEDLINE DCOM- 20211008 LR - 20220531 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 201 DP - 2021 Oct TI - Potential liver damage due to co-exposure to As, Cd, and Pb in mining areas: Association analysis and research trends from a Chinese perspective. PG - 111598 LID - S0013-9351(21)00892-6 [pii] LID - 10.1016/j.envres.2021.111598 [doi] AB - There is global concern regarding the public health hazards of environmental exposure to multiple toxic heavy metals. The effects of toxic heavy metals on liver function have been suggested in previous reports, but the association between exposure to multiple toxic heavy metals and liver function has not been elucidated. The aim of this study was to investigate the effects of exposure to multiple toxic heavy metals, arsenic(As), lead(Pb), and cadmium(Cd), on liver function through population-based and animal studies. A total of 3590 participants were enrolled from the mining areas in Western Hunan Province. The concentrations of As, Pb, and Cd in the urine and plasma samples were determined using quadrupole inductively coupled plasma mass spectrometry (ICP-MS). Bayesian kernel machine regression (BKMR) was employed for the joint association assay. An animal study was conducted to further verify the cumulative effects of metals on liver damage-related parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) levels. Research trends regarding toxic metals were also explored to obtain in-depth understanding of the current knowledge in this field. Typically, for single-exposure analysis, in most mines, Pb exhibited a significantly negative association with ALT levels, whereas for cumulative effects analysis, when As, Pb, and Cd concentrations were at the 50(th)percentile, a significantly negative effect on liver ALT levels was observed. Furthermore, animal studies have shown that co-exposure to As, Pb, and Cd could aggravate liver dysfunction in mice compared to that in the single-metal treated group (p < 0.05). From 1990 to 2019, 1965 projects relating to As, Pb, and Cd research have been initiated, and the total RMB(RenMingBi) funded was approximately 800 million in China, as opposed to 2500 projects in the US with an approximate amount of US$ 1 billion, which is substantially greater than that of China. Finally, from a global viewpoint, scientists should continue to substantially contribute to the field of heavy metal contamination through more extensive academic investigation, global cooperation, and the development of novel control methods. Overall, this study identified that elevated combined concentrations of As, Pb, and Cd were significantly negatively associated with liver function. CI - Copyright (c) 2021 Elsevier Inc. All rights reserved. FAU - Huang, Ruixue AU - Huang R AD - Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan Province, 410078, China. Electronic address: huangruixue@csu.edu.cn. FAU - Pan, Huiji AU - Pan H AD - Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan Province, 410078, China. Electronic address: 944145906@qq.com. FAU - Zhou, Meiling AU - Zhou M AD - Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan Province, 410078, China. FAU - Jin, Jing AU - Jin J AD - Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan Province, 410078, China. Electronic address: jingjinzz@163.com. FAU - Ju, Zhao AU - Ju Z AD - Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan Province, 410078, China. Electronic address: 717541810@qq.com. FAU - Ren, Guofeng AU - Ren G AD - Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan Province, 410078, China. Electronic address: renguofeng@csu.edu.cn. FAU - Shen, Minxue AU - Shen M AD - Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan Province, 410078, China; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: shenmx1988@csu.edu.cn. FAU - Zhou, Pingkun AU - Zhou P AD - Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, AMMS, Beijing, 100850, China. Electronic address: birm4th@163.com. FAU - Chen, Xiang AU - Chen X AD - Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: chenxiangck@126.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210627 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 00BH33GNGH (Cadmium) RN - 2P299V784P (Lead) SB - IM MH - Animals MH - Bayes Theorem MH - *Cadmium/toxicity MH - China MH - Humans MH - Lead/toxicity MH - *Liver Diseases MH - Mice OTO - NOTNLM OT - Association OT - Heavy metal OT - Liver function OT - Mixtures EDAT- 2021/06/30 06:00 MHDA- 2021/10/09 06:00 CRDT- 2021/06/29 20:11 PHST- 2020/10/21 00:00 [received] PHST- 2021/06/10 00:00 [revised] PHST- 2021/06/22 00:00 [accepted] PHST- 2021/06/30 06:00 [pubmed] PHST- 2021/10/09 06:00 [medline] PHST- 2021/06/29 20:11 [entrez] AID - S0013-9351(21)00892-6 [pii] AID - 10.1016/j.envres.2021.111598 [doi] PST - ppublish SO - Environ Res. 2021 Oct;201:111598. doi: 10.1016/j.envres.2021.111598. Epub 2021 Jun 27.