PMID- 34186156
OWN - NLM
STAT- MEDLINE
DCOM- 20220128
LR  - 20220128
IS  - 1879-0542 (Electronic)
IS  - 0165-2478 (Linking)
VI  - 237
DP  - 2021 Sep
TI  - Relevance of autoantibody profile with HLA-DRB1 and -DQB1 alleles in a group of 
      Iranian systemic lupus erythematosus patients.
PG  - 11-16
LID - S0165-2478(21)00098-5 [pii]
LID - 10.1016/j.imlet.2021.06.004 [doi]
AB  - BACKGROUND: One of the most relevant genetic components in systemic lupus 
      erythematosus (SLE) is human leukocyte antigen (HLA) gene complex which plays a 
      central role in autoimmune responses. This study aimed to explore the 
      associations of HLA-DRB1/-DQB1 alleles and haplotypes with SLE risk and the 
      appearance of autoantibodies in SLE disease. METHODS: A total of 127 SLE patients 
      and 153 ethnically matched healthy controls were enrolled. HLA-DRB1 and HLA-DQB1 
      alleles were determined by PCR-SSP method and then HLA alleles and haplotypes 
      frequencies were compared between two groups and among the patients in terms of 
      autoantibodies spectrum. RESULTS: We found that HLA-DRB1*03 and HLA-DRB1*16 
      alleles were significantly associated with increased risk (P = 0.008, P(C)=0.05 
      and P = 0.002, P(C)=0.02 respectively) and DRB1*01 conferred a potential 
      protective role for disease (P = 0.03, P(C)=0.13). Similar associations were 
      observed at haplotype level; DRB1*03~DQB1*02 (OR1.91,P = 0.01, P(C)=0.08), 
      DRB1*16~DQB1*05 (OR3.65,P = 0.004,P(C)=0.06) and DRB1*01~DQB1*05 
      (OR0.36,P = 0.04, P(C)=0.22). Remarkably, we observed significantly associations 
      of DRB1*03 with the appearance of anti-SSA/Ro (P(C)=0.02), anti-SSB/La 
      (P(C)=0.002) and anti-coagulant (P = 0.007), DRB1*15 with anti-SSA/Ro 
      (P(C)=0.04), DRB1*16 with anti-Sm (P(C)=0.02), DRB1*04 with anti-beta2gpI 
      (P(C)=3 * 10(-5)), anti-cardiolipin (P = 0.002) and rheumatoid factor (P = 0.004) 
      and DRB1*13 with anti-Sm (P(C)=0.02) and anti-beta2gpI (P(C)=0.01) antibodies. Also, 
      negative associations of DRB1*04 with anti-Sm, anti-SSA/Ro, DQB1*03 with anti-Sm 
      and DRB1*11 with anti-Sm and anti-beta2gpI were observed. CONCLUSIONS: We identified 
      DRB1*03 and DRB1*16 as risk alleles and DRB1*01 as a potential protective allele 
      for SLE disease. More importantly, we found a close link between genetic 
      susceptibility for SLE and autoantibodies status that was more evident for 
      DRB1*03 allele.
CI  - Copyright (c) 2021 European Federation of Immunological Societies. Published by 
      Elsevier B.V. All rights reserved.
FAU - Rasouli-Saravani, Ashkan
AU  - Rasouli-Saravani A
AD  - Department of Immunology, School of Medicine, Hamadan University of Medical 
      Sciences, Hamadan, Iran.
FAU - Tahamoli-Roudsari, Ahmad
AU  - Tahamoli-Roudsari A
AD  - Department of Internal Diseases Medicine, School of Medicine, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
FAU - Basiri, Zahra
AU  - Basiri Z
AD  - Department of Internal Diseases Medicine, School of Medicine, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
FAU - Babaei, Mahboobeh
AU  - Babaei M
AD  - Department of Internal Diseases Medicine, School of Medicine, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
FAU - Fazaeli, Alireza
AU  - Fazaeli A
AD  - Department of Internal Diseases Medicine, School of Medicine, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
FAU - Roshanaei, Ghodratollah
AU  - Roshanaei G
AD  - Department of Biostatistics and Epidemiology, School of Health, Hamadan 
      University of Medical Sciences, Hamadan, Iran.
FAU - Hajilooi, Mehrdad
AU  - Hajilooi M
AD  - Department of Immunology, School of Medicine, Hamadan University of Medical 
      Sciences, Hamadan, Iran.
FAU - Solgi, Ghasem
AU  - Solgi G
AD  - Department of Immunology, School of Medicine, Hamadan University of Medical 
      Sciences, Hamadan, Iran; d. Psoriasis Research Center, Department of Dermatology, 
      Farshchian Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.. 
      Electronic address: gh.solgi@umsha.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210626
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Antibodies, Antinuclear/immunology
MH  - Autoantibodies/*immunology
MH  - Autoantigens/immunology
MH  - Case-Control Studies
MH  - Female
MH  - *Genes, MHC Class II
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ beta-Chains/genetics/*immunology
MH  - HLA-DRB1 Chains/genetics/*immunology
MH  - Haplotypes/immunology
MH  - Humans
MH  - Iran
MH  - Lupus Erythematosus, Systemic/ethnology/genetics/*immunology
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Autoantibody
OT  - HLA-DQB1
OT  - HLA-DRB1
OT  - Systemic lupus erythematosus
EDAT- 2021/06/30 06:00
MHDA- 2022/01/29 06:00
CRDT- 2021/06/29 20:12
PHST- 2020/09/09 00:00 [received]
PHST- 2021/06/20 00:00 [revised]
PHST- 2021/06/22 00:00 [accepted]
PHST- 2021/06/30 06:00 [pubmed]
PHST- 2022/01/29 06:00 [medline]
PHST- 2021/06/29 20:12 [entrez]
AID - S0165-2478(21)00098-5 [pii]
AID - 10.1016/j.imlet.2021.06.004 [doi]
PST - ppublish
SO  - Immunol Lett. 2021 Sep;237:11-16. doi: 10.1016/j.imlet.2021.06.004. Epub 2021 Jun 
      26.