PMID- 34186304
OWN - NLM
STAT- MEDLINE
DCOM- 20210819
LR  - 20210819
IS  - 1873-4235 (Electronic)
IS  - 0956-5663 (Linking)
VI  - 191
DP  - 2021 Nov 1
TI  - High-efficiency charge transfer on SERS-active semiconducting K(2)Ti(6)O(13) 
      nanowires enables direct transition of photoinduced electrons to protein redox 
      centers.
PG  - 113452
LID - S0956-5663(21)00489-9 [pii]
LID - 10.1016/j.bios.2021.113452 [doi]
AB  - Photoinduced charge transfer (PICT) plays a crucial role in the chemical 
      mechanism of surface-enhanced Raman scattering (SERS), in which small organic 
      molecules are generally used as probes. Herein, semiconducting K(2)Ti(6)O(13) 
      nanowires (NWs) are synthesized and are found to exhibit high SERS activity 
      probed by 4-mercaptobenzoic acid (4-MBA). Density functional theory (DFT) 
      calculations reveal high-efficiency CT on the K(2)Ti(6)O(13) nanowires. 
      Furthermore, PICT on the K(2)Ti(6)O(13) NWs is for the first time evidenced by a 
      redox protein, cytochrome c (Cyt c). Under optimized experimental conditions, the 
      transformation of oxidized Cyt c to its reduced state clearly verifies the 
      electron transfer (ET) from the K(2)Ti(6)O(13) nanowire to the protein. The ET 
      mechanism is explored based on energy levels of semiconductors and molecular 
      dynamics simulations, thus revealing the importance of energy level matching and 
      electron tunneling from the semiconductor surface to the redox center. This study 
      indicates a great potential of multiple-layered K(2)Ti(6)O(13) NWs in the 
      application of SERS on semiconducting materials and more importantly, it provides 
      a new route for the rational design of protein-semiconductor interfaces for 
      investigating electron transfer processes of redox proteins and biocatalytic 
      reactions.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Chen, Lei
AU  - Chen L
AD  - Key Laboratory of Preparation and Applications of Environmental Friendly 
      Materials (Jilin Normal University), Ministry of Education, Changchun, 130103, 
      China.
FAU - Tang, Jinping
AU  - Tang J
AD  - State Key Laboratory of Supramolecular Structure and Materials, College of 
      Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
FAU - Ma, Hao
AU  - Ma H
AD  - State Key Laboratory of Supramolecular Structure and Materials, College of 
      Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
FAU - Jin, Sila
AU  - Jin S
AD  - Department of Chemistry, Institute for Molecular Science and Fusion Technology, 
      Kangwon National University, Chunchon, 24341, South Korea.
FAU - Xue, Xiangxin
AU  - Xue X
AD  - Key Laboratory of Preparation and Applications of Environmental Friendly 
      Materials (Jilin Normal University), Ministry of Education, Changchun, 130103, 
      China.
FAU - Han, Xiao Xia
AU  - Han XX
AD  - State Key Laboratory of Supramolecular Structure and Materials, College of 
      Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China. 
      Electronic address: hanxiaoxia@jlu.edu.cn.
FAU - Jung, Young Mee
AU  - Jung YM
AD  - Department of Chemistry, Institute for Molecular Science and Fusion Technology, 
      Kangwon National University, Chunchon, 24341, South Korea. Electronic address: 
      ymjung@kangwon.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20210619
PL  - England
TA  - Biosens Bioelectron
JT  - Biosensors & bioelectronics
JID - 9001289
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - *Biosensing Techniques
MH  - Electrons
MH  - *Nanowires
MH  - Oxidation-Reduction
MH  - Titanium
OTO - NOTNLM
OT  - Charge transfer
OT  - Cytochrome c
OT  - K(2)Ti(6)O(13) nanowires
OT  - SERS
OT  - Semiconductor
EDAT- 2021/06/30 06:00
MHDA- 2021/08/20 06:00
CRDT- 2021/06/29 20:18
PHST- 2021/06/04 00:00 [received]
PHST- 2021/06/16 00:00 [accepted]
PHST- 2021/06/30 06:00 [pubmed]
PHST- 2021/08/20 06:00 [medline]
PHST- 2021/06/29 20:18 [entrez]
AID - S0956-5663(21)00489-9 [pii]
AID - 10.1016/j.bios.2021.113452 [doi]
PST - ppublish
SO  - Biosens Bioelectron. 2021 Nov 1;191:113452. doi: 10.1016/j.bios.2021.113452. Epub 
      2021 Jun 19.