PMID- 34187117
OWN - NLM
STAT- MEDLINE
DCOM- 20211028
LR  - 20211028
IS  - 1553-3840 (Electronic)
IS  - 1553-3840 (Linking)
VI  - 18
IP  - 2
DP  - 2020 Dec 25
TI  - Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood 
      pressure, lipid profile, atherogenic index of plasma and some inflammatory and 
      antioxidant markers in type 2 diabetes mellitus patients: a clinical trial.
PG  - 405-411
LID - 10.1515/jcim-2020-0090 [doi]
AB  - BACKGROUND: In patients with type 2 diabetes mellitus (T2DM) the inflammatory and 
      metabolic responses to epigallocatechin-3-gallate (EGCG) are unknown. OBJECTIVES: 
      Evaluate the impacts of EGCG on metabolic factors and some biomarkers of stress 
      oxidative in patients with T2DM. METHODS: In this randomized, double-blind, 
      placebo-controlled trial, 50 patients with T2DM consumed either 2 tablets 
      (300 mg) EGCG (n=25) or wheat flour as placebo (n=25) for 2 months. The total 
      antioxidant capacity (TAC), interleukin-6 (IL-6), lipid profile, mean arterial 
      pressure (MAP), atherogenic index of plasma (AIP) were evaluated before and after 
      the intervention. RESULTS: The finding of present study exhibited a significant 
      increase in the serum levels of TAC after the EGCG supplementation (p=0.001). 
      Also, in compare with control group, the mean changes of TAC were significantly 
      higher in supplement group (p=0.01). In intervention group, a significant 
      decrease was observed in the mean levels of triglyceride, total cholesterol, 
      diastolic blood pressure (DBP), AIP, and MAP (p<0.05). Taking EGCG resulted in 
      the mean changes of total cholesterol, MAP and DBP were significantly lower in 
      compare with control group (p<0.05). CONCLUSIONS: This study recommended that 
      EGCG supplementation may be improved blood pressure, lipid profile, AIP, and 
      oxidative status in patients with T2DM.
CI  - (c) 2020 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Bazyar, Hadi
AU  - Bazyar H
AD  - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, 
      Ahvaz, Iran.
FAU - Hosseini, Seyed Ahmad
AU  - Hosseini SA
AD  - Nutrition and Metabolic Diseases Researcher Center, Ahvaz Jundishapur University 
      of Medical Sciences, Ahvaz, Iran.
FAU - Saradar, Sirous
AU  - Saradar S
AD  - Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
FAU - Mombaini, Delsa
AU  - Mombaini D
AD  - Nutrition and Metabolic Diseases Researcher Center, Ahvaz Jundishapur University 
      of Medical Sciences, Ahvaz, Iran.
FAU - Allivand, Mohammad
AU  - Allivand M
AD  - Nutrition and Metabolic Diseases Researcher Center, Ahvaz Jundishapur University 
      of Medical Sciences, Ahvaz, Iran.
FAU - Labibzadeh, Maryam
AU  - Labibzadeh M
AD  - Institute for Higher Education ACECR, Khouzestan, Iran.
FAU - Alipour, Meysam
AU  - Alipour M
AUID- ORCID: 0000-0003-3722-0528
AD  - Alimentary Tract Research Center, Ahvaz Jundishapur University of Medical 
      Sciences, Ahvaz, Iran.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20201225
PL  - Germany
TA  - J Complement Integr Med
JT  - Journal of complementary & integrative medicine
JID - 101313855
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Lipids)
RN  - 8R1V1STN48 (Catechin)
RN  - BQM438CTEL (epigallocatechin gallate)
SB  - IM
MH  - Antioxidants
MH  - Biomarkers
MH  - Blood Pressure
MH  - *Camellia sinensis
MH  - Catechin/analogs & derivatives
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Flour
MH  - Humans
MH  - Lipids
MH  - Plant Leaves
MH  - Triticum
OTO - NOTNLM
OT  - EGCG
OT  - inflammation
OT  - lipid profile
OT  - type 2 diabetes mellitus
EDAT- 2021/06/30 06:00
MHDA- 2021/10/29 06:00
CRDT- 2021/06/29 20:33
PHST- 2020/05/08 00:00 [received]
PHST- 2020/06/23 00:00 [accepted]
PHST- 2021/06/29 20:33 [entrez]
PHST- 2021/06/30 06:00 [pubmed]
PHST- 2021/10/29 06:00 [medline]
AID - jcim-2020-0090 [pii]
AID - 10.1515/jcim-2020-0090 [doi]
PST - epublish
SO  - J Complement Integr Med. 2020 Dec 25;18(2):405-411. doi: 10.1515/jcim-2020-0090.