PMID- 34187624
OWN - NLM
STAT- MEDLINE
DCOM- 20211222
LR  - 20211222
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 42
IP  - 4
DP  - 2021 Jul 1
TI  - Health-related quality of life in children with hereditary angioedema compared 
      with patients with histaminergic angioedema.
PG  - 325-332
LID - 10.2500/aap.2021.42.210019 [doi]
AB  - Background: Hereditary angioedema (HAE) is a potentially life-threatening disease 
      that remarkably impacts patients' health-related quality of life (HRQoL). This 
      study evaluated the HRQoL in children with HAE and compared it with healthy 
      controls and patients with histaminergic angioedema (HA). Methods: Fifty-nine 
      children with HAE (median [interquartile range IQR], ages, 8.9 years [5.4-12.6 
      years]), 60 children with HA (median [IQR] ages, 10.3 years [8-15.4 years]), and 
      72 healthy controls (median [IQR] ages, 10.3 years [6.6-13.9 years]) were 
      recruited. All the children and their families completed the age-adapted KINDL 
      generic instrument for assessing health-related quality of life in children and 
      adolescents. Results: The total HRQoL score and other subscales scores of both 
      the patients with HAE and patients with HA, and the parent-proxy reports were 
      significantly lower than those of the healthy children (p < 0.05). In the 
      patients with HAE, the age at symptom onset was positively correlated with 
      physical well-being (r = 0.335; p = 0.043) and negatively correlated with 
      self-esteem (r = -0.324; p = 0.049). In addition, the physical well-being scores 
      were affected by the site of attacks, which was significantly lower in the 
      patients with abdominal pain attacks (p = 0.045). The family scores and total 
      scores were statistically significantly higher in the HA group than the HAE group 
      (p < 0.001 and p = 0.009, respectively). A significant correlation was found 
      between self-report and parent-proxy HRQoLs in total and all subscales scores in 
      the patients with HAE. For HA, there were no significant correlations for family 
      scores. Conclusion: HAE caused significant impairment of the HRQoL of children 
      and their families, and affected their lifestyle and quality of life. In 
      pediatric patients with HAE, the HRQoL is mainly related to age at symptom onset 
      and the site of attacks. Although patients with HAE are affected more negatively 
      than the patients with HA, HA affected the quality of life as well.
FAU - Ocak, Melike
AU  - Ocak M
AD  - From the Department of Pediatric Allergy, Hacettepe University Faculty of 
      Medicine, Ankara, Turkey; and.
FAU - Nain, Ercan
AU  - Nain E
AD  - Department of Pediatric Allergy, Sanliurfa Training and Research Hospital, 
      Sanliurfa, Turkey.
FAU - Akarsu, Aysegul
AU  - Akarsu A
AD  - From the Department of Pediatric Allergy, Hacettepe University Faculty of 
      Medicine, Ankara, Turkey; and.
FAU - Sahiner, Umit Murat
AU  - Sahiner UM
AD  - From the Department of Pediatric Allergy, Hacettepe University Faculty of 
      Medicine, Ankara, Turkey; and.
FAU - Sekerel, Bulent Enis
AU  - Sekerel BE
AD  - From the Department of Pediatric Allergy, Hacettepe University Faculty of 
      Medicine, Ankara, Turkey; and.
FAU - Soyer, Ozge
AU  - Soyer O
AD  - From the Department of Pediatric Allergy, Hacettepe University Faculty of 
      Medicine, Ankara, Turkey; and.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Complement C1 Inhibitor Protein)
SB  - IM
MH  - Adolescent
MH  - Angioedema
MH  - *Angioedemas, Hereditary/diagnosis/epidemiology
MH  - Child
MH  - Complement C1 Inhibitor Protein
MH  - Humans
MH  - Parents
MH  - Quality of Life
MH  - Self Report
EDAT- 2021/07/01 06:00
MHDA- 2021/12/24 06:00
CRDT- 2021/06/30 05:45
PHST- 2021/06/30 05:45 [entrez]
PHST- 2021/07/01 06:00 [pubmed]
PHST- 2021/12/24 06:00 [medline]
AID - 10.2500/aap.2021.42.210019 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2021 Jul 1;42(4):325-332. doi: 10.2500/aap.2021.42.210019.