PMID- 34188977 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210701 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 13 IP - 5 DP - 2021 May 25 TI - Methylenedioxymethamphetamine (MDMA)-Induced Hyponatremia: Case Report and Literature Review. PG - e15223 LID - 10.7759/cureus.15223 [doi] LID - e15223 AB - 3,4-Methylenedioxymethamphetamine, MDMA, or "ecstasy", is a trending recreational drug used by the young crowd for obtaining "euphoria." Over the past few years, there have been multiple reports of teenagers committing suicide and suddenly dying post ingesting MDMA. Compared to other illicit drugs such as heroin, hash and cocaine, ecstasy is relatively new hence the popularity. There are multiple toxicities associated with MDMA, including but not limited to seizures, depression, liver failure, or thrombosis. However, in this report, we will focus on hyponatremia and one of the most feared complications of such electrolyte disturbance: seizures. The rapid reversal of the hyponatremia with hypertonic saline in such acute setting is key to reduce risk of cerebral swelling. We report a case of a young female with no past medical history who presented to emergency department post ecstasy use with tonic-clonic seizure and hyponatremia. CI - Copyright (c) 2021, Elkattawy et al. FAU - Elkattawy, Sherif AU - Elkattawy S AD - Internal Medicine, Rutgers New Jersey Medical School/Trinitas Regional Medical Center, Elizabeth, USA. FAU - Mowafy, Ahmed AU - Mowafy A AD - Internal Medicine, Rutgers New Jersey Medical School/Trinitas Regional Medical Center, Elizabeth, USA. FAU - Younes, Islam AU - Younes I AD - Internal Medicine, Rutgers New Jersey Medical School/Trinitas Regional Medical Center, Elizabeth, USA. FAU - Tucktuck, Marina AU - Tucktuck M AD - Internal Medicine, St. George's University School of Medicine, True Blue, GRD. FAU - Agresti, James AU - Agresti J AD - Nephrology, Trinitas Regional Medical Center, Elizabeth, USA. LA - eng PT - Case Reports DEP - 20210525 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC8232921 OTO - NOTNLM OT - ecstasy OT - hyponatremia OT - mdma OT - methylenedioxymethamphetamine OT - recreational drug COIS- The authors have declared that no competing interests exist. EDAT- 2021/07/01 06:00 MHDA- 2021/07/01 06:01 PMCR- 2021/05/25 CRDT- 2021/06/30 06:41 PHST- 2021/06/30 06:41 [entrez] PHST- 2021/07/01 06:00 [pubmed] PHST- 2021/07/01 06:01 [medline] PHST- 2021/05/25 00:00 [pmc-release] AID - 10.7759/cureus.15223 [doi] PST - epublish SO - Cureus. 2021 May 25;13(5):e15223. doi: 10.7759/cureus.15223.