PMID- 34189286
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220424
IS  - 2405-6502 (Electronic)
IS  - 2405-6502 (Linking)
VI  - 24
DP  - 2021 Sep
TI  - Lifetime prevalence of epilepsy in urban Tanzania - A door-to-door random cluster 
      survey.
PG  - 100352
LID - 10.1016/j.ensci.2021.100352 [doi]
LID - 100352
AB  - OBJECTIVES: Epileptic seizures and epilepsy in urban settings of low-income and 
      middle-income countries (LMIC) are largely under-researched, but their prevalence 
      is necessary for good healthcare planning. This study aimed to determine the 
      lifetime prevalence of epileptic seizures and epilepsy in urban Dar es Salaam. 
      METHODS: Nearly 50,000 people in former Kinondoni district, Dar es Salaam, were 
      screened for epileptic seizures using a set of nine questions. Answers to these 
      nine questions were categorized into generalized, focal, and unspecified 
      seizures. Screening positivity rates were adjusted for questionnaire inaccuracy 
      using two scenarios to analyse true epilepsy prevalences. RESULTS: Overall, 1085 
      (2.23%) people fulfilled the criteria for ever having had at least one type of 
      epileptic seizure. Two-hundred-ninety-six (0.60%) people screened positive for 
      generalized seizures, 986 (2.02%) for focal seizures, and 32 (0.07%) for 
      unspecified seizures. Women more commonly screened positive than men (2.61% 
      versus 1.72%, p < 0.001), particularly for focal seizures (p < 0.001). Adjusting 
      for different degrees of accuracy of the screening questionnaire yielded true 
      lifetime prevalences for epilepsy of any type between 1.59% and 2.41%. We 
      furthermore observed a considerable variation of screening positivity rates 
      between wards in Kinondoni district (p < 0.001). CONCLUSION: The prevalence of 
      epilepsy, based on a questionnaire survey in urban Tanzania, was higher than 
      previously observed, probably due to the screening questionnaire, which contained 
      questions specifically designed to identify focal seizures. Further studies on 
      epileptic seizures/epilepsy are needed for urban settings in LMIC, preferably 
      with an integrated follow-up of positive cases.
CI  - (c) 2021 The Authors. Published by Elsevier B.V.
FAU - Stelzle, Dominik
AU  - Stelzle D
AD  - Center for Global Health, Department of Neurology, School of Medicine, Technical 
      University of Munich, Germany.
AD  - Chair of Epidemiology, Department of Sport and Health Sciences, Technical 
      University of Munich, Germany.
FAU - Schmidt, Veronika
AU  - Schmidt V
AD  - Center for Global Health, Department of Neurology, School of Medicine, Technical 
      University of Munich, Germany.
AD  - Centre for Global Health, Institute of Health and Society, University of Oslo, 
      Norway.
FAU - Ngowi, Bernard J
AU  - Ngowi BJ
AD  - National Institute for Medical Research, Dar es Salaam, Tanzania.
FAU - Matuja, William
AU  - Matuja W
AD  - Department of Neurology, Muhimbili University of Health and Allied Sciences, Dar 
      es Salaam, Tanzania.
FAU - Schmutzhard, Erich
AU  - Schmutzhard E
AD  - Department of Neurology, Medical University of Innsbruck, Austria.
FAU - Winkler, Andrea S
AU  - Winkler AS
AD  - Center for Global Health, Department of Neurology, School of Medicine, Technical 
      University of Munich, Germany.
AD  - Centre for Global Health, Institute of Health and Society, University of Oslo, 
      Norway.
LA  - eng
PT  - Journal Article
DEP - 20210615
PL  - Netherlands
TA  - eNeurologicalSci
JT  - eNeurologicalSci
JID - 101667077
PMC - PMC8220170
OTO - NOTNLM
OT  - Census
OT  - Epidemiology
OT  - Epilepsy
OT  - Global health
OT  - Seizures
EDAT- 2021/07/01 06:00
MHDA- 2021/07/01 06:01
PMCR- 2021/06/15
CRDT- 2021/06/30 06:45
PHST- 2021/04/13 00:00 [received]
PHST- 2021/06/02 00:00 [revised]
PHST- 2021/06/13 00:00 [accepted]
PHST- 2021/06/30 06:45 [entrez]
PHST- 2021/07/01 06:00 [pubmed]
PHST- 2021/07/01 06:01 [medline]
PHST- 2021/06/15 00:00 [pmc-release]
AID - S2405-6502(21)00044-7 [pii]
AID - 100352 [pii]
AID - 10.1016/j.ensci.2021.100352 [doi]
PST - epublish
SO  - eNeurologicalSci. 2021 Jun 15;24:100352. doi: 10.1016/j.ensci.2021.100352. 
      eCollection 2021 Sep.