PMID- 34189833
OWN - NLM
STAT- MEDLINE
DCOM- 20210819
LR  - 20210929
IS  - 1473-2165 (Electronic)
IS  - 1473-2130 (Print)
IS  - 1473-2130 (Linking)
VI  - 20
IP  - 9
DP  - 2021 Sep
TI  - A pilot study evaluating the efficacy and tolerability of a comprehensive, 
      hydrating topical antioxidant developed specifically for men.
PG  - 2816-2823
LID - 10.1111/jocd.14314 [doi]
AB  - INTRODUCTION: There is growing interest in skincare products designed for men. 
      This pilot study evaluated the efficacy and tolerability of a comprehensive 
      antioxidant product in men. METHODS: This 12-week study evaluated improvements 
      from baseline in erythema, lines/wrinkles, skin tone, texture, brightness, 
      dryness/flaking and pores (6-point scale), global improvements (5-point scale), 
      and sebum levels following daily application in males with mild to moderate 
      photodamaged skin. Subject self-assessments and adverse events (AEs) were 
      captured. RESULTS: Twenty-two subjects completed the study. Early mean percent 
      improvements from baseline were demonstrated in all categories at week 4 with 
      visible improvements in skin tone (29%; p = .0001) and pores (28%; p < .0001). 
      Reductions in skin surface sebum levels (forehead region) from baseline were 
      demonstrated at 8 (p < .0001) and 12 (p < .0003) weeks. Ninety-six percent of 
      subjects reported overall visible improvement of their skin and that the study 
      product calmed/soothed skin, reducing redness and irritation after shaving. One 
      subject reported mild dryness. CONCLUSION: Once daily application of a 
      comprehensive topical antioxidant designed for men led to significant 
      improvements in skin appearance, substantial reductions in skin surface sebum 
      levels, and was well tolerated with a high level of subject satisfaction over 
      12 weeks.
CI  - (c) 2021 Skinbetter science, LLC/ Derma Forece. Journal of Cosmetic Dermatology 
      published by Wiley Periodicals LLC.
FAU - Sikora, Brooke C
AU  - Sikora BC
AD  - SkinCare Physicians, Chestnut Hill, MA, USA.
FAU - Wortzman, Mitchell
AU  - Wortzman M
AD  - skinbetter science, LLC, Phoenix, AZ, USA.
FAU - Nelson, Diane B
AU  - Nelson DB
AUID- ORCID: 0000-0002-5584-1574
AD  - skinbetter science, LLC, Phoenix, AZ, USA.
FAU - Dover, Jeffrey S
AU  - Dover JS
AD  - SkinCare Physicians, Chestnut Hill, MA, USA.
LA  - eng
GR  - skinbetter science, LLC/
PT  - Journal Article
DEP - 20210803
PL  - England
TA  - J Cosmet Dermatol
JT  - Journal of cosmetic dermatology
JID - 101130964
RN  - 0 (Antioxidants)
SB  - IM
MH  - *Antioxidants/adverse effects
MH  - Humans
MH  - Male
MH  - Pilot Projects
MH  - *Skin Aging
MH  - Skin Cream
MH  - Treatment Outcome
PMC - PMC8457217
OTO - NOTNLM
OT  - antioxidants
OT  - hydration
OT  - male skin
OT  - pores
OT  - sebum reduction
OT  - skincare
EDAT- 2021/07/01 06:00
MHDA- 2021/08/20 06:00
PMCR- 2021/09/22
CRDT- 2021/06/30 07:04
PHST- 2021/04/30 00:00 [revised]
PHST- 2021/03/11 00:00 [received]
PHST- 2021/06/07 00:00 [accepted]
PHST- 2021/07/01 06:00 [pubmed]
PHST- 2021/08/20 06:00 [medline]
PHST- 2021/06/30 07:04 [entrez]
PHST- 2021/09/22 00:00 [pmc-release]
AID - JOCD14314 [pii]
AID - 10.1111/jocd.14314 [doi]
PST - ppublish
SO  - J Cosmet Dermatol. 2021 Sep;20(9):2816-2823. doi: 10.1111/jocd.14314. Epub 2021 
      Aug 3.