PMID- 34190665
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20220531
IS  - 1466-1799 (Electronic)
IS  - 0007-1668 (Linking)
VI  - 63
IP  - 2
DP  - 2022 Apr
TI  - Dietary calcium levels regulate calcium transporter gene expression levels in the 
      small intestine of broiler chickens.
PG  - 202-210
LID - 10.1080/00071668.2021.1949697 [doi]
AB  - 1. This study investigated the effect of dietary calcium (Ca) levels on growth 
      performance, bone development and Ca transporter gene expression levels in the 
      small intestine of broiler chickens.2. On the day of hatch, 350, Ross 308 male 
      broilers were randomly allotted to one of five treatments with five replicate 
      pens each and 14 birds per pen. Dietary Ca levels in feed were 5.0, 7.0, 9.0, 
      11.0 and 13.0 g/kg, in which 9.0 g/kg was in the control diet. All diets 
      contained 4.5 g/kg non-phytate phosphorus (NPP).3. The increase in dietary Ca 
      levels from 5.0 to 13.0 g/kg did not affect the growth performance of 1- to 
      18-day-old broilers (P > 0.05).4. Increasing the Ca levels linearly increased the 
      ash weight and the contents of ash, Ca and phosphorus (P) in the tibia of 
      broilers at 18 days of age (P < 0.05). The contents of ash, Ca and P in broilers 
      fed with 9.0 g/kg Ca were higher than those in birds fed with 5.0 g/kg Ca 
      (P < 0.05).5. Increasing the Ca levels linearly decreased mRNA expression levels 
      of the Ca-binding protein 28-kDa (CaBP-D28k), plasma membrane Ca-transporting 
      ATPase 1b (PMCAlb), sodium (Na)/Ca exchanger 1 (NCX1), nuclear vitamin D receptor 
      (nVDR) and membrane vitamin D receptor (mVDR) in the duodenum of broilers at 18 d 
      of age (P < 0.05). Similar results were seen in the jejunum and ileum. Broilers 
      fed 9.0-13.0 g/kg Ca in feed had lower mRNA expression levels of CaBP-D28k and 
      PMCAlb in the small intestine than birds fed 5.0 g/kg Ca in feed (P < 0.05).6. 
      The data indicated that low levels of dietary Ca stimulated its transporter gene 
      transcription and promoted absorption, but high levels of Ca inhibited 
      transporter gene expression and prevented excessive absorption in the small 
      intestine of broiler chickens.
FAU - Han, J C
AU  - Han JC
AD  - Department of Animal Science, College of Life Science, Shangqiu Normal 
      University, Shangqiu, China.
FAU - Wang, X N
AU  - Wang XN
AD  - Department of Animal Science, College of Life Science, Shangqiu Normal 
      University, Shangqiu, China.
AD  - College of Animal Science and Technology, Henan Agricultural University, 
      Zhengzhou, China.
FAU - Wu, L H
AU  - Wu LH
AD  - Department of Animal Science, College of Life Science, Shangqiu Normal 
      University, Shangqiu, China.
AD  - College of Animal Science and Technology, Henan Agricultural University, 
      Zhengzhou, China.
FAU - Lv, X L
AU  - Lv XL
AD  - Department of Animal Science, College of Life Science, Shangqiu Normal 
      University, Shangqiu, China.
AD  - College of Animal Science and Technology, Henan Agricultural University, 
      Zhengzhou, China.
FAU - He, L
AU  - He L
AD  - Department of Animal Science, College of Life Science, Shangqiu Normal 
      University, Shangqiu, China.
AD  - College of Life Sciences, Henan Normal University, Xinxiang, China.
FAU - Qu, H X
AU  - Qu HX
AD  - Department of Animal Science, College of Life Science, Shangqiu Normal 
      University, Shangqiu, China.
FAU - Shi, C X
AU  - Shi CX
AD  - Department of Animal Science, College of Life Science, Shangqiu Normal 
      University, Shangqiu, China.
FAU - Zhang, L
AU  - Zhang L
AD  - Department of Animal Science, College of Life Science, Shangqiu Normal 
      University, Shangqiu, China.
FAU - Wang, Z X
AU  - Wang ZX
AD  - College of Animal Science and Technology, Henan Agricultural University, 
      Zhengzhou, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial, Veterinary
DEP - 20210809
PL  - England
TA  - Br Poult Sci
JT  - British poultry science
JID - 15740290R
RN  - 0 (Calcium, Dietary)
RN  - 0 (Phosphorus, Dietary)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animal Feed/analysis
MH  - Animals
MH  - Calcium/metabolism
MH  - Calcium, Dietary/metabolism
MH  - *Chickens/physiology
MH  - Diet/veterinary
MH  - Dietary Supplements
MH  - Gene Expression
MH  - Intestine, Small
MH  - Male
MH  - *Phosphorus, Dietary/metabolism
OTO - NOTNLM
OT  - CaBP-D28k
OT  - Growth
OT  - NCX1
OT  - PMCAlb
OT  - VDR
OT  - bone
EDAT- 2021/07/01 06:00
MHDA- 2022/03/19 06:00
CRDT- 2021/06/30 12:18
PHST- 2021/07/01 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2021/06/30 12:18 [entrez]
AID - 10.1080/00071668.2021.1949697 [doi]
PST - ppublish
SO  - Br Poult Sci. 2022 Apr;63(2):202-210. doi: 10.1080/00071668.2021.1949697. Epub 
      2021 Aug 9.