PMID- 34191174
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210702
IS  - 2510-3636 (Electronic)
IS  - 2510-3636 (Linking)
VI  - 3
IP  - 1
DP  - 2019 Feb 15
TI  - Assessment of the kidney function parameters split function, mean transit time, 
      and outflow efficiency using dynamic FDG-PET/MRI in healthy subjects.
PG  - 3
LID - 10.1186/s41824-019-0051-9 [doi]
LID - 3
AB  - BACKGROUND: Traditionally, isotope nephrography is considered as the method of 
      choice to assess kidney function parameters in nuclear medicine. We propose a 
      novel approach to determine the split function (SF), mean transit time (MTT), and 
      outflow efficiency (OE) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) dynamic 
      positron emission tomography (PET). MATERIALS AND METHODS: Healthy adult subjects 
      underwent dynamic simultaneous FDG-PET and magnetic resonance imaging (PET/MRI). 
      Time-activity curves (TACs) of total kidneys, renal cortices, and the aorta were 
      prospectively obtained from dynamic PET series. MRI images were used for 
      anatomical correlation. The same individuals were subjected to dynamic renal 
      Technetium-99 m-mercaptoacetyltriglycine (MAG3) scintigraphy and TACs of kidneys; 
      the perirenal background and the left ventricle were determined. SF was 
      calculated on the basis of integrals over the TACs, MTT was determined from renal 
      retention functions after deconvolution analysis, and OE was determined from MTT. 
      Values obtained from PET series were compared with scintigraphic parameters, 
      which served as the reference. RESULTS: Twenty-four subjects underwent both 
      examinations. Total kidney SF, MTT, and OE as estimated by dynamic PET/MRI 
      correlated to their reference values by r = 0.75, r = 0.74 and r = 0.81, 
      respectively, with significant difference (p < 0.0001) between the means of MTT 
      and OE. No correlations were found for cortex FDG values. CONCLUSIONS: The study 
      proofs the concept that SF, MTT, and OE can be estimated with dynamic FDG PET/MRI 
      scans in healthy kidneys. This has advantages for patients receiving a routine 
      PET/MRI scan, as kidney parameters can be estimated simultaneously to functional 
      and morphological imaging with high accuracy.
FAU - Geist, Barbara K
AU  - Geist BK
AD  - Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear 
      Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, 
      Austria.
FAU - Baltzer, Pascal
AU  - Baltzer P
AD  - Department of Biomedical Imaging and Image-guided Therapy, Division of General 
      and Pediatric Radiology, Medical University of Vienna, Vienna, Austria.
FAU - Fueger, Barbara
AU  - Fueger B
AD  - Department of Biomedical Imaging and Image-guided Therapy, Division of General 
      and Pediatric Radiology, Medical University of Vienna, Vienna, Austria.
FAU - Hamboeck, Martina
AU  - Hamboeck M
AD  - Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear 
      Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, 
      Austria.
FAU - Nakuz, Thomas
AU  - Nakuz T
AD  - Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear 
      Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, 
      Austria.
FAU - Papp, Laszlo
AU  - Papp L
AD  - Center for Medical Physics and Biomedical Engineering, Medical University of 
      Vienna, Vienna, Austria.
FAU - Rasul, Sazan
AU  - Rasul S
AD  - Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear 
      Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, 
      Austria.
FAU - Sundar, Lalith Kumar Shiyam
AU  - Sundar LKS
AD  - Center for Medical Physics and Biomedical Engineering, Medical University of 
      Vienna, Vienna, Austria.
FAU - Hacker, Marcus
AU  - Hacker M
AUID- ORCID: 0000-0002-4222-4083
AD  - Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear 
      Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, 
      Austria. marcus.hacker@meduniwien.ac.at.
FAU - Staudenherz, Anton
AU  - Staudenherz A
AD  - Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear 
      Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, 
      Austria.
LA  - eng
PT  - Journal Article
DEP - 20190215
PL  - England
TA  - Eur J Hybrid Imaging
JT  - European journal of hybrid imaging
JID - 101724113
PMC - PMC8212313
OTO - NOTNLM
OT  - FDG
OT  - PET/MRI
OT  - Renal mean transit time
OT  - Renal outflow efficiency
OT  - Renal split function
COIS- The authors declare that they have no competing interests.
EDAT- 2019/02/15 00:00
MHDA- 2019/02/15 00:01
PMCR- 2019/02/15
CRDT- 2021/06/30 12:34
PHST- 2018/11/30 00:00 [received]
PHST- 2019/01/17 00:00 [accepted]
PHST- 2021/06/30 12:34 [entrez]
PHST- 2019/02/15 00:00 [pubmed]
PHST- 2019/02/15 00:01 [medline]
PHST- 2019/02/15 00:00 [pmc-release]
AID - 10.1186/s41824-019-0051-9 [pii]
AID - 51 [pii]
AID - 10.1186/s41824-019-0051-9 [doi]
PST - epublish
SO  - Eur J Hybrid Imaging. 2019 Feb 15;3(1):3. doi: 10.1186/s41824-019-0051-9.