PMID- 34192979
OWN - NLM
STAT- MEDLINE
DCOM- 20220923
LR  - 20220923
IS  - 2038-2529 (Electronic)
IS  - 0300-8916 (Linking)
VI  - 108
IP  - 5
DP  - 2022 Oct
TI  - Occult lymph node metastasis in patients with laryngeal cancer and relevant 
      predicting factors: a single-center experience.
PG  - 439-449
LID - 10.1177/03008916211026977 [doi]
AB  - OBJECTIVE: To reveal the incidence and predictive parameters of occult cervical 
      lymph node metastasis (LNM) in patients with cN0 laryngeal squamous cell cancer 
      (LSCC) who underwent surgery as definitive treatment. METHODS: Patients with cN0 
      laryngeal cancer who had undergone elective neck dissection together with partial 
      or total laryngectomy between January 2006 and November 2020 were retrospectively 
      analyzed. Clinical and histopathologic predictors of occult metastasis were also 
      analyzed. Follow-up data were used to obtain recurrence and survival analysis. 
      RESULTS: A total of 86 patients with a mean age of 62.5 years were included in 
      the study. Occult LNM was detected in 15 (17.4%) patients. Tumor grade, pT stage, 
      thyroid cartilage invasion, and extralaryngeal extension were found to predict 
      occult neck metastasis in univariate analysis. The mean follow-up time was 60.7 
      months and in the survival/recurrence analysis, pT stage, tumor location, tumor 
      grade, presence of occult metastasis, pre-epiglottic space involvement. and 
      extralaryngeal extension were found to predict poorer outcome. CONCLUSION: 
      Overall occult LNM is low (17.4%) in N0 laryngeal cancer, but the presence of LNM 
      is a poor prognostic factor. Correct determination of the neck status and proper 
      treatment is crucial. The incidence of LNM is very low in T1-T2 stages and 
      well-differentiated tumors. The "wait and see" strategy may be applied in T1-T2 
      cases as well as selected T3 cases with well-differentiated tumors.
FAU - Bayir, Omer
AU  - Bayir O
AD  - Department of Otolaryngology, Head and Neck Surgery, University of Health 
      Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, 
      Turkey.
FAU - Toptas, Gokhan
AU  - Toptas G
AUID- ORCID: 0000-0003-2444-4450
AD  - Department of Otolaryngology, Head and Neck Surgery, University of Health 
      Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, 
      Turkey.
FAU - Saylam, Guleser
AU  - Saylam G
AD  - Department of Otolaryngology, Head and Neck Surgery, University of Health 
      Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, 
      Turkey.
FAU - Izgi, Turan Canmurat
AU  - Izgi TC
AD  - Department of Otolaryngology, Head and Neck Surgery, University of Health 
      Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, 
      Turkey.
FAU - Han, Unsal
AU  - Han U
AD  - Department of Pathology, University of Health Sciences, Diskapi Yildirim Beyazit 
      Training and Research Hospital, Ankara, Turkey.
FAU - Keseroglu, Kemal
AU  - Keseroglu K
AD  - Department of Otolaryngology, Head and Neck Surgery, University of Health 
      Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, 
      Turkey.
FAU - Akyildiz, Ilker
AU  - Akyildiz I
AD  - Department of Otolaryngology, Head and Neck Surgery, University of Health 
      Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, 
      Turkey.
FAU - Korkmaz, Mehmet Hakan
AU  - Korkmaz MH
AD  - Department of Otolaryngology, Head and Neck Surgery, University of Health 
      Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, 
      Turkey.
AD  - Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Ankara 
      Yildirim Beyazit University, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210630
PL  - United States
TA  - Tumori
JT  - Tumori
JID - 0111356
SB  - IM
MH  - Humans
MH  - *Laryngeal Neoplasms/pathology/surgery
MH  - Lymph Nodes/pathology/surgery
MH  - Lymphatic Metastasis/pathology
MH  - Middle Aged
MH  - Neck Dissection
MH  - Neoplasm Staging
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Squamous cell carcinoma
OT  - larynx
OT  - lymph node
OT  - neck dissection
OT  - occult lymph node metastasis
EDAT- 2021/07/02 06:00
MHDA- 2022/09/24 06:00
CRDT- 2021/07/01 05:37
PHST- 2021/07/02 06:00 [pubmed]
PHST- 2022/09/24 06:00 [medline]
PHST- 2021/07/01 05:37 [entrez]
AID - 10.1177/03008916211026977 [doi]
PST - ppublish
SO  - Tumori. 2022 Oct;108(5):439-449. doi: 10.1177/03008916211026977. Epub 2021 Jun 
      30.