PMID- 34193265
OWN - NLM
STAT- MEDLINE
DCOM- 20210702
LR  - 20210708
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 14
IP  - 1
DP  - 2021 Jun 30
TI  - Latent tuberculosis infection among patients with and without type-2 diabetes 
      mellitus: results from a hospital case-control study in Atlanta.
PG  - 252
LID - 10.1186/s13104-021-05662-0 [doi]
LID - 252
AB  - OBJECTIVE: The purpose of this study is to compare the prevalence of latent TB 
      infection (LTBI) among patients with type-2 diabetes mellitus (T2DM) to healthy 
      controls without T2DM. To achieve this objective, we conducted a case-control 
      study in a large hospital in Atlanta from 2016 to 2019. RESULTS: We enrolled 98 
      cases; 119 potential controls were screened, 84 of which had HbA1c  >/=  5.7% and 
      one did not have QFT result, leaving 34 (28.6%) individuals enrolled as controls. 
      LTBI prevalence was 9.2% among cases and 14.7% among controls (crude odds ratio 
      0.59, 95% CI 0.19-2.04). After adjusting for age and sex, the adjusted odds of 
      LTBI among patients with T2DM was 0.45 (95% CI 0.13, 1.71) times the controls. We 
      did not observe a statistically significant association between LTBI and T2DM. 
      However, we reported a positive correlation between HbA1c level and nil count 
      among individuals with LTBI (R(2)  =  0.55, p  <  0.01). In addition, we reported 
      a high prevalence of LTBI among adults with T2DM and family members without T2DM.
FAU - Salindri, Argita D
AU  - Salindri AD
AUID- ORCID: 0000-0003-0962-0348
AD  - Division of Epidemiology and Biostatistics, Department of Population Health 
      Sciences, School of Public Health, Georgia State University, Atlanta, GA, 30303, 
      USA. asalindri1@student.gsu.edu.
FAU - Haw, J Sonya
AU  - Haw JS
AD  - Division of Endocrinology, Metabolism and Lipids, Emory University School of 
      Medicine, Atlanta, GA, USA.
FAU - Amere, Genet A
AU  - Amere GA
AD  - Division of Epidemiology and Biostatistics, Department of Population Health 
      Sciences, School of Public Health, Georgia State University, Atlanta, GA, 30303, 
      USA.
FAU - Alese, Joyce T
AU  - Alese JT
AD  - Division of Epidemiology and Biostatistics, Department of Population Health 
      Sciences, School of Public Health, Georgia State University, Atlanta, GA, 30303, 
      USA.
FAU - Umpierrez, Guillermo E
AU  - Umpierrez GE
AD  - Division of Endocrinology, Metabolism and Lipids, Emory University School of 
      Medicine, Atlanta, GA, USA.
FAU - Magee, Matthew J
AU  - Magee MJ
AD  - Division of Epidemiology and Biostatistics, Department of Population Health 
      Sciences, School of Public Health, Georgia State University, Atlanta, GA, 30303, 
      USA.
AD  - Hubert Department of Global Health, Rollins School of Public Health, Emory 
      University, Atlanta, GA, USA.
LA  - eng
GR  - UL1 TR000454/TR/NCATS NIH HHS/United States
GR  - UL1TR000454/TR/NCATS NIH HHS/United States
GR  - R03AI35388/National Institute of Allergy and Infectious Diseases/
PT  - Journal Article
DEP - 20210630
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Hospitals
MH  - Humans
MH  - *Latent Tuberculosis/complications/epidemiology
MH  - Prevalence
MH  - Risk Factors
MH  - Tuberculin Test
PMC - PMC8247096
OTO - NOTNLM
OT  - Latent TB infection
OT  - Tuberculosis
OT  - Type-2 diabetes
COIS- We have no competing interests to declare.
EDAT- 2021/07/02 06:00
MHDA- 2021/07/03 06:00
PMCR- 2021/06/30
CRDT- 2021/07/01 05:52
PHST- 2021/02/22 00:00 [received]
PHST- 2021/06/17 00:00 [accepted]
PHST- 2021/07/01 05:52 [entrez]
PHST- 2021/07/02 06:00 [pubmed]
PHST- 2021/07/03 06:00 [medline]
PHST- 2021/06/30 00:00 [pmc-release]
AID - 10.1186/s13104-021-05662-0 [pii]
AID - 5662 [pii]
AID - 10.1186/s13104-021-05662-0 [doi]
PST - epublish
SO  - BMC Res Notes. 2021 Jun 30;14(1):252. doi: 10.1186/s13104-021-05662-0.