PMID- 34193719
OWN - NLM
STAT- MEDLINE
DCOM- 20210819
LR  - 20210819
IS  - 1347-5223 (Electronic)
IS  - 0009-2363 (Linking)
VI  - 69
IP  - 7
DP  - 2021
TI  - Pyrrolactams from Marine Sponge Stylissa massa Collected from Myanmar and Their 
      Anti-Vpr Activities.
PG  - 702-705
LID - 10.1248/cpb.c21-00227 [doi]
AB  - A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 
      2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated 
      from the EtOAc extract of marine sponge Stylissa massa collected in Myanmar. The 
      absolute configuration at C-10 of 1 was determined as R by the electronic 
      circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine 
      showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an 
      effective dose of 10 microM and its potency was comparable to that of positive 
      control damnacanthal.
FAU - Win, Nwet Nwet
AU  - Win NN
AD  - Institute of Natural Medicine, University of Toyama.
FAU - Kodama, Takeshi
AU  - Kodama T
AD  - Institute of Natural Medicine, University of Toyama.
FAU - Aye, Aung Aung
AU  - Aye AA
AD  - Department of Marine Sciences, Myeik University.
FAU - Lae, Khine Zar Wynn
AU  - Lae KZW
AD  - Department of Chemistry, University of Yangon.
FAU - Ngwe, Hla
AU  - Ngwe H
AD  - Department of Chemistry, University of Yangon.
FAU - Han, Nang Mya
AU  - Han NM
AD  - Department of Marine Sciences, Myeik University.
FAU - Abe, Ikuro
AU  - Abe I
AD  - Graduate School of Pharmaceutical Sciences, The University of Tokyo.
AD  - Collaborative Research Institute for Innovative Microbiology, The University of 
      Tokyo.
FAU - Morita, Hiroyuki
AU  - Morita H
AD  - Institute of Natural Medicine, University of Toyama.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Chem Pharm Bull (Tokyo)
JT  - Chemical & pharmaceutical bulletin
JID - 0377775
RN  - 0 (Alkaloids)
RN  - 0 (Antiviral Agents)
RN  - 0 (vpr Gene Products, Human Immunodeficiency Virus)
RN  - 0 (vpr protein, Human immunodeficiency virus 1)
SB  - IM
MH  - Alkaloids/*chemistry/isolation & purification/metabolism
MH  - Animals
MH  - Antiviral Agents/*chemistry/isolation & purification/metabolism
MH  - Circular Dichroism
MH  - HeLa Cells
MH  - Humans
MH  - Molecular Conformation
MH  - Myanmar
MH  - Porifera/*chemistry/metabolism
MH  - vpr Gene Products, Human Immunodeficiency Virus/antagonists & 
      inhibitors/genetics/metabolism
OTO - NOTNLM
OT  - Stylissa massa
OT  - TREx-HeLa-Viral protein R (Vpr)
OT  - pyrrolactam
OT  - stylissaol A
EDAT- 2021/07/02 06:00
MHDA- 2021/08/20 06:00
CRDT- 2021/07/01 06:16
PHST- 2021/07/01 06:16 [entrez]
PHST- 2021/07/02 06:00 [pubmed]
PHST- 2021/08/20 06:00 [medline]
AID - 10.1248/cpb.c21-00227 [doi]
PST - ppublish
SO  - Chem Pharm Bull (Tokyo). 2021;69(7):702-705. doi: 10.1248/cpb.c21-00227.