PMID- 34194812
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 2051-3380 (Print)
IS  - 2051-3380 (Electronic)
IS  - 2051-3380 (Linking)
VI  - 9
IP  - 8
DP  - 2021 Aug
TI  - Assessment of the rapid effect of dupilumab in two cases of severe asthma 
      comorbid with recurrent eosinophilic chronic rhinosinusitis after endoscopic 
      sinus surgery.
PG  - e00804
LID - 10.1002/rcr2.804 [doi]
LID - e00804
AB  - Dupilumab, a human monoclonal antibody against interleukin-4 (IL-4) and IL-13, 
      has been approved for treating severe asthma and eosinophilic chronic 
      rhinosinusitis (ECRS). Patients with ECRS are often candidates for endoscopic 
      sinus surgery (ESS). However, a considerable number of patients have recurrent 
      ECRS. ECRS is an important factor influencing asthma control. Here, we present 
      two cases of severe asthma and recurrent ECRS after ESS. Although they had been 
      treated with inhaled corticosteroids and a long-acting beta2-agonist, they 
      experienced frequent asthma exacerbations. Laboratory examinations revealed 
      increased serum eosinophils and immunoglobulin E (IgE). Furthermore, the Asthma 
      Control Test (ACT) score and forced expiratory volume in 1 sec (FEV(1)) were 
      indicative of airway obstruction. After treatment with dupilumab, asthma, 
      rhinosinusitis symptoms, and pulmonary function improved remarkably. Dupilumab 
      therapy improved quality of life in these patients with severe asthma and ECRS.
CI  - (c) 2021 The Authors. Respirology Case Reports published by John Wiley & Sons 
      Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
FAU - Kai, Yoshiro
AU  - Kai Y
AUID- ORCID: 0000-0001-6197-5176
AD  - Department of Respiratory Medicine Minami-Nara General Medical Center Nara Japan.
AD  - Department of Respiratory Medicine Nara Medical University Nara Japan.
FAU - Yoshikawa, Masanori
AU  - Yoshikawa M
AD  - Department of Respiratory Medicine Nara Medical University Nara Japan.
FAU - Matsuda, Masayuki
AU  - Matsuda M
AD  - Department of Respiratory Medicine Minami-Nara General Medical Center Nara Japan.
FAU - Fukuoka, Atsuhiko
AU  - Fukuoka A
AD  - Department of Internal Medicine Yoshino Hospital Nara Japan.
FAU - Fujita, Yukio
AU  - Fujita Y
AD  - Department of Respiratory Medicine Nara Medical University Nara Japan.
FAU - Yamauchi, Motoo
AU  - Yamauchi M
AD  - Department of Respiratory Medicine Nara Medical University Nara Japan.
FAU - Muro, Shigeo
AU  - Muro S
AUID- ORCID: 0000-0001-7452-9191
AD  - Department of Respiratory Medicine Nara Medical University Nara Japan.
LA  - eng
PT  - Case Reports
DEP - 20210623
PL  - United States
TA  - Respirol Case Rep
JT  - Respirology case reports
JID - 101631052
PMC - PMC8222642
OTO - NOTNLM
OT  - Asthma
OT  - IL-13
OT  - IL-4
OT  - dupilumab
OT  - rhinosinusitis
EDAT- 2021/07/02 06:00
MHDA- 2021/07/02 06:01
PMCR- 2021/06/23
CRDT- 2021/07/01 06:59
PHST- 2020/12/14 00:00 [received]
PHST- 2021/05/22 00:00 [revised]
PHST- 2021/06/03 00:00 [accepted]
PHST- 2021/07/01 06:59 [entrez]
PHST- 2021/07/02 06:00 [pubmed]
PHST- 2021/07/02 06:01 [medline]
PHST- 2021/06/23 00:00 [pmc-release]
AID - RCR2804 [pii]
AID - 10.1002/rcr2.804 [doi]
PST - epublish
SO  - Respirol Case Rep. 2021 Jun 23;9(8):e00804. doi: 10.1002/rcr2.804. eCollection 
      2021 Aug.