PMID- 34194813 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240402 IS - 2051-3380 (Print) IS - 2051-3380 (Electronic) IS - 2051-3380 (Linking) VI - 9 IP - 8 DP - 2021 Aug TI - Allergic bronchopulmonary aspergillosis in a patient with ankylosing spondylitis treated with adalimumab. PG - e00805 LID - 10.1002/rcr2.805 [doi] LID - e00805 AB - We herein report a case of allergic bronchopulmonary aspergillosis (ABPA) that occurred in a man treated with adalimumab for ankylosing spondylitis (AS). A 69-year-old man with a history of ankylosing spondylitis treated by adalimumab, an anti-tumour necrosis factor-alpha (TNF-alpha) antibody, developed cough and wheezing. Chest computed tomography showed obstruction of dilated left upper lobe bronchus by high attenuation mucus as well as central bronchiectasis. Both Aspergillus-specific immunoglobulin E (IgE) and Aspergillus precipitating antibody were positive and Aspergillus fumigatus was detected in a sputum culture. According to the new diagnostic criteria, the patient was diagnosed with ABPA. His condition rapidly improved after the withdrawal of adalimumab and initiation of prednisolone and itraconazole. Anti-TNF-alpha antibody might cause ABPA through both aggravation of the host's T-helper 2 immunological response and anti-fungal response. CI - (c) 2021 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. FAU - Suzuki, Yudai AU - Suzuki Y AD - Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital Tokyo Japan. FAU - Takasaka, Naoki AU - Takasaka N AUID- ORCID: 0000-0002-3016-233X AD - Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital Tokyo Japan. FAU - Matsubayashi, Sachi AU - Matsubayashi S AUID- ORCID: 0000-0002-2291-2137 AD - Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital Tokyo Japan. FAU - Kojima, Ayako AU - Kojima A AD - Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital Tokyo Japan. FAU - Shinfuku, Kyota AU - Shinfuku K AD - Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital Tokyo Japan. FAU - Hasegawa, Tsukasa AU - Hasegawa T AD - Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital Tokyo Japan. FAU - Yamada, Masami AU - Yamada M AD - Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital Tokyo Japan. FAU - Fujisaki, Ikumi AU - Fujisaki I AD - Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital Tokyo Japan. FAU - Seki, Aya AU - Seki A AD - Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital Tokyo Japan. FAU - Seki, Yoshitaka AU - Seki Y AD - Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital Tokyo Japan. FAU - Ishikawa, Takeo AU - Ishikawa T AD - Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital Tokyo Japan. FAU - Kuwano, Kazuyoshi AU - Kuwano K AD - Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Hospital Tokyo Japan. LA - eng PT - Case Reports DEP - 20210623 PL - United States TA - Respirol Case Rep JT - Respirology case reports JID - 101631052 PMC - PMC8222654 OTO - NOTNLM OT - Adalimumab OT - allergic bronchopulmonary aspergillosis OT - ankylosing spondylitis OT - anti-tumour necrosis factor-alpha antibody EDAT- 2021/07/02 06:00 MHDA- 2021/07/02 06:01 PMCR- 2021/06/23 CRDT- 2021/07/01 06:59 PHST- 2021/05/12 00:00 [received] PHST- 2021/06/01 00:00 [revised] PHST- 2021/06/03 00:00 [accepted] PHST- 2021/07/01 06:59 [entrez] PHST- 2021/07/02 06:00 [pubmed] PHST- 2021/07/02 06:01 [medline] PHST- 2021/06/23 00:00 [pmc-release] AID - RCR2805 [pii] AID - 10.1002/rcr2.805 [doi] PST - epublish SO - Respirol Case Rep. 2021 Jun 23;9(8):e00805. doi: 10.1002/rcr2.805. eCollection 2021 Aug.