PMID- 34194961
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210702
IS  - 2211-3355 (Print)
IS  - 2211-3355 (Electronic)
IS  - 2211-3355 (Linking)
VI  - 23
DP  - 2021 Sep
TI  - Alcohol and drug consumption among motor vehicle drivers in the Brittany region 
      of France: A 9-year cross-sectional population study.
PG  - 101454
LID - 10.1016/j.pmedr.2021.101454 [doi]
LID - 101454
AB  - The primary objective of the present study was to evaluate the frequency of 
      positive tests for alcohol and drugs during roadside testing or after road 
      accidents among drivers in the Brittany region of France. The study's secondary 
      objective was to describe the blood concentrations of the substances found during 
      these tests, in order to provide a scientific basis for the establishment or 
      modification of legislative threshold values for road injuries prevention. We 
      performed a cross-sectional study of a database compiled by Rennes University 
      Hospital's toxicology laboratory in the Brittany region of France between 2010 
      and 2018. Driver's age, sex, and test status (positive or negative), and blood 
      levels of ethanol, 9-tetrahydrocannabinol (THC), methylene dioxymethamphetamine 
      (MDMA), amphetamine, benzoylecgonine and 6-monoacetylmorphine (6-MAM) were 
      collected. Twelve thousand four hundred and ninety-seven drivers (males: 86.1%; 
      median (range) age: 29 (15-94)) have provided roadside blood samples, giving a 
      total of 25,998 test results. Among the 10,996 drivers with at least one positive 
      test, the median blood concentrations of ethanol, THC, MDMA, amphetamine, 
      benzoylecgonine, and 6-MAM were respectively 1.82 g/L, 2.41 ng/mL, 138.4 ng/mL, 
      67.7 ng/mL, 173.3 ng/mL, and 0.97 ng/mL. 1159 (10.54%) of the 10,996 drivers 
      tested positive for two or more substances, and 151 (1.4%) tested positive for 
      three or more substances. With the exception of heroin, the currently recommended 
      threshold values appear to be appropriate for road injuries prevention with 
      regard to the concentrations observed in offenders.
CI  - (c) 2021 The Author(s).
FAU - Le Dare, Brendan
AU  - Le Dare B
AD  - Rennes University Hospital, Forensic Toxicology Laboratory, F-35000 Rennes, 
      France.
AD  - Univ. Rennes, INSERM, INRA, CHU Rennes, Institut NuMeCan (Nutrition, Metabolism 
      and Cancer), F-35000 Rennes, France.
FAU - Degremont, Adeline
AU  - Degremont A
AD  - Rennes University Hospital, Pharmacovigilance, Pharmacoepidemiology and Drug 
      Information Centre, Department of Clinical Pharmacology, F-35033 Rennes, France.
AD  - Univ Rennes, EA 7449 REPERES 'Pharmacoepidemiology and Health Services Research', 
      F-35000 Rennes, France.
FAU - Couty, Clemence
AU  - Couty C
AD  - Rennes University Hospital, Forensic Toxicology Laboratory, F-35000 Rennes, 
      France.
FAU - Baert, Alain
AU  - Baert A
AD  - Rennes University Hospital, Department of Forensic Medicine, F-35000 Rennes, 
      France.
FAU - Bouvet, Renaud
AU  - Bouvet R
AD  - Rennes University Hospital, Department of Forensic Medicine, F-35000 Rennes, 
      France.
AD  - Univ. Rennes, EA IDPSP - UR1_RS438, F-35000 Rennes, France.
FAU - Morel, Isabelle
AU  - Morel I
AD  - Rennes University Hospital, Forensic Toxicology Laboratory, F-35000 Rennes, 
      France.
AD  - Univ. Rennes, INSERM, INRA, CHU Rennes, Institut NuMeCan (Nutrition, Metabolism 
      and Cancer), F-35000 Rennes, France.
FAU - Gicquel, Thomas
AU  - Gicquel T
AD  - Rennes University Hospital, Forensic Toxicology Laboratory, F-35000 Rennes, 
      France.
AD  - Univ. Rennes, INSERM, INRA, CHU Rennes, Institut NuMeCan (Nutrition, Metabolism 
      and Cancer), F-35000 Rennes, France.
LA  - eng
PT  - Journal Article
DEP - 20210617
PL  - United States
TA  - Prev Med Rep
JT  - Preventive medicine reports
JID - 101643766
PMC - PMC8227838
OTO - NOTNLM
OT  - Cross sectional study
OT  - Descriptive epidemiology
OT  - Motor vehicle
OT  - Policy
OT  - Prevention
OT  - Public health
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2021/07/02 06:00
MHDA- 2021/07/02 06:01
PMCR- 2021/06/17
CRDT- 2021/07/01 07:01
PHST- 2020/11/05 00:00 [received]
PHST- 2021/04/19 00:00 [revised]
PHST- 2021/04/25 00:00 [accepted]
PHST- 2021/07/01 07:01 [entrez]
PHST- 2021/07/02 06:00 [pubmed]
PHST- 2021/07/02 06:01 [medline]
PHST- 2021/06/17 00:00 [pmc-release]
AID - S2211-3355(21)00144-3 [pii]
AID - 101454 [pii]
AID - 10.1016/j.pmedr.2021.101454 [doi]
PST - epublish
SO  - Prev Med Rep. 2021 Jun 17;23:101454. doi: 10.1016/j.pmedr.2021.101454. 
      eCollection 2021 Sep.