PMID- 34198299
OWN - NLM
STAT- MEDLINE
DCOM- 20220321
LR  - 20220321
IS  - 2235-3186 (Electronic)
IS  - 1660-8151 (Linking)
VI  - 145
IP  - 6
DP  - 2021
TI  - Relationship between Renal Damage and Serum Complement C3 in Children with 
      Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.
PG  - 633-641
LID - 10.1159/000516533 [doi]
AB  - BACKGROUND: Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) 
      disease is a well-known antibody-induced autoimmune disease. The pathogenesis of 
      AAV has not yet been completely clarified, but may be related to heredity, 
      infection, environmental factors, cellular immunity, etc. In recent years, 
      complement in AAV pathogenesis has become the latest research hotspot, and the 
      decrease of serum complement C3 is associated with poor prognosis of 
      anti-neutrophil cytoplasmic antibody-associated glomerulonephritis. In the 
      current study, we investigated the associations between serum complement C3 and 
      kidney injury in AAV children. METHODS: Twenty-four children with AAV admitted to 
      our hospital from June 2014 to June 2019 were divided into the low C3 group and 
      the normal C3 group. All the children have undergone renal biopsy. The clinical 
      manifestations, laboratory tests, renal pathology, treatment, and prognosis of 
      the 2 groups were observed. The primary end point was end-stage renal disease 
      (ESRD). RESULTS: It was shown that kidney injury was more obvious in patients 
      with low C3 than in patients with normal C3 serum. The values of ESR, Scr, and UA 
      before treatment in the low C3 group were higher than those in the normal C3 
      group (p < 0.01); the values of RBC, Hb, PLT, ALB, LDH, and eGFR in the normal C3 
      group were higher than those in the low C3 group (p < 0.01). The values of 
      urinary protein and NAG enzyme in the low C3 group were higher than those in the 
      normal C3 group (p < 0.01). The area of glomerular abandonment, sclerosis, 
      segmental sclerosis, crescent, cellular crescent, cellular fibrous crescent, 
      fibrous crescent, segmental loop necrosis, and the number of cases with acute 
      renal tubulointerstitial lesions in the low C3 group were bigger than those in 
      the normal C3 group (p < 0.05 and < 0.01). The number of cases with C3 deposition 
      in the low C3 group was higher than that in the normal C3 group (p < 0.05). The 
      number of patients receiving CRRT and PE in the low C3 group was higher than that 
      in the normal C3 group (p < 0.05 and < 0.01). In this study, 3 children entered 
      the stage of ESRD and 1 died in the low C3 group. CONCLUSION: The kidney injury 
      of AAV children with low complement C3 is serious, and the prognosis is poor. We 
      should pay attention to the influence of decreased complement C3 on the condition 
      and prognosis of AAV children.
CI  - (c) 2021 S. Karger AG, Basel.
FAU - Zhang, Pei
AU  - Zhang P
AD  - Paediatrics of Jinling Hospital, Nanjing, China, zhang.pei.2008@hotmail.com.
FAU - Yang, Xiao
AU  - Yang X
AD  - Paediatrics of Jinling Hospital, Nanjing, China.
FAU - He, Xu
AU  - He X
AD  - Paediatrics of Jinling Hospital, Nanjing, China.
FAU - Hu, Jian
AU  - Hu J
AD  - Department of Paediatrics, Jinling Hospital, The First School of Clinical 
      Medicine, Southern Medical University, Guangzhou, China.
FAU - Gao, Chun-Lin
AU  - Gao CL
AD  - Paediatrics of Jinling Hospital, Nanjing, China.
FAU - Xia, Zheng-Kun
AU  - Xia ZK
AD  - Paediatrics of Jinling Hospital, Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20210701
PL  - Switzerland
TA  - Nephron
JT  - Nephron
JID - 0331777
RN  - 0 (Complement C3)
SB  - IM
MH  - Adolescent
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/blood/*complications
MH  - Child
MH  - Complement C3/*metabolism
MH  - Female
MH  - Glomerulonephritis/*etiology
MH  - Humans
MH  - Male
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Anti-neutrophil cytoplasmic antibody-associated vasculitis
OT  - Children
OT  - Complement C3
OT  - Kidney injury
EDAT- 2021/07/02 06:00
MHDA- 2022/03/22 06:00
CRDT- 2021/07/01 20:30
PHST- 2020/04/01 00:00 [received]
PHST- 2021/03/21 00:00 [accepted]
PHST- 2021/07/02 06:00 [pubmed]
PHST- 2022/03/22 06:00 [medline]
PHST- 2021/07/01 20:30 [entrez]
AID - 000516533 [pii]
AID - 10.1159/000516533 [doi]
PST - ppublish
SO  - Nephron. 2021;145(6):633-641. doi: 10.1159/000516533. Epub 2021 Jul 1.