PMID- 34198684
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210705
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 12
DP  - 2021 Jun 14
TI  - Sex Hormones Related Ocular Dryness in Breast Cancer Women.
LID - 10.3390/jcm10122620 [doi]
LID - 2620
AB  - BACKGROUND: Dry eye syndrome (DES) is strictly connected to systemic and topical 
      sex hormones. Breast cancer treatment, the subsequent hormonal therapy, the 
      subsequent hyperandrogenism and the early sudden menopause, may be responsible 
      for ocular surface system failure and its clinical manifestation as dry eye 
      disease. This local dryness is part of the breast cancer iatrogenic dryness, 
      which affects overall mucosal tissue in the fragile population of those with 
      breast cancer. METHODS: A literature review regarding the role of sex hormone 
      changes and systemic hormonal replacement treatments (SHRT) in DES available on 
      PubMed and Web of Science was made without any restriction of language. RESULTS: 
      Androgens exert their role on the ocular surface supporting meibomian gland 
      function and exerting a pro-sebaceous effect. Estrogen seems to show a 
      pro/inflammatory role on the ocular surface, while SHRT effects on dry eye are 
      still not well defined, determining apparently contradictory consequences on the 
      ocular surface homeostasis. The role of sex hormones on dry eye pathogenesis is 
      most likely the result of a strict crosstalk between the protective androgens 
      effects and the androgen-modulating effects of estrogens on the meibomian glands. 
      CONCLUSIONS: Patients with a pathological or iatrogenic hormonal imbalance, such 
      as in the case of breast cancer, should be assessed for dry eye disease, as well 
      as systemic dryness, in order to restore their social and personal quality of 
      life.
FAU - Grasso, Antonella
AU  - Grasso A
AD  - Breast Unit, University Campus Bio-Medico, 00128 Rome, Italy.
FAU - Di Zazzo, Antonio
AU  - Di Zazzo A
AUID- ORCID: 0000-0002-5264-5973
AD  - Ophthalmology Operative Complex Unit, University Campus Bio-Medico, 00128 Rome, 
      Italy.
FAU - Giannaccare, Giuseppe
AU  - Giannaccare G
AUID- ORCID: 0000-0003-2617-0289
AD  - Department of Ophthalmology, University Magna Graecia of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Sung, Jaemyoung
AU  - Sung J
AUID- ORCID: 0000-0002-9441-3687
AD  - Department of Ophthalmology, School of Medicine, Juntendo University, 1130033 
      Tokyo, Japan.
FAU - Inomata, Takenori
AU  - Inomata T
AUID- ORCID: 0000-0003-3435-1055
AD  - Department of Ophthalmology, School of Medicine, Juntendo University, 1130033 
      Tokyo, Japan.
FAU - Shih, Kendrick Co
AU  - Shih KC
AUID- ORCID: 0000-0001-6255-2941
AD  - Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of 
      Hong Kong, Hong Kong.
FAU - Micera, Alessandra
AU  - Micera A
AD  - Research and Development Laboratory for Biochemical, Molecular and Cellular 
      Applications in Ophthalmological Sciences, IRCCS-Fondazione Bietti, 00198 Rome, 
      Italy.
FAU - Gaudenzi, Daniele
AU  - Gaudenzi D
AD  - Ophthalmology Operative Complex Unit, University Campus Bio-Medico, 00128 Rome, 
      Italy.
FAU - Spelta, Sara
AU  - Spelta S
AUID- ORCID: 0000-0002-9442-5741
AD  - Ophthalmology Operative Complex Unit, University Campus Bio-Medico, 00128 Rome, 
      Italy.
FAU - Romeo, Maria Angela
AU  - Romeo MA
AD  - School of Medicine, Humanitas University, 20089 Milan, Italy.
FAU - Orsaria, Paolo
AU  - Orsaria P
AD  - Breast Unit, University Campus Bio-Medico, 00128 Rome, Italy.
FAU - Coassin, Marco
AU  - Coassin M
AUID- ORCID: 0000-0003-3404-0425
AD  - Ophthalmology Operative Complex Unit, University Campus Bio-Medico, 00128 Rome, 
      Italy.
FAU - Altomare, Vittorio
AU  - Altomare V
AD  - Breast Unit, University Campus Bio-Medico, 00128 Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210614
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8232194
OTO - NOTNLM
OT  - breast cancer
OT  - dry eye syndrome
OT  - ocular surface equilibrium
OT  - sex hormones
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/03 06:00
MHDA- 2021/07/03 06:01
PMCR- 2021/06/14
CRDT- 2021/07/02 01:01
PHST- 2021/05/11 00:00 [received]
PHST- 2021/06/09 00:00 [revised]
PHST- 2021/06/10 00:00 [accepted]
PHST- 2021/07/02 01:01 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/03 06:01 [medline]
PHST- 2021/06/14 00:00 [pmc-release]
AID - jcm10122620 [pii]
AID - jcm-10-02620 [pii]
AID - 10.3390/jcm10122620 [doi]
PST - epublish
SO  - J Clin Med. 2021 Jun 14;10(12):2620. doi: 10.3390/jcm10122620.