PMID- 34199053
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210711
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 13
DP  - 2021 Jun 27
TI  - Systemic Adverse Events and Use of Antipyretics Predict the Neutralizing Antibody 
      Positivity Early after the First Dose of ChAdOx1 Coronavirus Disease Vaccine.
LID - 10.3390/jcm10132844 [doi]
LID - 2844
AB  - Vaccination is considered crucial for the eradication of the coronavirus disease 
      (COVID-19). In our medical center in Korea, most health care workers (HCWs) were 
      vaccinated with the ChAdOx1 COVID-19 vaccine. After vaccination, many HCWs 
      complained of adverse events (AEs). However, it remains unclear whether the 
      production of neutralizing antibodies (NAb) was affected. Therefore, here, we 
      aimed to evaluate AEs and early NAb production in relatively healthy Asians who 
      received the ChAdOx1 vaccine and determine the effect of AEs and antipyretics on 
      early NAb production against COVID-19. Of the 182 Korean HCWs who received the 
      first dose of ChAdOx1 vaccine, 172 (94.5%) experienced >/=1 adverse events and 148 
      (81.3%) tested positive for NAb 33-40 days after the vaccination. NAb-positive 
      vaccine recipients reported systemic AEs and consumed acetaminophen more 
      frequently than NAb-negative recipients. We identified an association between 
      antibody response and COVID-19 vaccine-related AEs. In conclusion, most ChAdOx1 
      vaccine recipients reported AEs in our medical center.
FAU - Park, Ji Young
AU  - Park JY
AUID- ORCID: 0000-0002-6777-0494
AD  - Department of Pediatrics, Chung-Ang University Hospital, Seoul 06973, Korea.
FAU - Choi, Seong-Ho
AU  - Choi SH
AUID- ORCID: 0000-0001-8108-2412
AD  - Department of Internal Medicine, Division of Infectious Diseases, Chung-Ang 
      University Hospital, Seoul 06973, Korea.
FAU - Chung, Jin-Won
AU  - Chung JW
AUID- ORCID: 0000-0003-4811-6056
AD  - Department of Internal Medicine, Division of Infectious Diseases, Chung-Ang 
      University Hospital, Seoul 06973, Korea.
FAU - Hwang, Min-Hyung
AU  - Hwang MH
AD  - Department of Internal Medicine, Division of Infectious Diseases, Chung-Ang 
      University Hospital, Seoul 06973, Korea.
FAU - Kim, Min-Chul
AU  - Kim MC
AD  - Department of Internal Medicine, Division of Infectious Diseases, Chung-Ang 
      University Hospital, Seoul 06973, Korea.
LA  - eng
PT  - Journal Article
DEP - 20210627
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8268750
OTO - NOTNLM
OT  - SARS-CoV-2
OT  - health care workers
OT  - neutralizing antibodies
OT  - vaccination
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/03 06:00
MHDA- 2021/07/03 06:01
PMCR- 2021/06/27
CRDT- 2021/07/02 01:02
PHST- 2021/05/11 00:00 [received]
PHST- 2021/06/19 00:00 [revised]
PHST- 2021/06/24 00:00 [accepted]
PHST- 2021/07/02 01:02 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/03 06:01 [medline]
PHST- 2021/06/27 00:00 [pmc-release]
AID - jcm10132844 [pii]
AID - jcm-10-02844 [pii]
AID - 10.3390/jcm10132844 [doi]
PST - epublish
SO  - J Clin Med. 2021 Jun 27;10(13):2844. doi: 10.3390/jcm10132844.