PMID- 34200792
OWN - NLM
STAT- MEDLINE
DCOM- 20210726
LR  - 20211118
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 12
DP  - 2021 Jun 10
TI  - Homocysteine and Age-Related Central Nervous System Diseases: Role of 
      Inflammation.
LID - 10.3390/ijms22126259 [doi]
LID - 6259
AB  - Hyperhomocysteinemia (HHcy) is remarkably common among the aging population. The 
      relation between HHcy and the development of neurodegenerative diseases, such as 
      Alzheimer's disease (AD) and eye diseases, and age-related macular degeneration 
      (AMD) and diabetic retinopathy (DR) in elderly people, has been established. 
      Disruption of the blood barrier function of the brain and retina is one of the 
      most important underlying mechanisms associated with HHcy-induced 
      neurodegenerative and retinal disorders. Impairment of the barrier function 
      triggers inflammatory events that worsen disease pathology. Studies have shown 
      that AD patients also suffer from visual impairments. As an extension of the 
      central nervous system, the retina has been suggested as a prominent site of AD 
      pathology. This review highlights inflammation as a possible underlying mechanism 
      of HHcy-induced barrier dysfunction and neurovascular injury in aging diseases 
      accompanied by HHcy, focusing on AD.
FAU - Tawfik, Amany
AU  - Tawfik A
AUID- ORCID: 0000-0002-0245-8256
AD  - Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, 
      Augusta University, Augusta, GA 30912, USA.
AD  - James and Jean Culver Vision Discovery Institute, MCG, Augusta University, 
      Augusta, GA 30912, USA.
AD  - Department of Cellular Biology and Anatomy, Medical College of Georgia (MCG), 
      Augusta University, Augusta, GA 30912, USA.
AD  - Department of Ophthalmology, MCG, Augusta University, Augusta, GA 30912, USA.
AD  - Eye Research Institue, Oakland University, Rochester, MI 48309, USA.
FAU - Elsherbiny, Nehal M
AU  - Elsherbiny NM
AUID- ORCID: 0000-0001-5167-3377
AD  - Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, 
      Augusta University, Augusta, GA 30912, USA.
AD  - James and Jean Culver Vision Discovery Institute, MCG, Augusta University, 
      Augusta, GA 30912, USA.
AD  - Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 
      35516, Egypt.
FAU - Zaidi, Yusra
AU  - Zaidi Y
AD  - Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, 
      Augusta University, Augusta, GA 30912, USA.
AD  - James and Jean Culver Vision Discovery Institute, MCG, Augusta University, 
      Augusta, GA 30912, USA.
FAU - Rajpurohit, Pragya
AU  - Rajpurohit P
AD  - Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, 
      Augusta University, Augusta, GA 30912, USA.
AD  - James and Jean Culver Vision Discovery Institute, MCG, Augusta University, 
      Augusta, GA 30912, USA.
LA  - eng
GR  - 1R01EY029751-02/NEI grant awards/
GR  - R01 EY029751/EY/NEI NIH HHS/United States
GR  - #16SDG3070001/American Heart Association/
GR  - P30 EY031631/EY/NEI NIH HHS/United States
GR  - P30EY031631/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20210610
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Central Nervous System Diseases/etiology/metabolism/*pathology
MH  - Homocysteine/*metabolism
MH  - Humans
MH  - Hyperhomocysteinemia/etiology/metabolism/*pathology
MH  - Inflammation/*physiopathology
PMC - PMC8230490
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - age-related macular degeneration
OT  - diabetic retinopathy
OT  - hyperhomocysteinemia
OT  - inflammation
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/03 06:00
MHDA- 2021/07/27 06:00
PMCR- 2021/06/10
CRDT- 2021/07/02 01:08
PHST- 2021/04/22 00:00 [received]
PHST- 2021/06/02 00:00 [revised]
PHST- 2021/06/07 00:00 [accepted]
PHST- 2021/07/02 01:08 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/27 06:00 [medline]
PHST- 2021/06/10 00:00 [pmc-release]
AID - ijms22126259 [pii]
AID - ijms-22-06259 [pii]
AID - 10.3390/ijms22126259 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Jun 10;22(12):6259. doi: 10.3390/ijms22126259.