PMID- 34201697
OWN - NLM
STAT- MEDLINE
DCOM- 20210721
LR  - 20240402
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 26
IP  - 13
DP  - 2021 Jun 23
TI  - Recent Developments in Therapeutic and Nutraceutical Applications of 
      p-Methoxycinnamic Acid from Plant Origin.
LID - 10.3390/molecules26133827 [doi]
LID - 3827
AB  - The p-methoxycinnamic acid (p-MCA) is one of the most studied phenylpropanoids 
      with high importance not only in the wide spectrum of therapeutic activities but 
      also its potential application for the food industry. This natural compound 
      derived from plants exhibits a wide range of biologically useful properties; 
      therefore, during the last two decades it has been extensively tested for 
      therapeutic and nutraceutical applications. This article presents the natural 
      sources of p-MCA, its metabolism, pharmacokinetic properties, and safety of its 
      application. The possibilities of using this dietary bioactive compound as a 
      nutraceutical agent that may be used as functional food ingredient playing a 
      vital role in the prevention and treatment of many chronic diseases is also 
      discussed. We present the antidiabetic, anticancer, antimicrobial, hepato-, and 
      neuroprotective activities of p-MCA and methods of its lipophilization that have 
      been developed so far to increase its industrial application and bioavailability 
      in the biological systems.
FAU - Plowuszynska, Anna
AU  - Plowuszynska A
AD  - Department of Chemistry, Wroclaw University of Environmental and Life Sciences, 
      Norwida 25, 50-375 Wroclaw, Poland.
FAU - Gliszczynska, Anna
AU  - Gliszczynska A
AUID- ORCID: 0000-0002-0218-6369
AD  - Department of Chemistry, Wroclaw University of Environmental and Life Sciences, 
      Norwida 25, 50-375 Wroclaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210623
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Cinnamates)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Polyphenols)
RN  - 0 (Propanols)
RN  - 0F897O3O4M (1-phenylpropanol)
RN  - 140-10-3 (cinnamic acid)
SB  - IM
MH  - Anti-Infective Agents/pharmacology/therapeutic use
MH  - Antineoplastic Agents/pharmacology/therapeutic use
MH  - Cinnamates/*chemistry/metabolism/*pharmacology/therapeutic use
MH  - Dietary Supplements
MH  - Hypoglycemic Agents/pharmacology/therapeutic use
MH  - Liver/drug effects/physiology
MH  - Neuroprotective Agents/pharmacology/therapeutic use
MH  - Polyphenols/analysis/pharmacology
MH  - Propanols/analysis/pharmacology
PMC - PMC8270276
OTO - NOTNLM
OT  - biological activity
OT  - methoxylated derivatives of cinnamic acid
OT  - p-methoxycinnamic acid
OT  - phenylpropanoids
OT  - polyphenols
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/03 06:00
MHDA- 2021/07/22 06:00
PMCR- 2021/06/23
CRDT- 2021/07/02 01:11
PHST- 2021/06/09 00:00 [received]
PHST- 2021/06/21 00:00 [revised]
PHST- 2021/06/21 00:00 [accepted]
PHST- 2021/07/02 01:11 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/22 06:00 [medline]
PHST- 2021/06/23 00:00 [pmc-release]
AID - molecules26133827 [pii]
AID - molecules-26-03827 [pii]
AID - 10.3390/molecules26133827 [doi]
PST - epublish
SO  - Molecules. 2021 Jun 23;26(13):3827. doi: 10.3390/molecules26133827.