PMID- 34201804
OWN - NLM
STAT- MEDLINE
DCOM- 20210803
LR  - 20240402
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 18
IP  - 13
DP  - 2021 Jun 23
TI  - The Effects of Interval Training and Continuous Training on Cardiopulmonary 
      Fitness and Exercise Tolerance of Patients with Heart Failure-A Systematic Review 
      and Meta-Analysis.
LID - 10.3390/ijerph18136761 [doi]
LID - 6761
AB  - PURPOSE: To investigate the effects of interval training (IT) as compared with 
      continuous training (CT) on cardiorespiratory fitness and exercise tolerance of 
      patients with heart failure (HF), with the aim to provide reasonable exercise 
      prescriptions for patients with HF. METHODS: Through searching electronic 
      databases, randomized controlled studies were collected. The included studies 
      were evaluated for methodological quality using the Cochrane risk of bias 
      assessment tool, and statistical analyses were carried out using Review Manager 
      5.3 and Stata MP 15.1 software. RESULTS: A total of seventeen randomized 
      controlled trials (i.e., studies) with 617 patients were included. The 
      meta-analysis showed that IT can improve a patient's peak oxygen uptake (VO2peak) 
      (MD = 2.08, 95% CI 1.16 to 2.99, p < 0.00001), left ventricular ejection fraction 
      (LVEF) (MD =1.32, 95% CI 0.60 to 2.03, p = 0.0003), and 6-minute walk distance 
      (6MWD) (MD = 25.67, 95% CI 12.87 to 38.47, p < 0.0001) as compared with CT. 
      However, for respiratory exchange ratio (RER) (MD = 0.00, 95% CI -0.02 to 0.03, p 
      = 0.81), CO(2) ventilation equivalent slope (VE/VCO2 slope) (SMD = 0.04, 95% CI 
      -0.23 to 0.31, p = 0.75), and resting heart rate (HRrest) (MD = 0.15, 95% CI 
      -3.00 to 3.29, p = 0.93) there were no statistical significance. CONCLUSIONS: The 
      evidence shows that IT is better than CT for improving the cardiorespiratory 
      fitness and exercise tolerance of patients with HF. Moreover, an intensity of 
      60-80% peak heart rate of IT is the optimal choice for patients. It is hoped 
      that, in the future, more well-designed studies would further expand the 
      meta-analysis results.
FAU - Li, Daxin
AU  - Li D
AUID- ORCID: 0000-0002-6054-3627
AD  - Department of Physical Education, Ocean University of China-Laoshan Campus, 
      Qingdao 266100, China.
FAU - Chen, Ping
AU  - Chen P
AD  - Department of Physical Education, Ocean University of China-Laoshan Campus, 
      Qingdao 266100, China.
FAU - Zhu, Junying
AU  - Zhu J
AD  - Department of Physical Education, Ocean University of China-Laoshan Campus, 
      Qingdao 266100, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20210623
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Exercise
MH  - Exercise Therapy
MH  - *Exercise Tolerance
MH  - *Heart Failure/therapy
MH  - Humans
MH  - Stroke Volume
MH  - Ventricular Function, Left
PMC - PMC8268940
OTO - NOTNLM
OT  - continuous training
OT  - heart failure
OT  - interval training
OT  - meta-analysis
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/03 06:00
MHDA- 2021/08/04 06:00
PMCR- 2021/06/23
CRDT- 2021/07/02 01:12
PHST- 2021/05/19 00:00 [received]
PHST- 2021/06/19 00:00 [revised]
PHST- 2021/06/21 00:00 [accepted]
PHST- 2021/07/02 01:12 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/08/04 06:00 [medline]
PHST- 2021/06/23 00:00 [pmc-release]
AID - ijerph18136761 [pii]
AID - ijerph-18-06761 [pii]
AID - 10.3390/ijerph18136761 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2021 Jun 23;18(13):6761. doi: 
      10.3390/ijerph18136761.