PMID- 34201866
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 13
DP  - 2021 Jun 23
TI  - The Prevalence of Advanced Interatrial Block and Its Relationship to Left Atrial 
      Function in Patients with Transthyretin Cardiac Amyloidosis.
LID - 10.3390/jcm10132764 [doi]
LID - 2764
AB  - BACKGROUND: Advanced interatrial block (aIAB), which is associated with incident 
      atrial fibrillation and stroke, occurs in the setting of blocked interatrial 
      conduction. Atrial amyloid deposition could be a possible substrate for reduced 
      interatrial conduction, but the prevalence of aIAB in patients with transthyretin 
      cardiac amyloidosis (ATTR-CA) is unknown. We aimed to describe the prevalence of 
      aIAB and its relationship to left atrial function in patients with ATTR-CA in 
      comparison to patients with HF and left ventricular hypertrophy but no CA. 
      METHODS: The presence of aIAB was investigated among 75 patients (49 patients 
      with ATTR-CA and 26 with HF but no CA). A comprehensive echocardiographic 
      investigation was performed in all patients, including left atrial strain and 
      strain rate measurements. RESULTS: Among patients with ATTR-CA, 27% had aIAB and 
      in patients with HF but no CA, this figure was 21%, (p = 0.78). The presence of 
      aIAB was associated with a low strain rate during atrial contraction (<0.91 
      s(-1)) (OR: 5.2 (1.4-19.9)), even after adjusting for age and LAVi (OR: 4.5 
      (1.0-19.19)). CONCLUSIONS: Advanced interatrial block is common among patients 
      with ATTR-CA, as well as in patients with heart failure and left ventricular 
      hypertrophy but no CA. aIAB is associated with reduced left atrial contractile 
      function.
FAU - Lindow, Thomas
AU  - Lindow T
AUID- ORCID: 0000-0002-2943-0034
AD  - Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, NSW 
      2065, Australia.
AD  - Department of Clinical Physiology, Research and Development, Vaxjo Central 
      Hospital, Region Kronoberg, 351 88 Vaxjo, Sweden.
AD  - Clinical Physiology, Clinical Sciences, Lund University, 221 00 Lund, Sweden.
FAU - Lindqvist, Per
AU  - Lindqvist P
AUID- ORCID: 0000-0002-8192-9166
AD  - Department of Clinical Physiology, Surgical and Perioperative Sciences, Umea 
      University, 901 87 Umea, Sweden.
LA  - eng
GR  - 20160787,20200160/The Swedish Heart and Lung foundation/
GR  - 2019-01338/The Swedish Research Council/
PT  - Journal Article
DEP - 20210623
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8267751
OTO - NOTNLM
OT  - cardiac amyloidosis
OT  - interatrial block
OT  - left atrial strain
OT  - transthyretin amyloid
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/03 06:00
MHDA- 2021/07/03 06:01
PMCR- 2021/06/23
CRDT- 2021/07/02 01:12
PHST- 2021/05/17 00:00 [received]
PHST- 2021/06/20 00:00 [revised]
PHST- 2021/06/22 00:00 [accepted]
PHST- 2021/07/02 01:12 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/03 06:01 [medline]
PHST- 2021/06/23 00:00 [pmc-release]
AID - jcm10132764 [pii]
AID - jcm-10-02764 [pii]
AID - 10.3390/jcm10132764 [doi]
PST - epublish
SO  - J Clin Med. 2021 Jun 23;10(13):2764. doi: 10.3390/jcm10132764.