PMID- 34202643
OWN - NLM
STAT- MEDLINE
DCOM- 20210713
LR  - 20240410
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 26
IP  - 13
DP  - 2021 Jun 24
TI  - Identification of the Trace Components in BopuzongJian and Macleaya cordata 
      Extract Using LC-MS Combined with a Screening Method.
LID - 10.3390/molecules26133851 [doi]
LID - 3851
AB  - Bopu powder((R)) and Sangrovit((R)) were developed from Macleayacordata and are 
      widely used in agriculture and animal husbandry, but their impurities have been 
      rarely reported in the literature. Impurity analysis is of great importance to 
      the quality and safety of veterinary drugs. In this study, high-performance 
      liquid chromatography/quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS) 
      combined with a screening method was used to screen and characterize the 
      impurities in Bopu powder((R)) and Sangrovit((R)). A total of 58 impurities were 
      screened from Bopu powder((R)) and Sangrovit((R)) using the screening strategies, of 
      which 39 were identified by their accurate m/z value, characteristic MS/MS data, 
      and fragmentation pathways of references. This established method was used for 
      impurity analysis for the first time and proved to be a useful and rapid tool to 
      screen and identify the impurities of Bopu powder((R)) and Sangrovit((R)), especially 
      for those at trace levels in a complex sample. In addition, this study marks the 
      first comprehensive research into impurities in these two products and has great 
      significance for the systematic detection of impurities in other plant-derived 
      drugs.
FAU - Dong, Zhuang
AU  - Dong Z
AD  - Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan 
      Agricultural University, Changsha 410128, China.
AD  - College of Horticulture, Hunan Agricultural University, Changsha 410128, China.
FAU - Liu, Mengting
AU  - Liu M
AD  - Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan 
      Agricultural University, Changsha 410128, China.
AD  - College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, 
      China.
FAU - Zhong, Xiaohong
AU  - Zhong X
AD  - College of Horticulture, Hunan Agricultural University, Changsha 410128, China.
FAU - Ou, Xiaoyong
AU  - Ou X
AD  - Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan 
      Agricultural University, Changsha 410128, China.
AD  - College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, 
      China.
FAU - Yun, Xuan
AU  - Yun X
AD  - Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan 
      Agricultural University, Changsha 410128, China.
AD  - College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, 
      China.
FAU - Wang, Mingcan
AU  - Wang M
AD  - Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan 
      Agricultural University, Changsha 410128, China.
FAU - Ren, Shurui
AU  - Ren S
AD  - Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan 
      Agricultural University, Changsha 410128, China.
FAU - Qing, Zhixing
AU  - Qing Z
AD  - Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan 
      Agricultural University, Changsha 410128, China.
AD  - College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, 
      China.
FAU - Zeng, Jianguo
AU  - Zeng J
AD  - Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan 
      Agricultural University, Changsha 410128, China.
AD  - College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20210624
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Powders)
RN  - 0 (sangrovit)
SB  - IM
EIN - Molecules. 2024 Mar 13;29(6):. PMID: 38543051
MH  - Chromatography, High Pressure Liquid
MH  - *Drug Contamination
MH  - Drugs, Chinese Herbal/*analysis
MH  - Powders
MH  - Spectrometry, Mass, Electrospray Ionization
PMC - PMC8270340
OTO - NOTNLM
OT  - Bopu powder(R)
OT  - LC-MS
OT  - Sangrovit(R)
OT  - impurity analysis
OT  - isoquinoline alkaloids
OT  - screening method
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/03 06:00
MHDA- 2021/07/14 06:00
PMCR- 2021/06/24
CRDT- 2021/07/02 01:14
PHST- 2021/05/13 00:00 [received]
PHST- 2021/06/20 00:00 [revised]
PHST- 2021/06/21 00:00 [accepted]
PHST- 2021/07/02 01:14 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/14 06:00 [medline]
PHST- 2021/06/24 00:00 [pmc-release]
AID - molecules26133851 [pii]
AID - molecules-26-03851 [pii]
AID - 10.3390/molecules26133851 [doi]
PST - epublish
SO  - Molecules. 2021 Jun 24;26(13):3851. doi: 10.3390/molecules26133851.