PMID- 34205729
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210714
IS  - 1424-8247 (Print)
IS  - 1424-8247 (Electronic)
IS  - 1424-8247 (Linking)
VI  - 14
IP  - 6
DP  - 2021 Jun 21
TI  - Whole Body Cryotherapy and Hyperbaric Oxygen Treatment: New Biological Treatment 
      of Depression? A Systematic Review.
LID - 10.3390/ph14060595 [doi]
LID - 595
AB  - Treatment with antidepressants is often insufficiently effective, especially in 
      treatment-resistant depression. In such a situation, it is possible to change the 
      drug, add a second antidepressant, or use pharmacological and non-pharmacological 
      methods of augmenting the effect of pharmacotherapy. New methods that may fall 
      into the scope of multi-module depression treatment as an augmentation of 
      depression treatment are whole body cryotherapy (WBC) and hyperbaric oxygen 
      treatment (HBOT). 545 records were selected and analyzed for these two treatments 
      and finally three clinical trials were selected for analysis. The review also 
      includes data on the possibility of using WBC and HBOT in somatic indications and 
      in organic mental syndromes. Despite the small number of studies on the 
      effectiveness of WBC or HBOT in depression, the current data show that both 
      methods may be effective in the treatment of depression. WBC may be effective in 
      the augmentation of antidepressants, and additionally, it is a method in which a 
      quick antidepressant effect is obtained. HBOT may be effective in endogenous 
      depression, just as it is effective in the treatment of somatic depression 
      symptoms. The results are very preliminary, but if confirmed in subsequent 
      studies, both WBC and HBOT may become new treatment options in treating 
      depression. The authors point to the need and directions for further research 
      into these treatment methods as an augmentation strategy for pharmacological 
      treatment of depression.
FAU - Krzystanek, Marek
AU  - Krzystanek M
AD  - Clinic of Psychiatric Rehabilitation, Department of Psychiatry and Psychotherapy, 
      Faculty of Medical Sciences, Medical University of Silesia in Katowice, Ziolowa 
      45/47, 40-635 Katowice, Poland.
FAU - Romanczyk, Monika
AU  - Romanczyk M
AD  - Clinic of Psychiatric Rehabilitation, Department of Psychiatry and Psychotherapy, 
      Faculty of Medical Sciences, Medical University of Silesia in Katowice, Ziolowa 
      45/47, 40-635 Katowice, Poland.
FAU - Surma, Stanislaw
AU  - Surma S
AD  - Clinic of Psychiatric Rehabilitation, Department of Psychiatry and Psychotherapy, 
      Faculty of Medical Sciences, Medical University of Silesia in Katowice, Ziolowa 
      45/47, 40-635 Katowice, Poland.
FAU - Kozmin-Burzynska, Agnieszka
AU  - Kozmin-Burzynska A
AD  - Clinic of Psychiatric Rehabilitation, Leszek Giec Upper-Silesian Medical Centre 
      of the Medical University of Silesia in Katowice, Ziolowa 45/47, 40-635 Katowice, 
      Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210621
PL  - Switzerland
TA  - Pharmaceuticals (Basel)
JT  - Pharmaceuticals (Basel, Switzerland)
JID - 101238453
PMC - PMC8235744
OTO - NOTNLM
OT  - HBOT
OT  - WBC
OT  - augmentation
OT  - depression
OT  - hyperbaric oxygen treatment
OT  - pharmacotherapy
OT  - treatment resistant depression
OT  - whole body cryotherapy
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/03 06:00
MHDA- 2021/07/03 06:01
PMCR- 2021/06/21
CRDT- 2021/07/02 01:25
PHST- 2021/05/31 00:00 [received]
PHST- 2021/06/18 00:00 [revised]
PHST- 2021/06/19 00:00 [accepted]
PHST- 2021/07/02 01:25 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/03 06:01 [medline]
PHST- 2021/06/21 00:00 [pmc-release]
AID - ph14060595 [pii]
AID - pharmaceuticals-14-00595 [pii]
AID - 10.3390/ph14060595 [doi]
PST - epublish
SO  - Pharmaceuticals (Basel). 2021 Jun 21;14(6):595. doi: 10.3390/ph14060595.