PMID- 34207228
OWN - NLM
STAT- MEDLINE
DCOM- 20210721
LR  - 20210724
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 18
IP  - 12
DP  - 2021 Jun 18
TI  - Auditory and Language Development Assessment of Newborns Aged One to Four Years 
      Exposed to Gestational Zika Virus Infection: A Case Series.
LID - 10.3390/ijerph18126562 [doi]
LID - 6562
AB  - The known neurotropism of the Zika virus (ZikV) suggests that auditory organs and 
      their neural pathways may be affected by prenatal Zika infections. Among the 
      possible manifestations are audiological and language disorders, but so far, the 
      data in the literature are inconclusive. OBJECTIVE: To describe early and late 
      hearing disorders in children with Congenital Zika Virus Infection (CZVI) and 
      evaluate the language development of this population between 14 and 47 months of 
      age and its possible correlation with the alterations found in auditory exams. 
      METHODS: Longitudinal, prospective, observational study of newborns born in Juiz 
      de Fora and its macroregion with confirmed diagnosis of ZikV infection during 
      pregnancy. Participants were examined from one to four years of age for hearing 
      using the transient otoacoustic emissions (TOAE) test, immittance testing and 
      brainstem auditory evoked potential (BAEP), and language using the Bayley Scales 
      of Infant Development-Third Edition (Bayley III). RESULTS: 15 participants were 
      included; eight (53.33%) presented alterations in at least one of the hearing 
      tests, one had an early loss (6%) of sensorineural origin, and seven (46.67%) had 
      a poor language performance. In the three (20%) participants whose audiological 
      exams were altered, there was language impairment, and two (13.33%) participants 
      had extensive malformations in the central nervous system (CNS), presented 
      language delay, and hearing exams were within normality. CONCLUSION: Infants and 
      preschoolers with CZVI may present early neurosensory loss and late hearing loss 
      with fluctuating character. Even if there were no significant association between 
      the audiological exams results and the Bayley III performance, in the present 
      sample, language development was below expectations for the age in the 
      participants who had alterations in the three audiological exams, when there is 
      early hearing loss or extensive lesions to the CNS. The results reinforce the 
      importance of audiological examinations, especially the BAEP morphological and 
      auditory threshold, in monitoring cases of CZVI until at least three years of 
      age.
FAU - Gonik, Liora
AU  - Gonik L
AUID- ORCID: 0000-0001-6945-3954
AD  - Graduate Program of Rehabilitation Sciences and Physical and Functional 
      Performance, Faculty of Physiotherapy, Universidade Federal de Juiz de Fora, Juiz 
      de Fora 36038-330, MG, Brazil.
FAU - Oliveira, Amanda Tupinamba da Fonseca
AU  - Oliveira ATDF
AD  - Graduate Program of Rehabilitation Sciences and Physical and Functional 
      Performance, Faculty of Physiotherapy, Universidade Federal de Juiz de Fora, Juiz 
      de Fora 36038-330, MG, Brazil.
FAU - Chagas, Paula Silva de Carvalho
AU  - Chagas PSC
AUID- ORCID: 0000-0002-4312-0403
AD  - Graduate Program of Rehabilitation Sciences and Physical and Functional 
      Performance, Faculty of Physiotherapy, Universidade Federal de Juiz de Fora, Juiz 
      de Fora 36038-330, MG, Brazil.
FAU - Fronio, Jaqueline da Silva
AU  - Fronio JDS
AUID- ORCID: 0000-0002-6936-8431
AD  - Graduate Program of Rehabilitation Sciences and Physical and Functional 
      Performance, Faculty of Physiotherapy, Universidade Federal de Juiz de Fora, Juiz 
      de Fora 36038-330, MG, Brazil.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20210618
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Child
MH  - Female
MH  - Hearing Tests
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Language Development
MH  - Pregnancy
MH  - Prospective Studies
MH  - *Zika Virus
MH  - *Zika Virus Infection/diagnosis
PMC - PMC8296432
OTO - NOTNLM
OT  - Zika virus
OT  - child development
OT  - children's language
OT  - hearing
OT  - hearing loss
COIS- The authors declare no conflict of interest.
EDAT- 2021/07/03 06:00
MHDA- 2021/07/22 06:00
PMCR- 2021/06/18
CRDT- 2021/07/02 01:30
PHST- 2021/03/30 00:00 [received]
PHST- 2021/06/07 00:00 [revised]
PHST- 2021/06/09 00:00 [accepted]
PHST- 2021/07/02 01:30 [entrez]
PHST- 2021/07/03 06:00 [pubmed]
PHST- 2021/07/22 06:00 [medline]
PHST- 2021/06/18 00:00 [pmc-release]
AID - ijerph18126562 [pii]
AID - ijerph-18-06562 [pii]
AID - 10.3390/ijerph18126562 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2021 Jun 18;18(12):6562. doi: 
      10.3390/ijerph18126562.